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Product Name: Tamoxifen Citrate
Synonyms: Nolvadex, Tam, Tamoplex, Tamoxifenum, Tamoxifene
Chemical Formula: C32H37NO8
CAS Number: 54965-24-1
Intended Use: Pharmaceutical, research and laboratory uses
Manufacturer/Supplier: Refer to package label
Emergency Telephone: Refer to manufacturer’s emergency contact
GHS Classification: Carcinogenicity Category 1B, Reproductive Toxicity Category 1B, Specific Target Organ Toxicity (repeated exposure) Category 2
Signal Word: Danger
Hazard Statements: May cause cancer; May damage fertility or unborn child; May cause harm to breastfed children; Causes damage to organs through prolonged or repeated exposure
Pictograms: Health hazard symbol
Precautionary Statements: Do not handle until all safety precautions are understood; Wear protective equipment; Avoid breathing dust; Wash thoroughly after handling; Keep away from children and pregnant or breastfeeding women
Chemical Name: Tamoxifen Citrate
Concentration: 100% (pure substance); preparations may vary
CAS Number: 54965-24-1
Impurities/Additives: Minimal, pharmaceutical grade
Inhalation: Remove to fresh air immediately; seek medical attention if symptoms develop such as coughing, throat irritation, or difficulty breathing
Skin Contact: Wash with generous amounts of soap and water; remove contaminated clothing; seek medical help if irritation develops
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; consult ophthalmologist
Ingestion: Rinse mouth; do not induce vomiting unless on advice from medical personnel; seek immediate medical attention
Most Important Symptoms: Possible signs include nausea, irritation, headache, dizziness, and effects on reproductive system; in large exposures risk carcinogenic or developmental effects increases
Suitable Extinguishing Media: Use CO2, dry chemical, or foam; water spray for larger fires
Specific Hazards: Combustion products may include toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides
Special Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus
Special Procedures: Move containers from area if safe; prevent run-off to drains and water bodies
Explosion Sensitivity: Tamoxifen citrate is not known to be explosive under normal handling conditions
Personal Precautions: Evacuate unnecessary personnel; avoid contact with skin, eyes, or inhalation of dust
Protective Equipment: Wear gloves, safety goggles, lab coat, and approved dust mask or respirator
Environmental Precautions: Prevent release to sewers, surface and ground water
Clean-Up Methods: Sweep up using methods to minimize dust generation; collect in closed containers for disposal; wash area thoroughly after cleanup
Disposal of Contaminated Materials: Treat as hazardous waste and dispose in accordance with local regulations
Handling: Use in chemical fume hood or well-ventilated area; avoid dust formation and inhalation; keep away from food, beverages, and smoking materials
Storage: Keep container tightly closed in a cool, dry place away from incompatible substances such as strong oxidizers; store in original packaging or suitable labeled container
Special Requirements: Secure storage away from children, pregnant or breastfeeding individuals, and unauthorized personnel; use caution to avoid spills and leaks
Occupational Exposure Limits: No specific OSHA or ACGIH exposure limits; handle as hazardous substance
Engineering Controls: Use local exhaust ventilation and chemical fume hoods; avoid open handling
Personal Protective Equipment: Nitrile gloves, safety goggles or face shield, lab coat or chemical-resistant apron
Respiratory Protection: Approved NIOSH respirator in cases of dust formation
Hygiene Measures: Wash hands and exposed skin after handling; do not eat, drink, or smoke during use
Appearance: White to off-white crystalline powder
Odor: Odorless or faint odor
pH: No data available
Melting Point: 140–144 °C (284–291 °F)
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water; soluble in ethanol, methanol, DMSO
Vapor Pressure: No data available
Partition Coefficient: log P = 6.3
Stability in Solution: Stable for storage as packaged; sensitive to excessive light, heat, strong acids, and oxidizing agents
Chemical Stability: Stable under normal conditions and recommended storage
Reactivity: No known significant reactivity hazards under standard conditions
Conditions to Avoid: Heat, sunlight, moisture, strong oxidizers, acidic or basic environments
Incompatible Materials: Strong oxidizers, strong acids, bases
Hazardous Decomposition Products: May produce toxic gases like CO, CO2, nitrogen oxides on thermal decomposition
Acute Toxicity: Oral LD50 (rat) > 2,000 mg/kg; low acute toxicity but long-term exposure increases health risks
Skin/Eye Irritation: May cause mild irritation to skin and eyes
Carcinogenicity: Human carcinogen, classified as Group 1 by IARC
Reproductive Toxicity: Animal studies show reproductive toxicity and possible developmental effects
Sensitization: Not considered a skin sensitizer
Target Organs: Liver, reproductive organs, mammary glands
Chronic Effects: Risk of endometrial cancer, thrombosis, cataracts, changes in liver function with prolonged exposure
Other Information: Avoid exposure for pregnant or nursing women
Ecotoxicity: Harmful to aquatic organisms even in low concentrations; long-term adverse effects possible in aquatic environments
Mobility: Limited mobility in soil; low volatility
Persistence and Degradability: Not readily biodegradable; persists in environment
Bioaccumulation Potential: Potential to bioaccumulate in aquatic organisms
Other Adverse Effects: Avoid discharge to water bodies or soil; effects extend to wastewater systems
Waste Disposal Methods: Dispose of unused or contaminated material through licensed hazardous waste contractor; follow local, regional, national regulations
Container Handling: Triple rinse empty containers before disposal; crush or dismantle to prevent reuse
Environmental Caution: Do not release to environment, rivers, lakes, sewers; incinerate in approved facility where practical
UN Number: Not assigned
Proper Shipping Name: Tamoxifen citrate is generally not considered dangerous for transport under UN, IMO, ADR, or IATA regulations
Transport Hazard Class: Not classified as a hazardous material
Packing Group: None applicable
Special Precautions: Ship according to good chemical handling practices; protect package from moisture and rupture
US TSCA: Not listed for commercial use
OSHA Hazard Communication Standard: Regulated as a hazardous chemical
SARA Title III: Not listed as an extremely hazardous substance
California Proposition 65: Listed chemical known to cause cancer
IARC: Group 1 Carcinogen (Human)
EU REACH: Regulated substance
Other Regulations: Subject to pharmaceutical regulations and safe handling protocols in licensed facilities; refer to local, national, and international regulations for additional requirements
