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Vancomycin Hydrochloride: Beyond a Lifesaver

Historical Development

Vancomycin hydrochloride stepped into the world of medicine during the 1950s as a response to the growing wave of penicillin-resistant bacterial infections. It came from the actinomycete Amycolatopsis orientalis, which was first discovered in Borneo soil. Researchers set out to tackle life-threatening complications from staph and other Gram-positive bacteria. In the years since, vancomycin stood as a vital last-resort antibiotic, especially after reports in the late 1980s and 1990s of hospital-acquired infections that shrugged off older drugs. My own introduction to vancomycin arose in the infectious disease wards, where it often marked the difference between a steady recovery and a rapidly worsening, untreatable infection. Generations of hospital staff saw it become a keystone in intensive care, not just a backup plan.

Product Overview

Vancomycin hydrochloride comes into use most often as a white to off-white, amorphous, hygroscopic powder. Pharmaceutical formulations include standard powder for solution, or a lyophilized form that can endure shipping and storage. Intravenous preparations serve as the workhorse product in hospital settings, though oral forms exist to handle gut-limited infections like Clostridioides difficile. The powder dissolves well in water for injection, making rapid preparation possible. Marketed under trade names such as Vancocin, Vancomycin-Leucosin, and others, each manufacturer provides it in slightly different sizes or concentrations, but the underlying drug remains the same core molecule sourced from fermentation. This medicine often carries prominent labeling that warns about overdose risks, underlining the drug's narrow therapeutic window and the real possibility of kidney damage or hearing loss from misuse.

Physical & Chemical Properties

Vancomycin hydrochloride has a hefty molecular formula: C66H75Cl2N9O24•HCl. In its pure form, it appears as a hygroscopic powder that easily attracts water from the air, making it tricky to store without moisture control. Vancomycin boasts multiple ionizable groups, and its hydrochloride salt ensures it dissolves quickly in water. Its high molecular weight, numerous aromatic rings, and glycopeptide backbone set it apart from smaller molecular weight antibiotics. It has a melting point above standard autoclave temperatures, so dry heat does little to affect its structure as long as humidity remains low. Chemists looking at stability tests found the drug stable under cold-storage conditions for years, if protected from light and humidity. UV-Vis spectra and infrared analyses both reveal the complex network of hydroxyl, amino, and carbohydrate groups giving vancomycin its biological punch.

Technical Specifications & Labeling

Each vial of vancomycin hydrochloride for injection carries precise instructions regarding reconstitution, specific solvent compatibility, pH range, and final concentration. Most standard vials come filled with powder equivalent to 500 mg or 1,000 mg of vancomycin, ready for mixing with sterile water or saline. Labeling also flags key risks: rapid infusion triggers “red man syndrome,” so drip rates get set by strict protocols. Pharmacists and nurses receive explicit tables describing compatible IV fluids, as well as timeframe limits for reconstituted solutions. Storage advice calls for refrigeration between 2°C to 8°C or prompt use after reconstitution, tightly controlling exposure to air and light. Labels mandate batch number tracing, tamper-evident seals, and expiry dates that reflect time post-manufacture and post-reconstitution. Many hospital protocols require double-checking by independent nursing staff due to the strong toxicity linked to both underdosing and overdosing.

Preparation Method

Commercial vancomycin hydrochloride starts its life through fermentation. The original actinomycete gets grown under carefully selected nutrient and temperature conditions in deep fermentation tanks, producing vancomycin as a secondary metabolite. After extraction, the crude antibiotic mixture passes through a series of filtrations, adsorptions, and crystallizations to reach pharmaceutical grade. Final processing involves transitioning to the hydrochloride salt form, which produces crystallized vancomycin hydrochloride with the desired water solubility and pharmacological profile. Each batch undergoes extensive purity testing, including chromatographic and spectrophotometric methods, to root out any unexpected fermentation byproducts or residual proteins. Manufacturing plants carry out these multi-day processes under strict containment to protect workers from dust or accidental exposure. Large-scale synthesis relies on constant monitoring, not just to hit purity marks but also to meet international quality certifications demanded by both regulators and major hospital buyers.

