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Chemical Name: Voglibose
Synonyms: N-(1,3-Dihydroxypropan-2-yl)-valiolamine
CAS Number: 83480-29-9
Recommended Use: Pharmaceutical intermediate, antidiabetic agent
Manufacturer: Major pharmaceutical manufacturing companies worldwide
Emergency Contact: Local health and poison control center, regional emergency medical services
Hazard Classification: Not classified as hazardous according to GHS
Main Health Hazards: May cause irritation of eyes, skin, and respiratory tract
Environmental Hazards: Low risk to aquatic environments at low concentrations, potential risk on large uncontrolled release
Pictograms: No pictograms required for this product
Signal Word: Not applicable
Precautionary Statements: Avoid inhaling dust, prevent contact with skin or eyes, wear suitable protective clothing, follow good laboratory and industrial hygiene practices
Chemical Formula: C10H21NO7
Purity: Typically above 99% for pharmaceutical use
Impurities: ≤1%, may include synthesis byproducts
Physical Form: Off-white to pale yellow crystalline powder
Other Components: No significant hazardous additives or stabilizers
Eye Contact: Rinse cautiously with plenty of water for at least 10 minutes; seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing, wash skin with soap and water; if irritation develops, consult a physician
Inhalation: Move person into fresh air; provide oxygen if necessary; seek medical attention if symptoms such as coughing or shortness of breath occur
Ingestion: Rinse mouth with water, do not induce vomiting, drink plenty of water if conscious; seek immediate medical advice
Most Important Symptoms: Irritation of mucous membranes, mild allergic reactions in sensitive individuals, rarely gastrointestinal discomfort
Suitable Extinguishing Media: Water spray, dry chemical powder, foam, carbon dioxide
Unsuitable Extinguishing Media: Do not use a direct water jet
Specific Hazards: May produce toxic gases such as nitrogen oxides and carbon oxides during combustion
Protective Equipment: Firefighters require full protective gear, self-contained breathing apparatus
Special Procedures: Move undamaged containers from fire area if possible; cool containers with water to prevent pressure build-up
Personal Precautions: Wear dust mask, chemical-resistant gloves, and safety goggles
Environmental Precautions: Prevent runoff into drains, surface waters, and soil; inform authorities in event of large spill
Clean-Up Methods: Sweep or vacuum up spillage without generating dust; transfer to a labeled, closed container
Decontamination Procedures: Clean area with mild detergent and water; ventilate area after cleanup
Safe Handling: Use in well-ventilated areas; avoid generating or breathing dust; wash thoroughly after handling
Storage Conditions: Store in a cool, dry, well-ventilated space; keep container tightly sealed away from incompatible substances
Incompatible Materials: Avoid strong oxidizing agents; keep away from direct sunlight and moisture
Specific Requirements: Keep away from food, drink, and animal feed; prevent unauthorized personnel access
Exposure Limits: No occupational exposure limit established
Engineering Controls: Use of local exhaust ventilation or dust extraction recommended
Respiratory Protection: Approved particulate respirators for dusty operations
Skin Protection: Chemical-resistant gloves, lab coat or gown
Eye/Face Protection: Safety goggles or face shield
Hygiene Measures: Wash hands before breaks and after handling; avoid eating, drinking, or smoking in work area
Appearance: Off-white to pale yellow crystalline powder
Odor: Odorless
Molecular Weight: 267.28 g/mol
Melting Point: 160–165°C
pH: Neutral aqueous solution
Solubility: Soluble in water, slightly soluble in methanol, insoluble in organic solvents
Boiling Point: Decomposes before boiling
Vapor Pressure: Not significant at ambient conditions
Density: Approximately 1.39 g/cm³
Chemical Stability: Stable under recommended storage conditions
Reactivity: Does not react under normal use and storage
Possible Hazardous Reactions: May react with strong oxidizers
Conditions to Avoid: Exposure to extreme heat, moisture, strong acids or bases
Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides with combustion
Acute Toxicity: Oral LD50 in rats exceeds 2,000 mg/kg, showing low acute toxicity
Skin Corrosion/Irritation: Slight irritation possible on repeated contact
Serious Eye Damage/Irritation: Mild irritation may occur
Respiratory Sensitization: No evidence of respiratory sensitization in animal studies
Carcinogenicity: Not classified as carcinogenic according to IARC or OSHA
Mutagenicity: No mutagenic effects observed in AMES and other in vitro tests
Chronic Effects: No significant long-term hazards identified at occupational exposure levels
Ecotoxicity: Low toxicity to aquatic life at pharmaceutical use concentrations
Persistence and Degradability: Readily biodegradable in soil and aquatic environments
Bioaccumulation Potential: Low, due to water solubility and rapid degradation
Mobility in Soil: High mobility, unlikely to bind to soil
Other Adverse Effects: Lacks significant environmental hazard given typical quantities handled
Product Disposal: Small quantities can be washed away with plenty of water; large or bulk waste handled as chemical waste according to local, national, or international regulations
Container Disposal: Rinse empty containers before disposal; follow all applicable laws for hazardous or pharmaceutical waste
Precautions: Prevent contamination of surface water, ground water, and soil during disposal
Recommended Methods: Incineration in approved facilities or landfill in compliance with hazardous waste guidelines
UN Number: Not regulated for transport of dangerous goods
Proper Shipping Name: Voglibose
Transport Hazard Class: Not classified
Packing Group: Not applicable
Special Precautions: Transport in well-sealed and labeled containers, avoid mechanical shock, keep dry and protected from sunlight
Safety, Health, and Environmental Regulations: No specific regulatory classification as a hazardous substance on major chemical inventories (TSCA, EINECS, DSL, etc.)
Labelling Requirements: Not required under most jurisdictions, follow pharmaceutical GMP for labeling
SARA Title III: Not listed under hazardous categories
Other Local/National Regulations: Pharmaceuticals may be regulated under specific medicinal or controlled substance regulations in some regions; comply with applicable laws for workplace and environmental safety
