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Product Name: Vecuronium Bromide
Chemical Name: 1-(3,17-diacetoxy-2β-piperidino-5α-androstan-16β-yl)-1-methylpiperidinium bromide
CAS Number: 50700-72-6
Synonyms: Norcuron, Vecuronium, Norcuronium Bromide
Recommended Use: Neuromuscular blocking agent for general anesthesia
Manufacturer Information: Pharmaceutical supplier details available on packaging
Emergency Phone Number: Refer to local poison control services or national health emergency numbers
Restrictions on Use: Prescription-only, hospital or clinical environment
Classification: Acute toxicity, Category 3 (oral); Acute toxicity, Category 3 (dermal); Eye irritation, Category 2A
Signal Word: Danger
Hazard Statements: Toxic if swallowed, toxic in contact with skin, causes serious eye irritation
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Do not breathe dust, wash thoroughly after handling, wear protective gloves and eye protection, avoid release to the environment, call poison center or doctor immediately if exposed
Description of Hazards: Severe effects on neuromuscular function, potential respiratory depression, may cause convulsions or unconsciousness in overdose
Chemical Name: Vecuronium Bromide
CAS Number: 50700-72-6
Concentration: 98–100% (pure compound)
Impurities: None reported at pharmacological concentrations
Other Components: Not applicable, single active ingredient
Description: Crystalline powder, white or off-white
General Advice: Move patient to fresh air, keep under medical observation, monitor breathing closely
If Inhaled: Remove from exposure, begin artificial respiration if breathing stops, seek immediate medical attention
If on Skin: Remove contaminated clothing, rinse skin with plenty of water and soap for at least 15 minutes, get medical help
If in Eyes: Rinse cautiously with water for at least 15 minutes, remove contact lenses, seek urgent ophthalmic attention
If Swallowed: Do not induce vomiting, rinse mouth, seek medical attention immediately, provide supportive treatment
Advice to Physician: Provide symptomatic and supportive care, monitor respiratory and neuromuscular status, administer ventilatory support if needed
Flammability: Not highly flammable, but powder may form combustible dust-air mixtures
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: High volume direct water jets may spread contamination
Specific Hazards: Burning may produce toxic gases: carbon monoxide, hydrogen bromide, nitrogen oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective suit
Special Procedures: Prevent run-off to waterways, ventilate area
Fire & Explosion Data: Avoid dust formation and sources of ignition
Personal Precautions: Evacuate area, use personal protective equipment including gloves, goggles, respirator
Environmental Precautions: Prevent entry into drains, waterways, and soil
Cleanup Methods: Collect spilled material with inert absorbent, sweep or scoop up carefully, avoid generating dust, place in clearly labeled closed container for disposal
Decontamination: Wash surfaces with water and detergent, ventilate area
Reporting: Notify relevant authorities if significant environmental contamination occurs
Handling Precautions: Avoid contact with skin, eyes, and clothing, use engineering controls to minimize airborne concentrations, use only in well-ventilated areas, prevent dust formation
Storage Requirements: Store in a secure, locked facility, prevent unauthorized access, keep container tightly closed, store at controlled room temperature—15–30°C (59–86°F), protect from light and moisture
Incompatible Substances: Strong oxidizers, acids
Storage Container Materials: Use original container, with tamperproof seal if possible
Storage Stability: Maintain original labeling and batch tracking
Exposure Limits: No established workplace exposure limits, minimize exposure to dust or aerosols
Engineering Controls: Local exhaust ventilation, biological safety cabinets for weighing or compounding
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or neoprene), full-body gown, eye/face protection (goggles or face shield), disposable particulate respirator (N95 or higher) if risk of airborne exposure
Hygiene Measures: Do not eat, drink, or smoke in handling areas, wash hands after use, remove contaminated clothing immediately
Environmental Controls: Prevent release to the environment, use spill containment systems
Appearance: White or nearly white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: ~4.0 (1% solution in water)
Melting Point: >220°C (decomposes)
Boiling Point: Decomposes before boiling
Flash Point: Not determined (solid compound)
Solubility: Soluble in water, slightly soluble in ethanol, insoluble in chloroform
Specific Gravity/Density: Not determined
Vapor Pressure: Negligible at room temperature
Viscosity: Not applicable (solid compound)
Partition Coefficient (log Kow): Not available
Explosive Properties: Not explosive under normal conditions
Oxidizing Properties: Not an oxidizer
Chemical Stability: Stable at room temperature and under recommended storage conditions
Reactivity: No hazardous polymerization
Conditions to Avoid: Excess heat, moisture, incompatible substances, light exposure
Incompatible Materials: Strong acids, bases, oxidizers
Hazardous Decomposition Products: Carbon oxides, hydrogen bromide, nitrogen oxides when exposed to fire
Possibility of Hazardous Reactions: No dangerous reactions known under normal use
Acute Toxicity: Oral LD50 (rat) 0.29 mg/kg; Severe toxicity with small doses
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Symptoms of Exposure: Muscle paralysis, respiratory depression, bradycardia, hypotension, salivation, allergic reactions
Chronic Effects: No data for long-term continuous exposure, not classified as carcinogenic, mutagenic, or reprotoxic based on available information
Sensitization: May cause allergic skin reactions in susceptible individuals
Target Organs: Neuromuscular system, respiratory system
Other Toxicity Data: Extremely potent in humans, intended for controlled medical use only, rapid onset of toxicity after exposure
Toxicity to Aquatic Organisms: Harmful to aquatic organisms, avoid large releases
Persistence and Degradability: Likely to undergo slow biodegradation in the environment
Bioaccumulative Potential: No evidence for significant bioaccumulation in aquatic species
Mobility in Soil: Expected to have limited mobility due to solubility and charge
Other Adverse Effects: Avoid uncontrolled release to environment to prevent bioactivity in non-target species
Ecotoxicity Data: Not well-studied, handle with care to prevent water system contamination
Waste Disposal Methods: Treat as hazardous pharmaceutical waste, incinerate in approved facility, follow local, regional, and national regulations
Disposal of Containers: Triple rinse with suitable solvent, crush or puncture, dispose in accordance with hazardous waste procedures
Precautions for Disposal: Do not allow product or contaminated packaging to enter drains, watercourses, or landfill
Unusable Product: Return unused portions to original supplier or designated collection point for professional incineration
UN Number: UN 2811 (Toxic solid, organic, n.o.s.)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Proper Shipping Name: Vecuronium Bromide, or Toxic solid, organic, n.o.s. (contains Vecuronium Bromide)
Labels: Toxic
Special Precautions: Keep container tightly closed, transport in secure, upright position, do not expose to heat
Regulatory Guidance: Comply with local and international transport rules for toxic substances; handle and label carefully to avoid accidental exposure
US Federal Regulations: Controlled substance (Schedule II in the US), product regulated under OSHA hazardous chemical requirements
EU Regulations: Listed as a controlled pharmaceutical, subject to workplace safety requirements
Canada: Prescription drug, covered by hazardous products regulations
Other National Regulations: Product subject to medical and pharmaceutical handling laws, hazardous material transport rules worldwide
GHS Classification: Acute toxicity (oral, dermal), Eye irritant
Safety, Health and Environmental Regulations: Detailed in all applicable national, regional, and local rules for potent pharmaceuticals and cytotoxic agents
