© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Rifampin
Chemical Name: 3-(4-Methyl-1-piperazinyl)imino-methyl rifamycin
CAS Number: 13292-46-1
Molecular Formula: C43H58N4O12
Molecular Weight: 822.94 g/mol
Synonyms: Rifampicin, RMP
Manufacturer: Varies by supplier; commonly produced by pharmaceutical companies globally
Recommended Use: Antibiotic treatment for tuberculosis, leprosy, and certain bacterial infections
Emergency Number: Refer to local regulations; obtain number from supplier’s SDS.
GHS Classification: Acute toxicity (oral, inhalation, dermal), skin sensitization, specific target organ toxicity
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction, harmful if swallowed, suspected of causing cancer (based on animal data), may damage fertility or the unborn child, causes serious eye irritation
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust, use only outdoors or in a well-ventilated area, wear protective gloves, wash hands thoroughly after handling, avoid contact with eyes and skin.
Substance: Rifampin
Purity: Typically ranges from 98% to 100%
Impurities: Trace organic solvent residues, potential starting-material traces
Form: Orange-red crystalline powder
Concentration: 100% active ingredient in pure form, often mixed for pharmaceutical applications.
Inhalation: Move to fresh air; call a physician if symptoms like cough or shortness of breath occur
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and plenty of water
Eye Contact: Rinse abundantly with water for at least 15 minutes, remove contact lenses before flushing
Ingestion: Rinse mouth, call poison control immediately, seek medical help right away
Symptoms: Symptoms may include rash, redness, nausea, vomiting, abdominal pain, allergic reaction signs
Advice for Doctors: No specific antidote known; treat symptomatically and provide supportive care.
Suitable Extinguishing Media: Use water spray, foam, dry chemical or carbon dioxide
Unsuitable Media: Strong water jet (may spread powder)
Hazardous Combustion Products: Produces nitrogen oxides, carbon monoxide, carbon dioxide, may release toxic fumes
Firefighter Protective Equipment: Full protective gear and self-contained breathing apparatus recommended
Special Hazards: Dust may form explosive mixtures with air; avoid generating dust clouds within confined spaces.
Personal Precautions: Isolate area, wear suitable protective clothing including gloves and eye protection
Environmental Precautions: Avoid release into drains, watercourses, or soil
Cleanup Methods: Carefully sweep up, avoiding dust formation, and place in closed containers for disposal; clean spill area with damp paper towels
Disposal: Dispose of waste in accordance with local, regional, national, and international regulations
Ventilation: Ensure adequate ventilation during cleanup.
Handling Precautions: Use only in areas with proper exhaust ventilation, wear personal protective equipment, minimize dust generation, wash hands thoroughly after handling, avoid contact with skin and eyes
Safe Storage: Store in tightly closed containers in a cool, dry, and well-ventilated place, away from incompatible materials like strong acids and oxidizers
Temperature Requirements: Maintain storage temperature between 2°C and 8°C (refrigerator conditions) unless otherwise specified
Container Recommendations: Use amber-colored vials to protect from light, label containers clearly.
Engineering Controls: Use local exhaust or fume hood, maintain negative pressure in handling areas
Occupational Exposure Limits: No established OSHA or ACGIH limits; pharmaceutical workplaces set their own controls (<100 µg/m3 for API handling)
Personal Protective Equipment: Standard lab coat, nitrile or latex gloves, safety goggles or face shield, NIOSH-approved respirator for dust
Hygiene: Do not eat, drink, or smoke during use; wash hands before breaks and after work, remove and wash contaminated clothing before reuse.
Appearance: Orange-red crystalline powder
Odor: Odorless or slight odor
pH (1% solution): Approximately 7.0–8.5
Melting Point: 183-188°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in chloroform, slightly soluble in water
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Pow): Approximately 2.7
Flash Point: Not applicable (solid)
Density: About 1.3–1.5 g/cm³.
Chemical Stability: Chemically stable under recommended storage conditions
Reactivity: Incompatible with strong oxidizing agents, acids, alkalis; may degrade rapidly in sunlight or light exposure
Decomposition Products: Nitrogen oxides, carbon oxides, possible toxic fumes
Hazardous Polymerization: Will not occur under normal storage and handling.
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat): 3,120 mg/kg; low acute toxicity
Chronic Effects: Repeated exposure may cause liver damage, can discolor body fluids, may provoke hypersensitivity
Carcinogenicity: Not classed as carcinogenic to humans, suspicions exist from animal studies
Sensitization: Known to cause skin sensitization, rare cases of severe allergic reaction
Reproductive Toxicity: Evidence for developmental risk in animal models, caution advised for pregnant women.
Ecotoxicity: Harmful to aquatic organisms; may cause long-term adverse effects in aquatic environments
Persistence and Degradability: Partially biodegradable; breakdown may take time due to complex structure
Bioaccumulation Potential: Low potential based on physical-chemical properties
Mobility in Soil: Bound to soil, but small amounts may leach depending on environmental conditions
Other Adverse Effects: Pharmaceutical residues found in wastewater; proper disposal required to limit impact.
Waste Treatment Methods: Collect and transfer contents to suitable disposal container, incinerate in compliance with local requirements
Disposal of Product: Follow hazardous pharmaceutical waste protocols; never discard in sewage systems or general trash
Contaminated Packaging: Handle as hazardous waste, decontaminate if possible before reusing
Regulations: Abide by country-specific regulations and WHO guidelines for cytotoxic and pharmaceutical waste.
UN Number: Not classified as a hazardous material for transport under ADR, IMDG, IATA rules
Proper Shipping Name: Rifampin
Transport Hazard Class: Not regulated as dangerous by air, sea, or ground
Packing Group: None assigned
Special Precautions: Secure containers to prevent leakage, label clearly, avoid extreme temperatures during transport
Environmental Hazards: Not considered marine pollutant, nevertheless avoid large spillages to minimize contamination.
TSCA (US): Not listed
OSHA Hazardous Chemical: Yes
WHMIS (Canada): D2B (Toxic material causing other toxic effects)
EU Regulation: Not classified as dangerous in the sense of EC directives; must comply with REACH registration if handling large quantities
International Inventories: Relevant national regulations for pharmaceuticals apply
Other Regulations: Prescription drug under FDA; use strict workplace controls as per occupational health authority guidance; follow local, state, and federal mandates on worker safety and environmental protection.