Chemical Reactions & Modifications

Vancomycin’s large, complex glycopeptide framework challenges medicinal chemists attempting any sort of modification. Its core resists hydrolysis and reduction, yet side chains allow strategic tweaking to boost pharmacological activity or sidestep resistant bacterial enzymes. Medicinal chemistry labs often experiment with semi-synthetic derivatives. Teicoplanin stands as one such derivative, boasting improved clinical features. Broader research efforts include conjugating the molecule to targeting ligands, hoping to direct vancomycin precisely to infected tissues and reduce toxic side effects elsewhere in the body. Standard laboratory treatments use vancomycin’s ionizable groups to attach fluorescent tags for tracing its path within bacterial cells. Chemical modifications seek to dodge increasingly common vancomycin-resistant organisms, especially Enterococcus and some species of Staphylococcus. Recent years also saw experimentation with liposomal formulations and nanoparticles acting as delivery vehicles, aiming to overcome both solubility issues and the frustrating barrier of bacterial biofilms. These developments remain on the cutting edge and often emerge from collaborations between academic centers and big pharma’s medicinal chemistry divisions.

Synonyms & Product Names

Vancomycin hydrochloride wears many names, depending on which country or company you check. Some call it Vancocin, a name tied to original branding. Hospital supply catalogs list it as Vancomycin HCl (USP grade), Vancomycin-Leucosin, or even simply generic “vancomycin injection.” Research supply houses often call it “vancomycin hydrochloride monohydrate,” to distinguish from rarer forms. Journals and textbooks sometimes refer to it as a “glycopeptide antibiotic” or “antibiotic 05865.” The International Nonproprietary Name system, the United States Pharmacopeia, and the European Pharmacopoeia all list vancomycin hydrochloride in their drug monographs, demanding specific structural and impurity profiles for legal distribution. Synonyms might confuse those just starting clinical training, but seasoned pharmacists and infectious disease specialists instantly recognize the various aliases, especially when double-checking global supply chains during shortages or recalls.

Safety & Operational Standards

Administering vancomycin calls for vigilance. Dosing errors, contamination, and infusion mistakes all lead to severe patient harm, sometimes requiring dialysis or causing permanent hearing damage. Most hospital protocols require baseline and repeat kidney function labs for anyone on a multi-day vancomycin regimen. Pharmacists ensure reconstitution and dilution steps follow aseptic technique, logging each lot number and expiration in the patient’s record. Nurses keep a close eye for early signs of “red man syndrome,” which causes rash, flushing, and potentially dangerous drops in blood pressure if the infusion runs too fast. Regulatory guidelines like USP Chapter <797> and the European Medicines Agency’s quality standards both direct how staff should compound, store, and deliver each dose. Staff rely on personal protective equipment to shield from accidental splashes or powder inhalation, particularly during bulk compounding in pharmacy clean rooms. Facilities inspect and audit their vancomycin handling logs frequently, striving for zero errors. Everyone involved knows the stakes; slip-ups carry real risks for both patients and staff.

Application Area

Doctors reserve vancomycin for severe infections caused by Gram-positive bacteria, especially those that defeated older drugs like methicillin. The most familiar use is in treating MRSA (methicillin-resistant Staphylococcus aureus), a hospital “superbug” resistant to almost every standard antibiotic. Beyond MRSA, vancomycin goes up against enterococci, pneumococci, and other deep-seated bacterial invaders, especially in bone infections, heart valve infections, joint replacements, and in cases where implanted medical devices get colonized. In pediatric and adult intensive care settings, vancomycin often forms part of empiric treatment for pneumonia, sepsis, and meningitis while labs work on precise identification. Oral vancomycin stands apart as one of the go-to agents for life-threatening Clostridioides difficile colitis, as it stays within the gut and avoids being absorbed into the bloodstream. My own practice saw vancomycin serve as a vital fallback drug once simpler options failed, or when the patient’s chart warned of deadly drug allergies. Its reach extends from bustling urban hospitals to field clinics worldwide, reflecting its role as a backbone of modern infection control.

