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Product Name: Thiamethoxam
Chemical Name: 3-(2-chloro-1,3-thiazol-5-ylmethyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene(nitro)amine
CAS Number: 153719-23-4
Recommended Use: Insecticide for agricultural crops
Supplier: Chemical manufacturer or distributor details as per label
Contact Information: Emergency telephone numbers, physical address for supplier
Synonyms: Cruiser, Actara, Platinum (formulated products may vary by region and concentration)
GHS Classification: Acute Toxicity (Oral) Category 4, Acute Toxicity (Inhalation) Category 4, Eye Irritation Category 2B, Hazardous to the Aquatic Environment (Acute) Category 1, Hazardous to the Aquatic Environment (Chronic) Category 1
Pictograms: Exclamation mark, Environment
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled, Causes eye irritation, Very toxic to aquatic life with long lasting effects
Precautionary Statements: Avoid breathing dust, Wear protective equipment, Wash thoroughly after handling, Restrict release to the environment, Collect spillage, Dispose of contents/container under local regulations
Potential Health Effects: Symptoms may include irritation of eyes, nose, throat; nausea, dizziness, headache upon exposure; risk of aquatic toxicity from even small releases
Active Ingredient: Thiamethoxam
Chemical Formula: C8H10ClN5O3S
Percentage by Weight: Varies with product formulation, typically 20–35% in commercial formulations
Additional Ingredients: Fillers, carriers, surfactants, and solvents listed in product label or specific supplement (often considered confidential business information but may include kaolin clay, mineral oils, and emulsifiers).
Impurities: Specified by manufacturer, important for those with sensitivity to trace chemicals, but not typically at levels expected to cause additional hazard
Inhalation: Move person to fresh air; seek medical advice if symptoms appear.
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water.
Eye Contact: Rinse eyes with water for several minutes, keep eyelids open, remove contact lenses if present and easy to do, get medical attention for persistent irritation.
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice—carry product label or container.
Note for Physicians: Symptomatic treatment as supportive therapy; no specific antidote known; monitor for respiratory or allergic reactions; consider prolonged observation after significant exposure.
Main Symptoms: Headache, dizziness, nausea, eye irritation, breathing difficulties after very high exposure.
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray (diking helps prevent contaminated runoff).
Unsuitable Extinguishing Media: Direct jet of water on product may spread material.
Specific Hazards: Product can emit toxic fumes of nitrogen oxides, sulfur oxides, chlorine compounds when heated or burned
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Fire/Explosion Hazards: Dusts may form combustible mixtures with air if finely divided; containment recommended
Decomposition Products: Thermal decomposition releases carbon monoxide, carbon dioxide, hydrogen chloride, nitrogen oxides, and sulfur oxides.
Personal Precautions: Avoid breathing dust or vapors; use personal protective equipment recommended in section on exposure control; evacuate unnecessary personnel, ensure adequate ventilation.
Environmental Precautions: Prevent entry into drains, sewers, ditches, and waterways; dangerous to aquatic environments even at low concentrations.
Methods for Cleanup: Sweep or scoop spilled product with as little dust generation as possible; use damp cloth for final cleaning; collect for disposal in labeled container; wash area with water, avoid direct runoff.
Disposal: Adhere to regional regulations on pesticide disposal; avoid contamination of soil and water; collected material must not be reused
Handling: Wear suitable protective clothing, gloves, and eye/face protection; avoid inhaling dust; wash hands and face after use; do not eat, drink, or smoke while handling.
Storage: Store in original container, tightly closed in a cool, dry, well-ventilated area away from incompatible chemicals, food, drink, and animal feed.
Incompatibilities: Strong acids, strong bases, strong oxidizing agents.
Special Storage Instructions: Keep locked up and out of reach of children and unauthorized personnel.
Transfer Procedures: Prevent spills and dust generation; use tools designed for chemical handling.
Occupational Exposure Limits: No specific occupational exposure limit values set for thiamethoxam by OSHA, NIOSH; use general dust limits as a guide.
Engineering Controls: Local exhaust ventilation, process enclosure, or other controls to keep airborne concentrations below recommended levels; safety showers and eyewash stations.
Personal Protection: Chemical resistant gloves (nitrile, neoprene), safety goggles, coveralls or long-sleeved clothing, suitable respiratory protection if dust may be generated.
Hygiene Measures: Wash thoroughly after handling, remove and clean protective equipment and contaminated clothing before reuse, no eating or smoking during use.
Appearance: Off-white to light beige crystalline powder or in granulated form as packaged product.
