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Product Name: Voriconazole
Chemical Name: (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
SYNONYMS: VFEND
CAS Number: 137234-62-9
Manufacturing Company: Pfizer Inc.
Intended Use: Antifungal medication for humans
Emergency Contact: Refer to local Poison Control Center or Emergency Numbers
Hazard Classification: Not classified as hazardous under GHS; can irritate eyes, skin, or respiratory tract upon contact
Label Elements: No pictograms needed; caution statement for potential irritation
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Effects: Dizziness, nausea, mild irritation to eyes and skin
Chronic Effects: Prolonged or repeated exposure might cause allergic reactions or increased sensitivity
Carcinogenicity: Not identified as carcinogenic under OSHA or IARC
Reproductive Effects: No clear evidence from current studies, but consultation with a physician is advised
Voriconazole: 98-100% active ingredient by weight
Other Ingredients: Trace solvents or manufacturing byproducts (not considered hazardous under normal use)
Impurities: Less than 2%, not deemed significant toxicologically
Form: Powder for oral or intravenous use
Inhalation: Move to fresh air, monitor for respiratory distress, seek medical attention if symptoms persist
Skin Contact: Wash off immediately with soap and plenty of water, remove contaminated clothing
Eye Contact: Rinse with copious amounts of water for at least 15 minutes, keep eyelids open, seek medical advice
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical assistance
Most Important Symptoms: Irritation, headache, nausea, possible allergic reactions
Suitable Extinguishing Media: Dry chemical, CO2, foam or water spray
Unsuitable Extinguishing Media: High-pressure water streams may spread powder
Specific Hazards: May produce toxic gases like carbon oxides, nitrogen oxides, and hydrogen fluoride on combustion
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective gear
Special Procedures: Avoid runoff from fire control entering soil or waterways
Personal Precautions: Wear gloves, lab coat, eye protection, and a dust mask or respirator
Environmental Precautions: Prevent entry into drains or watercourses
Cleanup Methods: Sweep up without generating dust; collect in sealed, labeled containers for disposal
Spill Response: Ventilate area, wash spill site after material pickup is complete
Handling: Work in well-ventilated areas, avoid contact with skin, eyes, clothing, prevent inhalation of dust
Safe Storage Conditions: Store in tightly closed container, at 20–25°C, away from light, heat, and incompatible materials
Incompatibilities: Strong oxidizers, acids, and bases
Hygiene Practices: Wash hands thoroughly after handling, do not eat or drink in work area
Special Storage Requirements: Protect from moisture and avoid excessive temperature fluctuations
Exposure Limits: None established for voriconazole; minimize exposure by good laboratory practice
Engineering Controls: Use laboratory fume hoods, local exhaust, or adequate ventilation
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), safety goggles, lab coat, respiratory protection if airborne powder is present
Environmental Controls: Employ spill control measures and secondary containment
Appearance: White to slightly yellow crystalline powder
Molecular Weight: 349.3 g/mol
Odor: Odorless
pH: 6.0–7.0 (for solution form)
Melting Point: 120–130°C
Solubility: Freely soluble in methanol, ethanol, slightly soluble in water
Boiling Point: Data not available
Vapor Pressure: Negligible at room temperature
Partition Coefficient (Log P): 1.80 at 20°C
Chemical Stability: Stable under normal conditions and recommended storage
Hazardous Reactions: No dangerous reactions out of normal handling
Conditions to Avoid: High temperatures, direct sunlight, moisture, incompatible substances
Incompatible Materials: Strong oxidizing agents, acids, and alkalis
Decomposition Products: Produces irritating and toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides upon burning or decomposition
Acute Toxicity: Oral LD₅₀ in rats above 2,000 mg/kg; low toxicity expected on normal exposure
Skin Corrosion/Irritation: Mild irritant in animals
Serious Eye Damage/Irritation: May cause mild, transient irritation
Respiratory Sensitization: Not reported
Skin Sensitization: Possible in allergic individuals
Mutagenicity: Negative in Ames test, not genotoxic in standard systems
Reproductive Toxicity: No significant effects in animal studies at therapeutic doses
Carcinogenicity: No evidence of carcinogenicity from animal studies limited to therapeutic use
Ecotoxicity: Data suggest moderate toxicity to aquatic organisms; avoid uncontrolled environmental release
Persistence and Degradability: Not readily biodegradable; may persist in environment
Bioaccumulative Potential: Not likely to bioaccumulate under normal exposure
Mobility in Soil: Low solubility in water may limit mobility; chemical can adsorb to soils
Other Adverse Effects: Runoff from manufacturing or usage areas should be prevented to protect aquatic life
Waste Treatment Methods: Dispose in accordance with local, regional, national, and international regulations for pharmaceuticals
Unused Product Disposal: Incinerate in approved facility or landfill if permitted
Contaminated Packaging: Triple-rinse containers; dispose as hazardous chemical waste
Special Precautions for Incineration: Do not release to environment, avoid burning in open containers
UN Number: Not regulated for transport
Proper Shipping Name: Voriconazole Preparation
Transport Hazard Class: Not considered hazardous for DOT, IATA, IMDG
Packing Group: None assigned
Environmental Hazards: Not a marine pollutant
Special Transport Precautions: Prevent spillage during loading and unloading; store upright in original container
US Federal Regulations: Not subject to TSCA; not listed on CERCLA, SARA Title III lists
OSHA Status: Not classified as hazardous under OSHA rules
WHMIS Classification (Canada): D2B—Toxic material causing other toxic effects
EU Regulations: Not classified as a dangerous substance under CLP Regulation; exempt as medicinal product
Country-specific Regulations: Subject to pharmaceutical regulations for handling, distribution, and disposal
Other Regulatory Listings: Not listed as controlled substance; handled with general workplace controls for pharmaceuticals