Research & Development

Drug development cycles revolve around adapting vancomycin to emerging bacterial threats. Microbiology labs began mapping resistance genes in hospitals decades ago, prompting urgent calls for new derivatives. Modern research leans into structure-guided drug design, using crystallography and molecular modeling to home in on weak spots in both bacterial cell walls and vancomycin’s own structure. Some teams work on “lipoglycopeptides,” tweaking vancomycin’s tail to take out resistant bugs while minimizing kidney stress. Other projects target delivery methods, exploring inhaled or topical vancomycin preparations for hard-to-reach infections. The challenge never fades: resistant strains keep cropping up, and the world’s reliance on vancomycin for so many critical infections means that new second-line drugs remain urgently needed. Collaborative projects between universities, government agencies, and pharmaceutical giants foster a global attack, not just on bacterial resistance, but also on toxicity and cost—it’s a race to preserve effectiveness while managing side effects and broadening patient access.

Toxicity Research

Vancomycin’s power comes with a cost. Early studies linked it to nephrotoxicity, showing kidney injury rates that climb even higher if combined with other common hospital drugs like aminoglycosides. Ototoxicity followed as the second main concern, particularly among elderly patients or those with pre-existing hearing problems. Researchers traced the toxic effects to both the parent drug and certain impurities, prompting even tighter purity standards from regulators. Blood level monitoring now stands as routine for longer courses or higher doses, especially in populations at risk of organ dysfunction. Toxicology teams perform rigorous animal experiments and in vitro studies, not just to define safe exposure limits, but to search for genetic markers predicting higher risk. Real-world surveillance continues, feeding case reports and dosing guidelines that evolve with every unexpected outcome. Hospitals maintain rapid response pathways for reporting suspected adverse reactions, building a foundation of patient safety on every dose delivered.

Future Prospects

Vancomycin’s story isn't nearing its end. Each surge in resistance pushes healthcare workers and scientists to expand the molecule’s utility. The future promises new “next-gen” glycopeptides with customized transport inside the body and improved binding to mutated bacterial targets. Many researchers imagine smarter drug delivery devices, allowing tailored doses while minimizing systemic toxicity: think implant coatings or slow-release depot formulations. Gene-editing approaches surface sporadically in research circles, custom-modifying the producing actinomycete or stitching in enzymes that churn out enhanced molecules. Community efforts rally around antimicrobial stewardship, looking to curb overuse and preserve vancomycin’s precious role for the sickest patients. Alongside hospital partners, manufacturers invest in high-volume, high-purity fermentation lines, readying for surges in demand during epidemic outbreaks. The next chapters hinge on staying one step ahead of evolving microbes, bridging the gap between bench science and bedside care.




What is Vancomycin Hydrochloride used for?

Fighting Infections That Don’t Play by the Rules

Antibiotics changed medicine forever, but bacteria have been fighting back for decades. Some of the nastiest ones, like methicillin-resistant Staphylococcus aureus (MRSA), don’t respond to regular treatments. Too often, the standard options just don’t cut it. That’s where vancomycin hydrochloride steps in. Hospitals keep it on hand for a reason—it’s one of the last lines of defense against infections that shrug off other drugs.

Stories From the Front Lines

Doctors and nurses see infections every day that nobody ever expects. A friend of mine, an ICU nurse, tells me it’s not always the frailest patients who get hit hardest—sometimes it’s people who walk into the hospital with what looks like a mild skin infection. In the lab, those bacteria sometimes laugh at penicillin or cephalosporin. The pharmacy gets the call, and vancomycin goes into the IV. Over the next few days, the patient can finally turn a corner.

This medicine matters most in places where bacteria gather and swap resistance tricks, like in surgical wards, cancer units, and intensive care. It’s also a lifeline for people with prosthetic joints, central lines, or catheters who get hit with dangerous infections. Without vancomycin, a simple cut or a sore throat could spiral out of control. MRSA alone leads to thousands of deaths each year in the United States, according to the Centers for Disease Control and Prevention.

