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Product Name: Tolfenamic Acid
Chemical Formula: C14H12ClNO2
CAS Number: 13710-19-5
Usage: Used for the treatment of inflammation and pain in veterinary medicine, mainly in cattle and horses.
Manufacturer Details: See packaging for specific production source.
Contact Information: Emergency phone numbers and direct lines attached to product container from the distributor.
Other Identifiers: Often labeled under non-steroidal anti-inflammatory drugs (NSAIDs).
Classification: Not classified as a hazardous substance according to GHS standards for general workplace exposure.
Physical Hazards: Tolfenamic Acid is a white or slightly off-white powder, not highly flammable but fine dust may form explosive mixtures in air under particular conditions.
Health Hazards: Inhalation may cause mild respiratory irritation; ingestion can irritate gastrointestinal tract; skin and eye contact can trigger irritation and allergic reactions.
Environmental Hazards: Harmful to aquatic organisms and may cause long-term adverse effects in the aquatic environment.
Signal Word: Warning
Precautionary Statements: Use only in well-ventilated areas, avoid release into the environment, wash hands after handling.
Chemical Name: Tolfenamic Acid
CAS Number: 13710-19-5
Concentration: 99% or higher
Impurities: Trace organic solvents and related degradation products below the threshold of hazardous concern.
Other Components: No additives, formulated to pharmaceutical standard.
Inhalation: Move person to fresh air; provide oxygen if breathing is difficult.
Skin Contact: Wash thoroughly with soap and water; take off contaminated clothing; seek medical attention if irritation develops.
Eye Contact: Rinse cautiously with water for at least 15 minutes, opening eyelids widely; seek medical advice if irritation persists.
Ingestion: Rinse mouth; do not induce vomiting; seek medical attention.
Most Important Symptoms: Respiratory trouble, persistent redness or rash, or gastrointestinal discomfort.
Special Precautions: Always share packaging or labeling with medical staff.
Suitable Extinguishing Media: Use foam, dry chemical powder, carbon dioxide, or water spray.
Unsuitable Media: Avoid direct high-pressure water jets.
Specific Hazards: Can produce toxic gases on combustion, such as nitrogen oxides, hydrogen chloride, and carbon oxides.
Special Protective Equipment: Firefighters need self-contained breathing apparatus and protective clothing.
Additional Recommendations: Cool containers exposed to flames with water spray; prevent runoff from entering waterways.
Personal Precautions: Wear suitable protective equipment; avoid inhalation, skin, and eye contact.
Emergency Procedures: Ventilate area, evacuate unnecessary personnel, and avoid dust formation.
Clean-up Methods: Scoop up into properly labeled containers using non-sparking tools; sweep and place in waste disposal bag.
Environmental Precautions: Prevent further leakage or spillage; avoid contamination of watercourses and drains.
Decontamination: Wash area thoroughly with water after removal of material.
Safe Handling: Handle in accordance with good industrial hygiene and safety protocols; avoid dust generation and inhalation; do not eat, drink, or smoke while handling.
Technical Measures: Use with adequate ventilation; install local exhaust as needed.
Safe Storage: Store tightly closed in a cool, dry place, away from direct sunlight and incompatible substances.
Conditions to Avoid: Excessive heat, moisture, oxidizing agents, and sources of ignition.
Incompatible Materials: Strong oxidants, acids, and reducing agents.
Other Recommendations: Keep out of reach of children and unauthorized persons.
Occupational Exposure Limits: No established TLV or PEL for Tolfenamic Acid; follow general workplace exposure standards.
Engineering Controls: Local exhaust ventilation, safety showers, and eye washing facilities where dust may be generated.
Personal Protective Equipment: NIOSH-approved respirator if dust is formed; chemical-resistant gloves and protective clothing; safety goggles or face shield for eye protection.
Environmental Exposure Controls: Prevent product from entering drains and watercourses.
Appearance: Fine, white to off-white crystalline powder
Odor: Odorless
pH: 6.5–7.5 (in suspension)
Melting Point: Around 212°C
Boiling Point: Decomposes on heating
Flash Point: Not flammable at standard temperatures
Solubility: Poorly soluble in water; soluble in organic solvents such as acetone and methanol
Vapor Pressure: Negligible at ambient conditions
Density: 1.33 g/cm³
Partition Coefficient (Log Pow): About 4.67
Other Properties: Stable in dry air, sensitive to strong oxidizing conditions.
Chemical Stability: Chemically stable under recommended storage conditions.
Conditions to Avoid: Elevated temperatures, moisture, acidic or basic conditions, strong light, and incompatible chemicals.
Materials to Avoid: Oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products: Under fire or high heat, decomposition yields gases like nitrogen oxides, hydrogen chloride, and carbon oxides.
Polymerization: No hazardous polymerization expected.
Acute Toxicity: Oral LD50 (rat): 700 mg/kg; Inhalation LC50 (rat): not determined.
Skin Corrosion/Irritation: Causes mild skin irritation in some individuals.
Serious Eye Damage/Irritation: Causes eye irritation.
Respiratory or Skin Sensitization: May cause allergic reactions after prolonged or repeated exposure.
Germ Cell Mutagenicity: Not classified; animal data suggest low mutagenic risk.
Carcinogenicity: No evidence of carcinogenic potential.
Reproductive Toxicity: Studies indicate low risk but direct contact during pregnancy best avoided.
Symptoms of Overexposure: Headache, nausea, vomiting, dermatitis, respiratory discomfort.
Medical Conditions Aggravated by Exposure: Pre-existing allergies, skin disorders, and respiratory illnesses.
Ecotoxicity: Harmful to aquatic life; LC50 (fish, 96 h): 45 mg/L
Persistence and Degradability: Not readily biodegradable; may persist in water and soil.
Bioaccumulative Potential: High log Pow suggests risk for bioaccumulation.
Mobility in Soil: Moderately mobile; potential to leach into groundwater if improperly disposed.
Other Adverse Effects: Long-term effects possible due to stability and persistence.
Waste Treatment Methods: Incinerate in a properly equipped facility; do not flush to drain or sewer.
Disposal of Packaging: Triple rinse containers before disposal; manage as hazardous waste according to local, state, and federal regulations.
Additional Recommendations: Consult a licensed professional waste disposal service for proper handling according to all regulations.
Special Precautions: Do not reuse empty containers for other purposes.
DOT (US): Not regulated as dangerous goods.
IMDG: Not regulated as maritime hazardous material.
ICAO/IATA: Not regulated for air transport.
Transport Precautions: Avoid excessive heat; keep containers tightly closed and upright during transportation.
UN Number: Not assigned.
Special Transport Notes: Always secure containers to prevent movement or spillage.
US TSCA: Listed
EU EINECS: Listed
WHMIS Classification (Canada): Not controlled
SARA Title III: Not listed as an extremely hazardous chemical.
California Proposition 65: Not listed
Other Regulatory Info: Requires a prescription for veterinary use; usage, disposal, and handling must follow strict guidelines in territory of sale or manufacture; always refer to local and international chemical regulations for compliance details.
