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Product Name: Thiamphenicol
Chemical Name: (R)-2,2-dichloro-N-[1,3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
CAS Number: 15318-45-3
Recommended Use: Antibiotic agent, veterinary and sometimes human medicine
Manufacturer/Supplier: Contact the local distributor for specific details
Emergency Phone: Refer to site-specific emergency numbers
GHS Classification: Eye irritation (Category 2A); Skin irritation (Category 2); Respiratory tract irritation
Signal Word: Warning
Hazard Statements: Causes skin irritation; Causes serious eye irritation; May cause respiratory irritation
Pictogram: Exclamation mark
Precautionary Statements: Avoid breathing dust; Wash hands thoroughly after handling; Use in a well-ventilated area; Wear protective gloves, eye protection, and face protection
Health Effects: Irritates eyes, skin, and respiratory tract; Prolonged exposure may lead to damage in bone marrow or blood changes
Chemical Identity: Thiamphenicol
CAS Number: 15318-45-3
Concentration: Pure substance or available as formulated product in combination with inactive ingredients
Inhalation: Move the exposed person to fresh air; Seek medical attention if symptoms persist; Provide oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing; Rinse skin with water and soap for at least 15 minutes; Seek medical help if irritation appears
Eye Contact: Rinse with plenty of water for several minutes, lifting eyelids; Remove contact lenses if present and easy to do; Get medical assistance if irritation continues
Ingestion: Rinse mouth with water; Do not induce vomiting unless directed by medical personnel; Seek medical attention immediately
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide or alcohol-resistant foam
Unsuitable Media: Do not use strong water jets which may spread the chemical
Fire Hazards: Decomposition releases hazardous gases including chlorine, nitrogen oxides, and sulfur oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Firefighting Instructions: Fight fire from a safe distance; Prevent fire water from entering drains or watercourses
Personal Precautions: Wear appropriate protective equipment including gloves, protective clothing, goggles, and a dust mask
Environmental Precautions: Prevent further leakage or spillage if safe to do so; Avoid release into the environment; Contain spill to avoid contamination of soil and waterways
Cleanup Methods: Sweep up and place in suitable closed containers for disposal; Ventilate area; Clean affected surfaces with soap and water; Dispose of waste in accordance with local regulations
Handling: Use personal protective equipment; Work in well-ventilated areas; Avoid inhalation, ingestion, and contact with skin or eyes; Practice good hygiene after use
Storage: Store tightly closed in a cool, dry, well-ventilated place; Keep away from incompatible materials such as strong oxidizers; Protect from moisture; Nestle containers away from heat or open flames; Prevent static discharge during handling
Exposure Limits: No established OSHA or ACGIH exposure limits; Follow good laboratory and industrial hygiene practice
Engineering Controls: Use local exhaust ventilation to control airborne levels; Install safety showers and eye wash stations
Personal Protective Equipment: Respiratory protection if dust is generated; Chemical-resistant gloves; Safety goggles or face shield; Protective laboratory clothing or coveralls
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling; Remove and wash contaminated clothing before reuse
Appearance: White or almost white crystalline powder
Odor: Odorless
Molecular Formula: C12H15Cl2NO5S
Molecular Weight: 356.23 g/mol
Melting Point: 153-157°C
Boiling Point: Not applicable (decomposes)
Solubility: Slightly soluble in water; freely soluble in methanol and ethanol
pH: Neutral solution
Vapor Pressure: Not available
Partition Coefficient (log Kow): Not available
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: No hazardous reactions under recommended storage and use conditions
Conditions to Avoid: Exposure to excessive heat, moisture, and strong oxidizing agents
Incompatible Materials: Strong oxidizers, acids, bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, hydrogen chloride gas
Polymerization: Will not occur
Acute Toxicity: LD50 Oral (rat): 2200 mg/kg; LD50 Dermal: Data unavailable
Skin Irritation: Causes skin irritation with redness and dryness
Eye Irritation: May irritate eyes resulting in redness, tearing, and pain
Respiratory Irritation: Dust inhalation may cause coughing, sore throat, and respiratory discomfort
Chronic Effects: Prolonged exposure can cause bone marrow suppression, possible blood disorders including aplastic anemia
Carcinogenicity: Thiamphenicol is not classified as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: Some studies suggest potential mutagenic effects
Reproductive Toxicity: Animal studies point to possible effects on fertility and fetal development with high dosages
Ecotoxicity: Harmful to aquatic environments; May be toxic to aquatic organisms with long-lasting effects
Persistence and Degradability: Not readily biodegradable; Persists in soil and water
Bioaccumulative Potential: Low potential for bioaccumulation has been reported
Mobility in Soil: Expected to have medium mobility in soil; Potential for groundwater contamination exists if not handled correctly
Other Adverse Effects: Antibiotic residues in water systems can contribute to antibiotic resistance in bacteria
Waste Disposal Methods: Collect and dispose of in accordance with all applicable local, national, and regional regulations; Do not dispose of in drains or waterways
Contaminated Packaging: Triple rinse containers; Dispose of as hazardous waste
Special Precautions: Handle waste to minimize exposure; Use licensed waste disposal contractors where appropriate
UN Number: Not regulated for transport
Transport Hazard Class: Not classified as a dangerous good
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant under IMDG guidelines
Special Transport Precautions: Prevent release during transport; Ensure containers remain sealed and secure
US TSCA Status: Listed or exempt
EU Regulations: Not subject to classification under Regulation (EC) No. 1272/2008 (CLP); Subject to veterinary medicinal product controls
Other Regulatory Requirements: Restrictions may apply in specific jurisdictions; Compliance with state, national, and international chemical safety laws is a must; Check import/export rules before shipping internationally
