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Product Name: Triclabendazole
Chemical Name: 6-Chloro-2-methylthio-1H-benzimidazole-5-yl N-(phenylsulfonyl)carbamate
CAS Number: 68786-66-3
Intended Use: Veterinary anthelmintic, used for the treatment of fascioliasis primarily in livestock and sometimes in humans
Manufacturer/Supplier: Company name, address, emergency phone number, email for contact
Classification: Not classifiable as hazardous by GHS criteria; may cause mild skin and eye irritation
Signal Word: None expected for typical laboratory or farm use
Hazard Statements: May irritate skin, eyes, and respiratory tract; avoid prolonged or repeated exposure in non-ventilated areas
Pictograms: No pictogram required for non-industrial quantities; larger quantities may require health hazard symbol
Precautionary Statements: Wear gloves, wash hands after handling, avoid generation of dust, use local ventilation for bulk handling
Chemical Substance: Triclabendazole
Purity: 98–100% active ingredient typical for commercial product; remainder consists of process impurities
Other Components: None indicated for pure substance; formulations may contain carriers or diluents
Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Thoroughly wash skin with soap and water, remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes, remove contacts if present and easy, continue rinsing, seek medical attention in case of irritation
Ingestion: Rinse mouth, seek immediate medical advice, do not induce vomiting unless directed by medical personnel
Suitable Extinguishing Media: Use carbon dioxide (CO2), dry powder, foam, or water spray
Unsuitable Media: Avoid high-pressure water jets that can spread dust
Fire Hazards: May produce irritating or toxic fumes (nitrogen oxides, sulfur oxides, hydrochloric acid, carbon oxides) during combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Precautions: Cool containers exposed to fire with water spray until well after fire is out
Personal Precautions: Wear appropriate PPE, avoid creating dust, ventilate area
Environmental Precautions: Prevent entry into drains, surface water, or soil
Cleanup Methods: Collect spilled material by dry sweeping, shovel into suitable containers, avoid generating dust, wash contaminated area with water, dispose in accordance with local regulations
Handling: Use local ventilation when transferring large or dusty amounts, wear gloves and protective eyewear, avoid inhaling dust, do not eat, drink, or smoke during use
Storage: Store in tightly closed containers away from sunlight, moisture, and extreme temperature; keep in designated chemical storage area; separate from foodstuffs and animal feeds
Special Instructions: Keep away from children and unauthorized personnel
Engineering Controls: Use local exhaust ventilation where (potential) dust exposure exists
Respiratory Protection: For industrial use, NIOSH-approved dust mask or respirator (P1 or P2) recommended during handling of powder or bulk material
Skin Protection: Wear chemical-resistant gloves, lab coat or coveralls
Eye Protection: Chemical splash goggles or face shield
Hygiene Measures: Wash hands and face after use; remove and wash contaminated clothing before reuse
Exposure Limits: No established occupational exposure limit; minimize workplace exposure as a general precaution
Appearance: Off-white to pale yellow crystalline powder
Odor: Odorless or slight odor
Molecular Weight: 359.82 g/mol
Melting Point: About 177–180°C
Boiling Point: Not applicable (decomposes)
Solubility: Practically insoluble in water; soluble in dichloromethane, slightly soluble in acetone and ethanol
Density: 1.47–1.50 g/cm3 (estimated)
Vapor Pressure: Negligible
Partition Coefficient (log Pow): 4.26 (at 25°C)
Chemical Stability: Stable under normal use and storage conditions
Reactivity: Not reactive under recommended handling
Incompatible Materials: Strong acids, strong bases, strong oxidizers
Hazardous Reactions: None expected under conditions of normal use; overheating may release hazardous fumes
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon monoxide, carbon dioxide
Acute Toxicity: Oral LD50 in rats >2000 mg/kg
Skin Irritation: May cause mild, reversible irritation with prolonged or repeated contact
Eye Irritation: Possible mild irritant
Chronic Exposure: No evidence of carcinogenicity, mutagenicity, or teratogenicity found in standard animal studies
Sensitization: No data indicating skin sensitization
Other Risks: Large, repeated oral doses could affect liver or kidneys in animal studies
Ecotoxicity: Toxic to aquatic organisms, especially fish and daphnia; may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Moderately persistent in soil and water; slow degradation
Bioaccumulation: Has potential to bioaccumulate (log Pow >4)
Mobility in Soil: Low mobility due to poor water solubility
Other Adverse Effects: Careless disposal may affect non-target species in water and field systems
Disposal Methods: Incinerate in designated chemical incineration facility; landfilling only as last resort, follow local and national waste disposal regulations
Container Instructions: Empty containers should be triple-rinsed and disposed of properly or returned for reuse by supplier
Prevent Contamination: Do not allow product or rinsate to enter drains, waterways, or soil
UN Number: Not regulated
Proper Shipping Name: Not regulated as a dangerous good
Transport Hazard Class: N/A
Packing Group: N/A
Special Precautions: Ship in original or correctly labeled secondary containers, protect from damage during transit
Global Inventories: Approved for veterinary use in many countries, check local registration
Hazard Category: Not classified as hazardous chemical according to current GHS and OSHA criteria
Labeling: Safety phrases and precautionary statements recommended; some jurisdictions may require specific labeling
Other Regulations: Veterinary medicines legislation, pesticide or environmental regulations may apply; consult local authorities for compliance