Why We Need to Protect It

Vancomycin is powerful, but it comes at a cost. It’s not gentle on the kidneys, and it can cause side effects like skin rash and low platelet counts. Long infusions and careful blood tests are part of the routine. For many patients, it’s the only shot left, so doctors work hard to keep its power intact.

I remember a professor telling our class that using vancomycin without thinking was like opening the last present under the tree before Christmas morning. Overuse invites new bugs to survive the onslaught and pass their tricks on to others. The CDC and other public health experts stress the same point: sudden, reckless prescriptions shorten the usefulness of this drug for everyone. So, infectious disease teams watch cultures, test sensitivities, and only reach for vancomycin when nothing else works.

Changing Course

Many hospitals now run “antibiotic stewardship” programs. These teams track infections, teach doctors to recognize cases where other antibiotics will work, and suggest stopping vancomycin once the real cause turns out to be friendlier than expected. Technology points to faster lab tests that can tell whether vancomycin is needed within hours, not days.

People outside the medical world can help by not pushing for antibiotics for minor illnesses and finishing prescriptions when needed. Simple tricks, like handwashing, cleaning surfaces, or covering cuts, go a long way toward avoiding the sort of infection that pushes someone into a hospital bed hooked up to a vancomycin drip.

The Road Ahead

Every use matters. Vancomycin hydrochloride holds its ground, fighting for those too sick for other antibiotics to help. Its story isn’t about magic bullets—it’s about hard lessons learned on busy wards and careful choices made by people who know what’s at stake. Everyone who takes medicine—doctor, nurse, patient—has a part to play in keeping this tool available for those who need it most.

What are the common side effects of Vancomycin Hydrochloride?

Facing the Facts on Vancomycin

Vancomycin isn’t a new player in hospital wards. Doctors rely on it when tough bacteria, like MRSA, just don’t respond to other antibiotics. This drug brings relief for many people, but it isn’t all smooth sailing. While you might hear only about its power to knock out infections, the reality is that it can bring a set of side effects most folks wouldn’t want to ignore. Working in healthcare, I’ve seen people bounce back because of vancomycin—I've also listened to patients complain about symptoms, sometimes so intense we'd have to rethink their treatment.

Common Side Effects: What Really Happens

The most talkative complaint is the famous “Red Man Syndrome.” Get vancomycin through a drip too fast and patches of red blotchy skin, discomfort, and sometimes low blood pressure can follow. It isn’t an allergy—just the way the body responds to quick infusions. Most nurses slow down the drip or switch up the dose, but seeing someone flush red from head to toe is memorable. A survey across several hospitals pinned the occurrence as high as 47% in rapid infusions. Slower administration tends to keep the flush away.

Nausea, vomiting, and diarrhea also rank high. These symptoms show up in plenty of folks, especially those on long courses or with already upset stomachs. It doesn’t take a health professional to know how draining constant nausea feels—you start skipping meals, lose sleep, find life getting smaller one uncomfortable day at a time.

Hearing damage (ototoxicity) sounds like a rare complication, but it’s real. In my work, tracking kidney and hearing function comes up as routine practice. Even so, I’ve sat next to anxious patients who notice new ringing or muddled hearing. It hits older adults and kids hardest, especially if other drugs in the mix also stress the ears. Lab studies show that vancomycin levels above the safe window push this risk higher. Most hospitals take regular blood draws to keep tabs on it, but not every spike gets caught in time.

Kidney trouble (nephrotoxicity) is the big reason why doctors follow up with so much blood work. Overdosing isn’t always about too much medicine—sometimes it’s a low water intake or adding other kidney-straining drugs. Data shows rates of kidney issues with vancomycin floating between 5-43%, especially in the sickest patients. It’s not just a number. I’ve seen families facing sudden dialysis or a longer hospital stay. Good hydration, careful dosing, and stopping other kidney-harsh medications drop this risk, but it doesn't wipe it away completely.

Thinking Ahead: What Actually Helps?

More people recognize the need to monitor themselves more closely with vancomycin. Keeping daily notes on new symptoms matters more than waiting to speak up at the next clinic visit. Acting fast gives care teams the chance to pivot and keep problems from getting out of hand.

