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Product Name: Triamcinolone Acetate
Chemical Name: 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide
Molecular Formula: C24H31FO6
Chemical Family: Corticosteroid
CAS Number: 76-25-5
Intended Use: Pharmaceutical ingredient used for anti-inflammatory and immunosuppressive purposes
Manufacturer’s Contact: Emergency phone numbers and addresses provided by supplier documentation
Synonyms: Triamcinolone-16,17-acetonide acetate, Aristocort acetate, Kenalog
Recommended Use: Ingredient in medications, topical ointments, and injectable formulations
Classification: Not classified as hazardous according to OSHA criteria for pharmaceuticals, but may cause adverse health effects through inhalation, ingestion, or skin contact
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Health Effects: Prolonged exposure can impact hormone balance, may cause Cushingoid symptoms, immunosuppression, and delayed wound healing
Carcinogenicity: No classification by NTP, IARC, or OSHA; long-term safety in humans requires clinical monitoring
Signal Word: Warning
Hazard Statements: May cause skin, eye, and respiratory irritation; absorption may produce systemic effects.
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, wear protective gear.
Ingredient: Triamcinolone Acetate
Concentration: 97-100%
Impurities: Residual solvents and minor related corticosteroid derivatives in trace amounts
Additives: None present
CAS Number: 76-25-5
Inhalation: Remove from exposure area to fresh air. Seek medical attention if symptoms like shortness of breath, coughing, or dizziness persist.
Skin Contact: Immediately wash exposed skin with plenty of soap and water. Remove contaminated clothing.
Eye Contact: Rinse cautiously with water for at least 15 minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention if irritation develops.
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting. Obtain medical advice if symptoms such as nausea, vomiting, or abdominal pain occur.
Advice for Medical Personnel: Treat symptomatically and supportively. Monitor for signs of corticosteroid excess.
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray to cool fire-exposed containers
Unsuitable Extinguishing Media: Direct water jet may spread material
Special Hazards: Fine powder may form explosive dust-air mixtures. Thermal decomposition may produce irritating fumes, carbon oxides, and hydrogen fluoride.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Advice: Remove containers from fire area if it can be done safely. Avoid inhalation of combustion products.
Personal Precautions: Wear appropriate protective clothing, gloves, eye and respiratory protection to prevent skin and eye contact and inhalation of dust
Methods for Cleaning Up: Avoid dry sweeping. Dampen with water or use HEPA-filtered vacuum. Place material in a closed, labeled waste container
Environmental Precautions: Prevent entry into drains or waterways. Notify authorities if large releases occur
Decontamination: Clean spill area with soap and water after removal
Handling: Minimize dust generation and accumulation. Use in well-ventilated areas. Avoid contact with skin, eyes, and clothing. Practice good industrial hygiene.
Storage: Store in original tightly closed containers at controlled room temperature, away from incompatible substances including strong oxidizers. Protect from light, moisture, and physical damage. Keep out of reach of unauthorized personnel.
Special Sensitivity: Material is light sensitive and should be protected from direct sunlight
Incompatibilities: Avoid strong acids, bases, and oxidizing agents
Exposure Limits: No Occupational Exposure Limits established for Triamcinolone Acetate, but minimize exposure by pharmaceutical workplace practices
Engineering Controls: Handle in closed systems or use local exhaust ventilation to control dust
Personal Protective Equipment: Appropriately fitted NIOSH-approved respirators for dust, chemical-resistant gloves, safety goggles for eye protection, and lab coat or apron
Hygiene Measures: Wash hands thoroughly after handling and before eating, drinking, or smoking. Remove contaminated clothing and wash before reuse
Appearance: White to off-white, crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not applicable
Melting Point/Freezing Point: 274-278°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not determined
Evaporation Rate: Not determined
Flammability: Not highly flammable but can form combustible dust clouds
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Solubility: Insoluble in water; soluble in organic solvents like ethanol, acetone, and chloroform
Partition Coefficient (log Kow): Approximately 2.2
Auto-Ignition Temperature: Not available
Decomposition Temperature: Not available
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and handling conditions
Hazardous Reactions: No known dangerous reactions under normal use
Incompatible Materials: Strong oxidizers, strong acids or bases
Conditions to Avoid: Exposure to excessive heat, open flames, and sources of ignition
Hazardous Decomposition Products: May produce toxic gases such as carbon oxides and hydrogen fluoride on decomposition
Acute Toxicity: Data limited, but not acutely toxic in prescribed pharmaceutical doses; ingestion of large amounts may cause symptoms of corticosteroid overdose
Skin Corrosion/Irritation: Mild irritation may occur with prolonged skin contact
Serious Eye Damage/Irritation: Direct contact may cause irritation
Respiratory Sensitization: Potential for respiratory tract irritation
Skin Sensitization: Not established, though allergic reactions possible
Chronic Effects: Repeated exposure may suppress immune function, cause hormonal imbalance, osteoporosis, glucose intolerance, delayed wound healing, and Cushing’s syndrome
Mutagenicity/Carcinogenicity: No conclusive data on mutagenic or carcinogenic potential in humans
Ecotoxicity: Risk to aquatic life considered low at environmental concentrations, but large spills may harm aquatic organisms
Persistence and Degradability: Compound may persist under certain environmental conditions, breaks down slowly
Bioaccumulation: Potential for bioaccumulation exists, though environmental concentrations from pharmaceutical use are low
Mobility in Soil: Low water solubility limits movement; will bind to soil and sediments
Other Adverse Effects: Available ecotoxicological data indicate minimal risk under ordinary disposal, but proper containment and disposal essential to minimize broader impacts
Waste Disposal Methods: Dispose of according to local, state, and federal regulations as pharmaceutical waste. Avoid release to environment.
Contaminated Packaging: Dispose of containers as hazardous waste.
Special Precautions: Do not landfill large volumes; incineration preferred method by licensed waste vendor
Reuse/Recycle: Not recommended; dedicated waste stream essential for pharmaceuticals
UN Number: Not regulated as a hazardous material for transport under ADR, DOT, IATA, or IMDG
Proper Shipping Name: Not designated a hazardous substance during transport
Packing Group: Not assigned
Transport Hazard Class: Not classified
Special Precautions: Secure packaging to avoid physical damage, dust generation, and spillage
US Regulations: Not classified as hazardous under OSHA Hazard Communication Standard. Subject to prescription drug regulations and DEA pharmaceutical guidelines.
International Regulations: Not scheduled for environmental hazard criteria in EU, Japan, or Australia, but regulated for pharmaceutical use
WHMIS (Canada): Not controlled
Other Information: Users should comply with local and country-specific legislation regarding pharmaceutical product handling, workplace exposure, environmental release, and disposal.
SARA Title III: Not reportable
California Proposition 65: Not listed
TSCA Status: Exempt as a pharmaceutical intermediate
Labelling Requirements: Clear identification as prescription pharmaceutical; not for general consumer or over-the-counter use
