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Material Safety Data Sheet (MSDS) for Scopolamine Hydrobromide

Identification

Product Name: Scopolamine Hydrobromide
Chemical Formula: C17H21NO4•HBr
Synonym: Hyoscine hydrobromide
CAS Number: 6533-68-2
Product Use: Pharmaceutical agent, research chemical
Manufacturer Information: Contact information for supplier or manufacturer required for traceability and emergency procedures
Emergency Telephone Number: National Poison Control or company emergency hotline

Hazard Identification

GHS Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Specific target organ toxicity
Label Elements: Skull and crossbones (toxic), exclamation mark
Signal Word: Danger
Hazard Statements: Causes serious eye irritation, may be toxic if swallowed, may cause respiratory irritation, harmful through skin absorption, may affect nervous system
Precautionary Statements: Avoid breathing dust or vapors, use protective equipment, wash hands thoroughly after handling, do not eat or drink during use
Potential Health Effects: Drowsiness, confusion, hallucinations, dry mouth, blurred vision, rapid heartbeat, agitation

Composition / Information on Ingredients

Chemical Name: Scopolamine Hydrobromide
Purity: Typically 98% or higher
Impurities: May contain trace levels of related tropane alkaloids
Other Ingredients: None reported if supplied pure
EC Number: 229-393-2

First Aid Measures

Eye Contact: Flush with water for at least 15 minutes, seek medical attention
Skin Contact: Remove contaminated clothing, wash affected area with soap and water, get medical attention if irritation develops
Inhalation: Move to fresh air, provide artificial respiration if needed, seek prompt medical advice
Ingestion: Rinse mouth, do not induce vomiting, give water only if conscious, immediate medical help is critical
Main Symptoms/Effects: Hallucinations, dry mouth, dilated pupils, rapid heartbeat, possible loss of consciousness
Immediate Medical Attention Needed: Always recommended for exposure

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Media: Avoid strong water jets direct impact may spread powders
Fire Hazards: Emits toxic fumes under fire conditions (carbon oxides, nitrogen oxides, hydrogen bromide)
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Hazards: Combustion releases irritant or toxic gases
Advice: Move containers from fire area if safe, use water spray to cool unopened containers

Accidental Release Measures

Personal Precautions: Use personal protective equipment such as gloves, goggles, and protective clothing to prevent skin and eye contact
Environmental Precautions: Prevent entry into drains, sewers, or waterways, contain spillage with inert materials such as sand or earth
Methods for Clean Up: Scoop or sweep up without generating dust, place into properly labeled waste container, ventilate and wash spill area
Decontamination: Wash spill area thoroughly with water after removal
Disposal: Dispose following all federal, state, and local regulations

Handling and Storage

Safe Handling: Avoid contact with eyes, skin, and clothing, use in well-ventilated areas, avoid breathing dusts or vapors, after use, wash hands and face
Storage Conditions: Store in tightly closed containers, in a cool, dry, and well-ventilated place, protect from light, keep away from incompatible substances such as strong oxidizers and acids
Incompatibilities: Strong oxidizing agents, strong acids, light, moisture
Container Materials: Use chemically compatible materials to prevent reactions or leakage
Other Precautions: Keep out of reach of unauthorized personnel and children

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific OSHA or ACGIH exposure limits, use with caution as effects occur at very low doses
Engineering Controls: Work in fume hood or local exhaust ventilation
Personal Protective Equipment: Gloves (nitrile or neoprene), safety goggles, lab coat, respiratory protection if exposure risk is high
Hygiene Measures: Do not eat, drink, or smoke in work areas, wash hands before breaks and at end of shift, remove contaminated clothing before leaving the work area

Physical and Chemical Properties

Appearance: White or pale crystalline powder
Odor: Odorless
Melting Point: Decomposes before melting, above 150°C
Solubility: Freely dissolves in water and alcohol
pH: Aqueous solutions typically slightly acidic
Boiling Point: Decomposes before boiling
Vapor Pressure: Not volatile under normal conditions
Flash Point: Not applicable—not a flammable solid under normal use
Relative Density: Approximately 1.5 g/cm³
Partition Coefficient (log Pow): Data not readily available; substance considered hydrophilic due to salt form
Other Information: Sensitive to light, may turn yellow-brown on prolonged exposure

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures if kept dry and protected from light
Reactivity: No hazardous reactivity under normal conditions, will react with strong oxidizers or acids
Decomposition Products: Bromine-containing gases, nitrogen oxides, carbon oxides
Hazardous Polymerization: Does not occur
Conditions to Avoid: Excess heat, light, moisture, contact with strong oxidizers or strong acids

Toxicological Information

Routes of Exposure: Inhalation, oral ingestion, dermal absorption, eye contact
Acute Toxicity: Highly toxic, symptoms may include hallucinations, respiratory distress, tachycardia, confusion, mydriasis, convulsions
LD50 (Oral, Rat): About 400 mg/kg
Chronic Effects: No known evidence for carcinogenicity, mutagenicity, or reproductive toxicity, repeated exposure causes cumulative nervous system effects
Target Organs: Central nervous system, eyes, heart
Sensitization: No widespread evidence, but may cause allergic response in susceptible individuals
Other Information: Delirium and seizures possible at high doses

Ecological Information

Ecotoxicity: No extensive ecotoxicological data available, suspected hazardous to aquatic life based on structural similarity to related compounds
Persistence and Degradability: Readily degrades in presence of sunlight or soil bacteria, not persistent in environment
Bioaccumulation Potential: Low, compound is water soluble and expected to be mobile in aquatic systems
Mobility in Soil: Likely to migrate in water due to high solubility
Other Adverse Effects: Avoid release into waterways to prevent possible harm to plants and animals

Disposal Considerations

Waste Disposal: Dispose of via licensed chemical waste contractor, consult local, regional, and national authorities
Contaminated Packaging: Clean thoroughly or incinerate as hazardous waste
Special Precautions: Do not dispose in household garbage, do not allow to enter public drains or the environment
Recommended Practices: Label and seal all waste, store in suitable container until disposal

Transport Information

UN Number: 2811
Proper Shipping Name: Toxic solids, organic, n.o.s. (contains Scopolamine Hydrobromide)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III (Substances presenting a relatively low acute toxicity hazard)
Marine Pollutant: Not classified as marine pollutant by available regulations
Special Precautions for Transportation: Keep away from food and feedstuffs, transport in secure, sealed containers
Regulatory Status: Subject to special regulations under transport of dangerous goods laws

Regulatory Information

TSCA: Not listed for commercial distribution in the USA
DSL/NDSL (Canada): Not listed
EU Reach: Restrictions on supply due to toxicological profile, pharmaceutical regulations apply
OSHA Regulatory Status: Considered hazardous by OSHA under 29 CFR 1910.1200
Other National Inventories: Check for specific local or state restrictions
Other Regulations: Subject to handling and prescription controls in many countries, environmental releases regulated by hazardous waste statutes