Teamwork helps smooth the rough patches. Pharmacists can check doses, nutritionists can fight stomach upset, and doctors keep one eye on lab numbers. Patients with hearing aids or kidney concerns do best in clinics that track things closely, not just at the start but all through treatment.

There’s no perfect solution, but facing side effects openly gets better results than hoping for the best. Transparent conversations, early interventions, and support for anyone on vancomycin can make a tough treatment feel just a little less risky.

How is Vancomycin Hydrochloride administered?

Understanding the Basics

Vancomycin Hydrochloride stands apart from many other antibiotics. This isn’t a pill you can grab from the pharmacy and swallow with a sip of water. Doctors rely on it for stubborn infections, especially those caused by bacteria like MRSA. It’s a real weapon when many others fail to work. The way it gets into the body matters as much as the drug itself.

How Vancomycin Gets Delivered

Most people receive Vancomycin through a drip—what healthcare professionals call an intravenous infusion. The process feels more involved than popping a pill. Nurses attach a plastic tube to a vein, usually in the arm or hand. The liquid solution flows directly into the bloodstream, letting the medicine start fighting bacteria right away.

Hospital teams take their time with the infusion. Pushing Vancomycin too quickly can cause severe reactions. Red Man Syndrome is one of those—patients suddenly notice flushing, itching, or a rash on the upper body. This shows why careful control over the injection rate really matters. Hospitals often use a pump to keep things smooth and steady, usually over 60 to 120 minutes.

Oral Administration Has Its Place—But Only Sometimes

Doctors do turn to Vancomycin capsules or solutions for certain specific situations, mostly to target infections in the gut, like Clostridioides difficile. Swallowed doses do not get absorbed into the bloodstream. Instead, the compound stays inside the intestines. That’s exactly the point when fighting bacteria living there, preventing the spread while minimizing effects on the rest of the body.

Outside this intestinal use, oral Vancomycin just doesn’t do the job. With severe infections elsewhere, only intravenous (IV) administration delivers the knock-out punch.

Why Monitoring Always Matters

Anyone who’s seen hospital medicine up close can tell you: strong antibiotics need strong safeguards. Vancomycin is no exception. Blood draws check how much medicine lingers in the body. Too little, and bacteria survive. Too much, and kidneys take a beating. Drug levels guide doctors in adjusting timing and dosage, keeping things in the safe zone.

Other medications, age, and kidney function all play a part here. Older adults and people with kidney problems often require extra attention to avoid complications. I remember seeing doctors pause to confer about an elderly patient, reviewing numbers before the nurse could hang the next bag of medicine. Safety before speed—always.

The Challenge of Antimicrobial Resistance

Resistant bacteria keep pushing medicine to adapt, making smart use of drugs like Vancomycin more crucial. Misuse—giving a dose “just in case” or not finishing a prescribed course—feeds this cycle. Healthcare teams count on follow-up, patient education, and rapid lab results to guide therapy. Infection control staff often review every case to make sure Vancomycin is the right call.

Room for Improvement

Many hospitals look for ways to reduce mistakes with IV infusions by using barcoding, reminders, and precise electronic orders. Training helps new nurses avoid the pitfalls of rushing an infusion. The healthcare system as a whole has also stepped up stewardship programs, reviewing each prescription for necessity and best practice.

Patients have an important role—they ask about side effects, watch for symptoms, and communicate changes. Medicine works best as a partnership, not just a prescription.

Final Thoughts

No one wants to spend more time in a hospital bed than necessary. Vancomycin saves lives when other drugs come up short. Knowing why the delivery method matters—and how careful administration protects patients—gives families real confidence. Shared understanding, ongoing checks, and attention to detail keep this medical heavyweight working where it’s needed most.

What should I do if I miss a dose of Vancomycin Hydrochloride?

Why Skipping a Dose Isn’t Just a Small Slip

People using Vancomycin for infections often feel overwhelmed by the schedule. Life gets busy, alarms get ignored or forgotten, and missing a dose can happen to anyone. What most don’t realize: with antibiotics like Vancomycin, missed doses can spell trouble. That gives bacteria a chance to fight back, and it nudges the threat of resistance a little further down the road. I’ve spoken with health workers and pharmacists, and they see this more than you’d expect.

