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Name: Tetrahydropyran
Chemical Formula: C5H10O
CAS Number: 142-68-7
Synonyms: Oxane, THP
Physical State: Clear, colorless liquid
Odor: Ether-like aroma signals presence in the air
Hazard Class: Flammable liquid and vapor
Acute Effects: Irritates eyes, nose, throat; high concentrations can lead to dizziness and headaches
Chronic Effects: Limited data; long-term effects unlikely at typical exposure with proper controls
Key Risk: Rapid evaporation in open spaces can quickly raise flammable gas levels
Symbols: Exclamation mark and flame pictograms under GHS classification
Substance: Single-component (Tetrahydropyran, ≥99%)
Impurities: Trace water and residual synthesis by-products
Inhalation: Get into fresh air quickly, loosen tight clothing; dizziness subsides on its own most times
Eye Contact: Rinse eyes gently with water for at least 15 minutes,
Skin Contact: Rinse off using mild soap and warm water; seek further care for persistent symptoms
Ingestion: Never induce vomiting, rinse mouth, drink water in small sips if conscious; head to medical care for larger exposures
Suitable Extinguishers: Powder, foam, CO2 extinguishers work best
What to Avoid: Direct water jets can spread burning liquid
Notable Hazards: Flammable vapor mixes with air and can travel far, then ignite; closed containers may rupture when exposed to fire
Protective Gear: Firefighters put on full turnout gear and self-contained breathing apparatus
Personal Protection: Wear splash goggles, gloves, and chemical-resistant boots
Environmental Spread: Keep away from drains, soil, and open waterways
Small Spills: Absorb using inert material like sand or vermiculite
Ventilation: Open windows or fans help clear fumes
Safe Handling: Avoid sparks, flames, and static build-up; transfer using grounded equipment
Storage: Keep containers tightly closed, store in a cool, dry, well-ventilated spot away from oxidizers and acids
Incompatibilities: Strong acids, aluminum, and oxidizing agents can trigger unwanted reactions
Engineering Controls: Fume hoods or local exhaust ventilation in labs or processing areas
Personal Protection: Safety goggles, nitrile gloves, and lab coats stand between user and exposure
Threshold Limit: No established regulatory exposure limit, so better to keep levels as low as possible through controls
Appearance: Clear liquid
Boiling Point: Around 88°C (190°F)
Melting Point: -75°C
Flash Point: About 4°C (39°F)
Solubility: Mixes moderately with water
Vapor Pressure: Relatively high at room temperature, promotes quick evaporation
Stability: Remains stable under usual handling and storage conditions
Reactivity: Risk rises with heating, mixing with oxidizers—produces peroxides over extended storage
Decomposition: Gives off carbon monoxide and other toxic fumes if burned or heated intensely
Acute Toxicity: Low overall, ingestion or large-scale inhalation triggers nausea, CNS depression, and in rare cases, unconsciousness
Irritation: Contact may sting skin, eyes, and respiratory tract
Carcinogenicity: No conclusive evidence for cancer risk, and not listed as carcinogenic by IARC or OSHA
Aquatic Effects: Breaks down in water, but can still cause harm to aquatic life in high concentrations
Persistence: Tends to degrade over time with sunlight and microbial action
Bioaccumulation: Unlikely due to fast breakdown and volatility
Disposal Method: Treat as chemical waste—incinerate in a licensed facility, follow local and national rules
Container Management: Empty cans and bottles should be rinsed, then handled as hazardous waste
UN Number: UN 1993
Class: 3 (Flammable liquid)
Packing Group: III (Moderate danger during transport)
Guide: Ship in tightly sealed, labeled drums or bottles; avoid bumping or extreme temps during transit
Hazard Symbols: GHS Flammable and Irritant labels result from recognized fire and health risks
Chemical Inventory: Registered in programs like TSCA (US), REACH (EU)
Workplace Rules: OSHA chemical hygiene plans, local fire code, and EPA guidelines all carry weight