Odor: Faint, not distinctive
Odor Threshold: Not determined
pH: 5–7 at 1% solution
Melting Point/Range: 139–140°C
Boiling Point/Range: Decomposes before boiling
Flash Point: Not applicable (solid form)
Flammability: May pose a risk if dust is dispersed in air; not highly flammable
Evaporation Rate: Not applicable
Vapor Pressure: 1.6 × 10⁻¹¹ mmHg at 20°C
Vapor Density: Not applicable
Bulk Density: 0.36–0.40 g/cm³ (technical material)
Solubility in Water: 4.1 g/L at 20°C (high solubility for a pesticide)
Partition Coefficient (Log Kow): -0.13 (indicative of low bioaccumulation)
Decomposition Temperature: Begins to decompose above 190°C
Viscosity: Not applicable for solid
Molecular Weight: 291.7 g/mol
Chemical Stability: Stable under recommended storage and handling conditions; degradation may occur if exposed to moisture or light for extended periods.
Reactivity: Inert under normal usage conditions.
Conditions to Avoid: Excessive heat, open flame, incompatible materials, prolonged exposure to light.
Materials to Avoid: Strong oxidizing agents, acids, alkalis.
Hazardous Decomposition Products: Produces toxic gases including nitrogen oxides, sulfur oxides, hydrogen chloride under fire or extreme heating.
Polymerization: Not expected to occur.
Acute Oral Toxicity: LD50 (rat) = 1563 mg/kg (moderate toxicity)
Acute Dermal Toxicity: LD50 (rat) > 2000 mg/kg (low toxicological risk via skin absorption)
Acute Inhalation Toxicity: LC50 (rat, 4hr) = > 1.38 mg/L as dust/mist
Skin Irritation: Slightly irritating
Eye Irritation: Moderate irritation observed in animal studies
Skin Sensitization: Not expected to cause sensitization based on current research
Chronic Effects: Animal studies point toward liver and kidney changes after prolonged, high-level exposures
Carcinogenicity: Not listed as carcinogenic by IARC, ACGIH, OSHA, or NTP
Mutagenicity: Tests to date show no significant genetic toxicity
Reproductive Toxicity: No evidence of birth defects at low to moderate exposures; long-term/high exposures cause adverse effects in laboratory animals.
Ecotoxicity: Highly toxic to aquatic organisms (LC50 for rainbow trout: 100 mg/L, Daphnia: 17.6 mg/L, acute exposure); extremely toxic to honeybees (oral LD50 about 0.005 µg/bee)
Persistence and Degradability: Moderately persistent in soil (soil half-life can range from 7 to over 100 days depending on soil composition and climate)
Bioaccumulation: Not expected to bioaccumulate based on log Kow
Mobility in Soil: Mobile in many soil types due to high water solubility; detected in groundwater in some agricultural areas
Other Adverse Effects: May indirectly affect non-target insect populations, birds dependent on insects, and cause ecosystem shifts with repeated or large-scale use.
Methods of Disposal: Dispose unused material via licensed chemical waste contractor in accordance with environmental regulations; do not pour into drains or watercourses.
Container Handling: Rinse packaging three times (triple rinse), puncture to avoid reuse, send to landfill or chemical incinerator as per local laws; follow label directions.
Disposal of Spills: Collect contaminated soil and absorbents; treat as chemical waste.
Environmental Precautions: Avoid contamination of surface water, groundwater, agricultural land not intended for treatment; local agencies may have specific disposal advice.
UN Number: 2588
Proper Shipping Name: Pesticide, solid, toxic, n.o.s. (contains thiamethoxam)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Marine Pollutant: Yes
Labeling Requirements: “Toxic”, “Marine Pollutant” symbols; compliance with national and international regulations (IMDG, IATA, ADR)
Special Precautions: Avoid moisture, high temperature during transit; keep away from incompatible cargo.
EPA Status (US): Registered pesticide; label must contain EPA Registration Number; subject to FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act) regulations.
EU Regulation: Listed in EU Plant Protection Products Regulation, subject to restricted use in some countries due to pollinator risks.
Other National Regulations: Country-specific restrictions based on environmental and pollinator risk assessments; compliance with national worker protection standards required.
Inventory Listings: Listed in major chemical inventories (TSCA, EINECS/ELINCS, PICCS, AICS, DSL/NDSL, etc.) depending on product form.
Worker Protection: Label requirements for minimum personal protective equipment, re-entry intervals after application, restricted entry for non-trained individuals.
Community Right-to-Know: Required reporting under emergency planning regulations for large-scale users; local agencies may require additional notification.