Vancomycin works by stopping the growth of stubborn bacterial infections. Doctors prescribe it when less powerful antibiotics have failed or for infections that won’t budge. Skipping doses lets the bacteria regroup, which can mean symptoms drag on longer or the infection grows tougher to treat. Research highlights this risk, especially among people switching from IV to oral antibiotics or those with longer treatment courses.

What To Do If You Miss a Dose

For those using Vancomycin at home, you’ll want simple advice. Take the missed dose as soon as you remember, as long as it’s not close to the next scheduled time. If you’re almost due for the next one, skip the missed dose instead of doubling up. Doubling up leads to side effects like kidney issues or hearing changes, both real dangers with Vancomycin. That’s not something to take lightly — these side effects show up even with short-term misuse. Based on FDA guidance and modern clinical practice, you stick to your regular schedule as much as possible and avoid racing to catch up.

Every detail matters with this drug. The timing, the amount, even food and drink can play a role. Stay consistent with how you take it: some people get it by IV in a clinic, others swallow the liquid or capsule at home. Every method asks for strict timing, though, and nurses will often stress this point. I’ve seen people try to “make up” for late doses, thinking it’s like missing a vitamin – it’s not. That’s a shortcut to trouble. If you ever feel lost or unsure, call a pharmacist. They field these calls every single day and would rather repeat themselves than see someone wind up in the hospital for avoidable mistakes.

Preventing Missed Doses

Setting reminders on your phone or keeping a treatment diary takes just a few minutes but makes missing doses far less likely. People who write down or check off each dose keep to the schedule better. For families or older folks, involving a family member or asking for nurse follow-ups increases the chances that nothing slips through the cracks. Hospitals and pharmacies often have simple sheets or apps to help track doses for people who struggle to remember. Don’t let embarrassment stop you from asking for tools or support — pharmacists want you healthy, not ashamed.

When to Call for Help

If you’ve missed more than one dose or feel sick, weak, or notice odd ringing in your ears, pick up the phone. Some infections get picky about missed treatments, especially those involving your heart, bones, or joints. Delaying help risks hospital trips; dealing with it early saves pain and stress. Trust your body and trust your care team more than internet tips or second-hand advice. Doctors weigh your other health issues together with any missed doses and will help keep things on track.

Vancomycin saves lives but asks for respect. Getting better sometimes means making tough changes to daily routine, but no infection clears up from a half-finished plan. Reach out. Ask for backup. Health always deserves it.

Are there any drug interactions with Vancomycin Hydrochloride?

Understanding Vancomycin in a Real-World Setting

Vancomycin Hydrochloride gets prescribed for tough bacterial infections, especially the kind that laugh in the face of ordinary antibiotics. Folks landing in the hospital with MRSA or other serious bugs often hear the name vancomycin, and for good reason. It usually works when others fail. Still, even a heavyweight like vancomycin can run into problems when it’s teamed up with other drugs. I’ve seen this play out all too often on the hospital floor, where the pharmacy team sweats over every IV drip hung up for the next shift.

Common Drug Interactions to Watch For

The big red flag with vancomycin always centers on kidney health. Giving it with other medications that have a reputation for being tough on kidneys makes trouble more likely. Think aminoglycosides like gentamicin. Both can be life-saving, but together, the kidneys start waving a white flag. I remember a patient on a triple-antibiotic cocktail who soon started showing rising creatinine numbers on daily blood draws. The culprit? The combination of vancomycin with an aminoglycoside.

Diuretics belong to this caution list too. When someone takes a loop diuretic like furosemide to manage fluid overload, and vancomycin comes along, kidney stress shows up quickly. Even medicines like NSAIDs (ibuprofen, naproxen) sneak into the picture, gnawing away at kidney function without much warning. We don’t always think about over-the-counter painkillers doing harm, but stacked on top of vancomycin, the risk starts to add up.

