© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Vincristine Sulfate
Synonyms: Leurocristine sulfate, Oncovin
Chemical Formula: C46H56N4O10·H2SO4
CAS Number: 2068-78-2
Recommended Use: Pharmaceutical, chemotherapy agent
Supplier: Pharmaceutical manufacturer or distributor contact information
Classification: Acute toxicity (oral, dermal, inhalation); Carcinogenicity; Mutagenicity
Signal Word: Danger
Hazard Statements: Toxic if swallowed, inhaled, or absorbed through skin; May cause genetic defects; May cause cancer; Causes damage to organs through prolonged or repeated exposure
Precautionary Statements: Avoid breathing dust or vapors; Wear protective gloves, clothing, and eye protection; Do not eat, drink, or smoke when using this product; Wash thoroughly after handling
Chemical Identity: Vincristine Sulfate
Concentration: >98% Pure, remainder is water and small amounts of stabilizers
Impurities: Not significant at pharmaceutical grade; any impurities identified in Certificate of Analysis
Molecular Weight: 923.04 g/mol (including sulfate)
Inhalation: Remove person to fresh air; seek medical attention; provide oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing; rinse skin thoroughly with soap and water for at least 15 minutes; call poison control
Eye Contact: Flush eyes with plenty of water for at least 15 minutes, lifting lids; seek prompt medical care
Ingestion: Rinse mouth; do not induce vomiting; seek immediate medical attention
Medical Attention: Doctors should consider symptomatic and supportive care, monitor for signs of neurotoxicity or bone marrow suppression
Extinguishing Media: Water spray, carbon dioxide, foam, dry chemical
Specific Hazards: Emits toxic fumes under fire conditions; nitrogen oxides, carbon monoxide, sulfur oxides may be released
Protective Equipment: Full firefighting turn-out gear and self-contained breathing apparatus
Special Precautions: Avoid run-off from fire control entering drains or water courses
Personal Precautions: Evacuate area, ventilate, use suitable PPE including gloves, lab coat, and NIOSH-approved respirator
Spill Cleanup: Cover spills with absorbent paper or material, sweep up carefully, avoid raising dust, dispose in designated container
Decontamination: Clean contaminated surfaces with soap and water, wipe with appropriate disinfectant
Environmental Precautions: Prevent release into sewers or public waterways
Handling: Avoid contact with skin, eyes, and clothing; use within a chemical fume hood or biosafety cabinet; handle only by trained personnel familiar with handling cytotoxic drugs
Storage: Keep container tightly closed in a cool, dry, well-ventilated place away from incompatible materials; store at recommended temperature (usually 2-8°C); protect from light; use secondary containment
Exposure Limits: No occupational exposure limit established; minimize exposure as much as possible
Engineering Controls: Biological safety cabinet or chemical fume hood, closed system handling
Personal Protective Equipment: Chemical-resistant gloves (nitrile or latex), protective lab coat, safety goggles, shoe covers
Hygiene Measures: Do not eat, drink, or smoke while handling; wash hands thoroughly after handling; keep work clothes separate
Appearance: White or off-white crystalline powder
Odor: Odorless
pH (solution): 3.5–5.5
Solubility: Soluble in water
Melting Point: Not determined (decomposes)
Boiling Point: Not applicable
Vapor Pressure: Not applicable
Density: Not determined
Partition Coefficient: Not available
Flash Point: Not applicable
Stability: Stable under recommended storage conditions
Chemical Stability: Stable in original packaging, away from light and moisture
Reactivity: Not reactive under normal handling and storage conditions
Incompatible Materials: Strong oxidizers, acids, or bases
Hazardous Decomposition: Thermal decomposition may produce hazardous gases like nitrogen oxides, carbon oxides, sulfur oxides
Conditions to Avoid: Heat, light, prolonged exposure to air, contact with incompatible materials
Acute Toxicity: Highly toxic by inhalation, skin absorption, and ingestion; systemic toxicity includes neurotoxicity, myelosuppression, GI symptoms
Chronic Toxicity: Repeated exposure can cause nerve damage, immune suppression, reproductive toxicity
Carcinogenicity: Classified as possibly carcinogenic based on animal studies
Mutagenicity: Shown to cause genetic mutations in laboratory studies
Target Organs: Nervous system, bone marrow, GI tract
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Ecotoxicity: Highly toxic to aquatic organisms with potential for long-term adverse effects
Persistence and Degradability: Not readily biodegradable; may persist in environment
Bioaccumulative Potential: May accumulate in living organisms
Mobility: Expected to have limited mobility in soil
Other Adverse Effects: Avoid discharge into environment; follow local regulations for pharmaceutical disposal
Waste Treatment Methods: Collect and dispose of in accordance with local, regional, national, international regulations
Disposal Containers: Use specifically labeled cytotoxic waste containers with secondary containment
Incineration: High-temperature incineration method preferred for all cytotoxic materials
Unused Product: Return to supplier or authorized chemical disposal company
UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (Vincristine Sulfate)
Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Labeling: TOXIC
Transport Precautions: Ship as hazardous substance in leak-proof containers; prevent accidental release; notify carrier if any spillage occurs in transit
Regulatory Status: Subject to specific national and international regulations for pharmaceuticals and cytotoxics
OSHA: Regulated as hazardous
TSCA: Not listed
WHMIS (Canada): Classified as D1A (VERY TOXIC), D2A (VERY TOXIC)
REACH: Exempt as medicinal product, but component registration may apply
Other Requirements: Ensure safety data and labeling compliance with local pharmaceutical and hazardous chemical guidelines
