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Product Name: Vancomycin Hydrochloride
Chemical Name: Vancomycin Hydrochloride
Synonyms: Vancocin, Lyphocin
CAS Number: 1404-93-9
Recommended Use: Antibiotic for treatment of serious gram-positive infections
Manufacturer: Pharmaceutical companies specializing in antibiotics
Contact Information: Refer to packaging or regulatory documentation for manufacturer’s emergency contact details
Emergency Telephone: Refer to country-specific poison control or emergency number listed on product packaging
GHS Classification: Acute toxicity (oral, inhalation, dermal), eye irritation, respiratory sensitizer, skin sensitizer
Label Elements: Signal word: Warning
Hazard Statements: Harmful if swallowed or inhaled. Can cause allergic skin reactions. Risk of serious damage to eyes. Possible reproductive toxicity.
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Avoid contact with skin, eyes, and clothing. Prevent inhalation of dust and aerosols. Use personal protective equipment (PPE) as required. Wash thoroughly after handling.
Other Hazards: Occupational exposure may trigger hypersensitivity responses in predisposed people. Chronic exposure may affect kidney and hearing function.
Substance: Vancomycin Hydrochloride
Concentration: Active pharmaceutical ingredient typically over 98% purity
Chemical Formula: C66H75Cl2N9O24·HCl
Impurities: Process-related organic and inorganic impurities under pharmacopoeial limits
Additives: Some formulations may include excipients or bulking agents; check product documentation for details
Exposure Limits: No occupational exposure limits established for finished pharmaceutical. Handle as a potent pharmaceutical compound.
Inhalation: Remove to fresh air. Seek medical attention for symptoms including difficulty breathing, coughing, or throat irritation.
Skin Contact: Flush skin immediately using plenty of water and mild soap. Remove contaminated clothing. Watch for delayed allergic reactions.
Eye Contact: Rinse eyes gently but thoroughly with lukewarm water for at least 15 minutes, ensuring eyelids are held open. Seek specialist medical evaluation if irritation persists.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek immediate medical attention, particularly if symptoms develop.
Most Important Symptoms and Effects: Allergic skin or respiratory reactions, severe irritation, headache, dizziness, nephrotoxicity.
Medical Attention: Provide symptomatic and supportive treatment. Present safety data to healthcare providers.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam as appropriate for area.
Unsuitable Extinguishing Media: Direct stream of water may cause risk of spreading fire in surrounding materials.
Specific Hazards Arising from Chemical: Hazardous fumes may include carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride.
Protective Equipment and Precautions: Wear self-contained breathing apparatus and full protective suit.
Special Procedures: Remove containers from area if safe. Cool adjacent containers with water spray. Prevent runoff from entering drains.
Personal Precautions: Wear gloves, safety goggles, and laboratory coats. Avoid dust formation and inhalation.
Emergency Procedures: Evacuate unnecessary personnel. Ventilate area.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Keep product out of streams, sewers, and soil.
Methods for Clean-Up: Sweep up and shovel material using non-sparking tools. Avoid raising dust. Place in closed containers for disposal. Decontaminate spill site with suitable detergent solution.
Handling: Keep containers tightly closed. Limit access to trained personnel. Practice good hygiene and use engineering controls such as local exhaust.
Storage: Store in cool, dry, and well-ventilated areas. Protect from light, moisture, and incompatible materials such as strong oxidizing agents.
Incompatible Materials: Strong bases, acids, and oxidizing substances.
Safe Transfer: Employ proper transfer and containment procedures to minimize exposure risks.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels low.
Personal Protective Equipment: Wear chemical splash goggles, nitrile gloves, laboratory coat or overall, and respiratory protection if dust is generated.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling. Maintain eye wash and safety shower facilities in work area.
Environmental Exposure Controls: Employ spill control and containment to protect the workplace environment from contamination.
Monitoring: Biological and workplace exposure monitoring may assist in managing potential risks for personnel with allergies or chronic health issues.
Appearance: White or off-white amorphous powder
Odor: Odorless
pH: 2.5–4.5 (1% solution in water)
Melting Point/Range: Decomposes before melting
Boiling Point: Information not available; decomposes on heating
Flash Point: Not relevant—non-volatile solid
Solubility: Soluble in water; minimal solubility in common organic solvents
Vapor Pressure: Negligible at ambient temperature
Density: Approximately 1.7 g/cm³
Partition Coefficient (log P): Not applicable for non-volatile solids
Chemical Stability: Stable under normal conditions (dry, room temperature, protected from light)
Possibility of Hazardous Reactions: None anticipated with recommended storage and handling
Conditions to Avoid: Moisture, elevated temperatures, and light exposure
Incompatible Materials: Strong oxidizing agents and bases
Hazardous Decomposition Products: Thermal decomposition can yield carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride
Acute Toxicity: Oral LD50 (rat): 5000 mg/kg (literature values); data for inhalation and dermal routes limited
Skin Corrosion/Irritation: May provoke irritation on repeated or prolonged exposure
Eye Damage/Irritation: Severe, irreversible injury possible with direct contact
Respiratory Sensitization: Known to cause allergic reactions in sensitive individuals
Germ Cell Mutagenicity: No evidence from available data; use with caution
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: Noted embryo-fetal toxicity in animal studies at high doses
Other Information: Chronic exposure can damage auditory, renal, and nervous systems. Frequent monitoring recommended for exposed workers.
Ecotoxicity: Can be harmful to aquatic organisms in high concentrations; impacts assessed as moderate based on active pharmaceutical class
Persistence and Degradability: Poorly biodegradable in water; degradation in soil and sludge occurs slowly
Bioaccumulative Potential: Not expected to bioaccumulate based on low log Kow
Mobility in Soil: Moderate mobility; may leach into groundwater
Other Adverse Effects: Antimicrobials entering water systems may alter microbial ecology, encourage resistance
Disposal Methods: Collect and dispose of as hazardous pharmaceutical waste in accordance with local, state, and national regulations
Contaminated Packaging: Treat as unused product. Triple-rinse and render packaging unusable before landfilling or incinerating
Special Precautions: Avoid disposal via sewer or regular solid waste; prevent material from reaching public water systems
UN Number: Not regulated as a dangerous good for road, rail, air, or sea
Proper Shipping Name: Non-regulated
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Environmental Hazards: Avoid large scale release; use spill control methods during transport
Special Precautions for User: Protect from moisture and physical damage during transit. Carry safety documentation when shipping research or bulk material internationally.
US Regulations: Vancomycin Hydrochloride appears on the FDA Orange Book; not listed as a controlled substance. OSHA: Handle as hazardous under Hazard Communication Standard.
European Union: Covered by REACH regulation for workplace safety and environmental release. Not classified as a carcinogen or PBT/vPvB chemical.
Other International: Regulations may vary by country; always consult specific regulatory agencies for local definitions. Ingredient may appear on inventories such as Australia AICS, Canada DSL.
Workplace Control: Employers have duty to provide training, hazard information, and proper protection for workers.
Labeling Requirements: Containers must be labeled with chemical identity, hazard warnings, and manufacturer details as per GHS guidelines.