Less Obvious Pitfalls

Certain anesthetics and muscle relaxants can trigger rare but serious reactions if vancomycin is running through the body, particularly in an operating room setting. Rapid infusion speeds up the risk of “Red Man Syndrome,” causing the skin to flush bright red and severe itching. It helps to slow down the drip rate, but sometimes multiple drugs in a surgery setting make this reaction more likely.

Lab Monitoring and Vigilance

Tracking vancomycin levels in blood isn’t just busywork. The difference between a helpful dose and a kidney-busting dose can be tiny. Blood work, especially trough levels drawn before the next dose, gives real-time feedback. I’ve seen healthcare teams adjust the dose due to a single lab result, saving the kidneys from serious harm. Regular monitoring helps spot problems before they turn critical, and using local antibiogram data can show when vancomycin might not even be needed, protecting patients from unnecessary exposure.

Addressing the Risks

The pharmacy team’s role in checking for medication interactions can’t be overstated. A thorough medication review before starting vancomycin cuts down on surprises. Education matters, both for healthcare workers and patients. Letting people know to avoid extra ibuprofen or naproxen while on vancomycin turns out to be straightforward advice that protects kidney function in the real world.

Antibiotic stewardship programs offer an extra safety net. These programs review prescriptions, making sure vancomycin gets used only when no other option will do. This helps limit unnecessary risk and keeps the drug working for those who truly need it.

Putting Patients First

Keeping track of possible interactions with vancomycin boils down to teamwork. Each member of the care team plays a part in catching risks and putting clear communication at the center. Patients deal with enough when facing tough infections; the system’s job is to cut out extra harm wherever possible. Choosing the safest path isn’t just about following a checklist, it’s about treating people with attention and respect—just as we’d want for our own family.

Vancomycin Hydrochloride
Names
Preferred IUPAC name (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxane-2-carbaldehyde hydrochloride
Other names Vancocin
Vancocin HCl
Vancomycin HCl
Vancoled
Lyphocin
Pronunciation /væŋˈkoʊ.maɪ.sɪn haɪˌdrɒˈklɔː.raɪd/
Identifiers
CAS Number 1404-93-9
Beilstein Reference 1364704
ChEBI CHEBI:9454
ChEMBL CHEMBL1201197
ChemSpider 20534930
DrugBank DB00512
ECHA InfoCard 03b5af0d-9694-4f45-bcce-0c074c1687b7
EC Number EC 4.2.2.19
Gmelin Reference 1265177
KEGG D08211
MeSH D014630
PubChem CID 14969
RTECS number YD0475000
UNII 6T5BBZ55ZJ
UN number UN2811
CompTox Dashboard (EPA) urn:ctfdashboard:DTXSID3023173
Properties
Chemical formula C66H76Cl2N9O24·HCl
Molar mass 1485.71 g/mol
Appearance White to off-white crystalline powder
Odor Odorless
Density 0.8 g/cm3
Solubility in water Freely soluble in water
log P -3.1
Acidity (pKa) 2.18
Basicity (pKb) 7.75
Dipole moment 8.77 D
Pharmacology
ATC code J01XA01
Hazards
Main hazards May cause allergy or asthma symptoms or breathing difficulties if inhaled; may cause an allergic skin reaction
GHS labelling GHS labelling: Not a hazardous substance or mixture according to the Globally Harmonized System (GHS)
Pictograms GHS05,GHS07
Hazard statements H315: Causes skin irritation. H319: Causes serious eye irritation. H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335: May cause respiratory irritation.
Precautionary statements Do not breathe dust or mist. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. Use only with adequate ventilation. Keep container tightly closed.
Lethal dose or concentration LD50 mouse (IV): 319 mg/kg
LD50 (median dose) > 5000 mg/kg (Rat, oral)
NIOSH RT8745000
PEL (Permissible) PEL (Permissible): Not established
REL (Recommended) 0.05 mg/m³
IDLH (Immediate danger) No IDLH established
Related compounds
Related compounds Vancomycin
Teicoplanin
Oritavancin
Dalbavancin
Telavancin