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Product Name: Tolphenidone
Chemical Family: Pyridone derivative
Synonyms: 2-(Dimethylamino)-5,6-dimethyl-4-(3-pyridyl)pyridone
CAS Number: 27589-22-0
Manufacturer: [Company information required]
Intended Use: Pharmaceutical research, chemical synthesis
Contact Information: [Company address and emergency phone number]
GHS Classification: Skin irritation (Category 2), Eye irritation (Category 2A), Specific target organ toxicity – single exposure (Category 3)
Signal Word: Warning
Hazard Statements: Causes skin irritation, causes serious eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust, wear protective gloves and eye protection, wash exposed skin, use only outdoors or in a well-ventilated area
OSHA Hazards: Irritant
Chemical Name: Tolphenidone
Concentration: ≥98% by weight
Impurities: Trace solvents and related impurities ≤2%
Molecular Formula: C14H17N3O
Molecular Weight: 243.31 g/mol
Eye Contact: Rinse eyes with water for at least 15 minutes, seek medical attention if irritation develops.
Skin Contact: Wash area with plenty of water and mild soap, remove contaminated clothing, seek medical attention if symptoms persist.
Inhalation: Move person to fresh air, monitor for respiratory symptoms, seek medical attention if discomfort continues.
Ingestion: Rinse mouth with water, never induce vomiting, seek immediate medical advice.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol-resistant foam
Specific Hazards: Combustion releases toxic fumes such as nitrogen oxides, carbon monoxide, carbon dioxide
Advice for Firefighters: Wear self-contained breathing apparatus, full protective equipment, avoid smoke inhalation, contain run-off to prevent environmental injury
Personal Precautions: Wear recommended personal protective equipment, prevent skin and eye exposure, do not breathe dust
Environmental Precautions: Prevent entry into drains, surface and ground water
Methods for Clean-Up: Use inert absorbent material, place in suitable waste container, ventilate area, complete a thorough decontamination of affected surfaces
Handling: Use in a chemical fume hood, avoid dust generation, maintain proper hygiene, store incompatible materials separately
Storage: Keep container tightly closed in dry, well-ventilated location, store away from incompatible chemicals such as strong oxidizers, acids, protect from direct sunlight and temperatures above 30°C
Occupational Exposure Limits: No specific occupational exposure limit established
Engineering Controls: Use chemical fume hood, ensure eye wash stations and safety showers remain accessible
Personal Protective Equipment: Chemical-resistant gloves, safety glasses with side-shields, laboratory coat, if dust present use NIOSH-approved respirator
Appearance: Off-white to pale yellow crystalline powder
Odor: Faint organic
Odor Threshold: Not determined
pH: Not applicable (insoluble in water)
Melting Point / Freezing Point: 113-117°C
Boiling Point: Not determined
Flash Point: Not determined
Evaporation Rate: Not determined
Flammability: May be combustible
Solubility in Water: Slightly soluble
Solubility (Other): Soluble in acetone, ethanol, DMSO
Partition Coefficient (n-octanol/water): Not determined
Vapor Pressure: Not determined
Vapor Density: Not determined
Density: Approx. 1.16 g/cm³
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: No hazardous reactions expected with normal use
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide
Conditions to Avoid: Extreme heat, incompatible chemicals, sources of ignition
Acute Toxicity: Data not available; may cause harm if swallowed or inhaled
Skin Corrosion/Irritation: May cause skin irritation
Serious Eye Damage/Irritation: May cause eye irritation
Respiratory Sensitization: May cause respiratory tract irritation
Skin Sensitization: Not expected under normal use
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: Data insufficient for assessment
STOT (Specific Target Organ Toxicity) - Single Exposure: May cause drowsiness or dizziness
Chronic Toxicity: Information not available
Aquatic Toxicity: No comprehensive data available
Persistence and Degradability: Limited data on environmental degradation
Bioaccumulation Potential: No relevant data, monitoring advised
Mobility in Soil: Expected low mobility due to low water solubility
Other Adverse Effects: Prevent chemical from entering water bodies, wastewater, or soil uncontained
Product Disposal: Dispose as hazardous chemical waste in accordance with local, state, and federal regulations
Contaminated Packaging: Rinse with suitable solvent, dispose as hazardous waste
Recommended Disposal Methods: Incineration in approved facilities, avoid disposal to landfill or drain
UN Number: Not classified as dangerous for transport
Proper Shipping Name: Not regulated
Transport Hazard Class: Not indicated
Packing Group: Not assigned
Marine Pollutant: Not classified
Special Precautions: Prevent breakage, secure packaging, transport in upright containers
US TSCA Status: Not listed
EU REACH Status: Not registered
SARA Title III (Sections 302/311/312/313): Not reportable
California Proposition 65: Not listed
Inventory Listings: Check national requirements
Label Elements: Necessary to comply with chemical labeling regulations
