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Product Name: Tioconazole
Chemical Name: 1-[2-[(2-Chllorothiophen-2-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
Synonyms: Trosyd; Gyno-Trosyd
CAS Number: 65899-73-2
Recommended Use: Antifungal agent for pharmaceutical use
Supplier Details: Details of manufacturer and distributor can be found on the package or request.
Emergency Telephone: Local emergency services or poison control center
Classification: May cause skin irritation, possible eye irritation, mild respiratory irritation on exposure to dust
GHS Label Elements: Warning symbol for health hazard, exclamation mark
Hazard Statements: Suspected of damaging fertility; may cause respiratory tract and skin irritation; harmful if swallowed
Precautionary Statements: Avoid breathing dust, avoid eye/skin contact, wear personal protective gear, wash thoroughly after handling
Routes of Exposure: Eye contact, skin contact, inhalation, ingestion
Other Hazards: Not classified as flammable; dust formation might risk explosion in poorly ventilated areas
Chemical Name: Tioconazole
CAS Number: 65899-73-2
Purity: ≥98% (may include small traces of related substances)
Other Components: Pharmaceutical formulations may include excipients and stabilizing agents which do not alter the core safety profile
Inhalation: Remove person to fresh air, support breathing as needed; seek medical attention for symptoms
Skin Contact: Take off contaminated clothing, rinse skin thoroughly with water; medical assessment for persistent redness/irritation
Eye Contact: Rinse eyes with water for at least 15 minutes, lift eyelids occasionally; medical evaluation in case of ongoing discomfort
Ingestion: Rinse mouth; do not induce vomiting unless instructed by poison control; seek immediate medical attention
Note to Physicians: Deliver supportive care and symptomatic treatment, watch for symptoms involving respiratory function and allergic response
Suitable Extinguishing Media: Use water spray, foam, dry chemical or carbon dioxide
Specific Hazards: May release hazardous fumes such as hydrogen chloride, nitrogen oxides, sulfur oxides, and other organics on burning
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, chemical-resistant suit, boots, and gloves
Advice for Firefighters: Control runoff water to prevent environmental contamination; move containers from area if possible and safe to do so; avoid inhalation of combustion gases
Personal Precautions: Evacuate area, ventilate space, avoid dust generation, use personal protective equipment (mask, goggles, gloves, proper clothing)
Environmental Precautions: Prevent product from entering waterways, sewers, or soil; contain spill with absorbent material
Methods for Clean-up: Sweep up without dispersing dust, collect in appropriate labeled container for waste disposal, wash spill site with copious water
Notification Procedures: Report significant release to local environmental authorities as required
Precautions for Safe Handling: Process in areas with adequate ventilation, avoid formation and inhalation of dust, wash hands thoroughly after touching, avoid eating, drinking, or smoking during use
Storage Conditions: Keep tightly closed in a cool, dry, and well-ventilated place; protect from direct sunlight, strong oxidizers, and incompatible materials; keep container out of reach of children and unauthorized personnel
Incompatible Materials: Strong oxidizers, acids, and alkalis; store separately from food and drink
Handling Advice: Implement spill containment procedures in event of accidental release in storage areas
Exposure Limits: No specific occupational exposure limits established; general threshold for nuisance dust: 10 mg/m³ (inhalable), 3 mg/m³ (respirable)
Engineering Controls: Use local exhaust ventilation or fume hood; handle only in well-ventilated environments
Personal Protective Equipment: Chemical-resistant gloves, protective goggles, lab coat, dust mask or respirator for bulk handling
General Hygiene: Remove contaminated clothing, launder before reuse, keep away from food, avoid contact with skin, eyes, and clothing
Appearance: White to off-white crystalline powder
Odor: Odorless or faintly medicinal
Melting Point: 82-86°C
Boiling Point: Not applicable (decomposes on heating)
Solubility: Practically insoluble in water, soluble in chloroform, ethanol, methanol, and other organic solvents
pH: Not applicable (insoluble in water)
Vapor Pressure: Very low at ambient temperature
Partition Coefficient (log P): About 3.9 (octanol/water)
Flammability: Not highly flammable under typical storage conditions
Other Data: Molecular weight: 387.64 g/mol; stable under recommended storage conditions
Chemical Stability: Stable under normal conditions, sensitive to strong oxidizers, acids, and bases
Reactivity: Low reactivity profile; avoid excessive heat and incompatible substances
Possible Hazardous Reactions: None under standard handling; decomposition may generate irritant and/or toxic gases at high temperatures
Incompatible Materials: Strong oxidants, strong acids, strong bases, sources of ignition or open flame
Conditions to Avoid: Moisture, sunlight, heat, contact with incompatible substances
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide
Acute Toxicity: Oral LD50 in rodents >300 mg/kg (low acute toxicity via oral route)
Skin Irritation: May cause mild irritation on prolonged exposure
Eye Irritation: May induce mild reversible irritation
Sensitization: Sensitization reactions rarely documented in users
Chronic Exposure: Rare reports of systemic effects; reproductive toxicity not confirmed in humans, animal studies show possible risk
Carcinogenicity: No established data on carcinogenicity; not listed by IARC, NTP, or OSHA
Target Organs: None conclusively identified in therapeutic use; accidental exposure to dust may irritate respiratory system
Ecotoxicity: Possible moderate hazard to aquatic organisms; chronic toxicity data not well established
Persistence and Degradability: Expected to be poorly biodegradable; persistent in surface water and soil
Bioaccumulative Potential: Log P value suggests potential to bioaccumulate in aquatic species
Mobility in Soil: Poor solubility may limit migration; risk to groundwater low
Other Hazards: May contribute to antifungal resistance in aquatic microbial populations
Waste Disposal Methods: Dispose of unused product, contaminated packaging, and spill residue through a licensed waste disposal contractor; incineration is preferred for bulk material
Precautions: Do not allow product to enter drains, sewers, watercourses, or soil; follow local regulations for hazardous waste
Contaminated Packaging: Rinse empty containers before recycling or disposal; follow label or local authority guidance
UN Number: Not classified as dangerous for transport under ADR, IMDG, IATA
Proper Shipping Name: Tioconazole or pharmaceutical preparation (as appropriate to packaging)
Hazard Class: Not regulated
Packing Group: Not applicable
Transport Precautions: Store upright, secure packages; avoid exposure to sunlight and moisture during transit
Special Provisions: None; not subject to transport restrictions for hazardous materials
GHS Classification: Irritant
TSCA: Not listed as controlled substance
REACH Status (EU): Not subject to Annex XVII restrictions; check pre-registration if importing to the EU
SARA Title III: Not subject to reporting requirements
Other Regulations: Pharmaceutical ingredient regulated under medicinal product guidelines; workplace exposure and reporting governed by local occupational health and environmental agencies
