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Product Name: Retinyl Acetate
Chemical Name: Retinol acetate
Synonyms: Vitamin A acetate
CAS Number: 127-47-9
Recommended Use: Ingredient in pharmaceuticals, cosmetics, and dietary supplements
Manufacturer Information: Contact details as provided on packaging or supplier documentation
Emergency Contact: Local poison control or healthcare facility
Classification: Harmful if swallowed, skin and eye irritant, suspected reproductive hazard
Signal Word: Warning
Hazard Statements: May cause irritation to eyes, skin, and respiratory tract; can cause birth defects or reproductive toxicity with chronic exposure; may be harmful if inhaled or absorbed through skin
Precautionary Statements: Wear protective gloves, clothing, and eye protection; wash hands thoroughly after handling; avoid breathing dust or vapors; use in a well-ventilated area
Chemical Identity: Retinyl Acetate
Concentration: Typically >98%
Impurities: Trace stabilizers or antioxidants may be present in small quantities
Molecular Formula: C22H32O2
Molecular Weight: 328.49
General Advice: Seek medical attention for any persistent symptoms or in case of doubt
Inhalation: Move to fresh air, keep at rest, provide oxygen if breathing is difficult
Skin Contact: Remove contaminated clothing, wash skin with soap and water, seek medical attention for irritation
Eye Contact: Rinse eyes slowly and gently with water for at least 15 minutes, remove contact lenses if present, consult an ophthalmologist for persistent symptoms
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical attention; show this safety data sheet to responding medical personnel
Suitable Extinguishing Media: Use dry chemical powder, alcohol-resistant foam, carbon dioxide, or water spray
Unsuitable Extinguishing Media: Direct water jets may cause spread of fire
Hazards from Combustion: May emit toxic fumes including carbon monoxide, carbon dioxide, and acetic acid vapors under fire conditions
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Recommendations: Cool surrounding containers with water spray, prevent fire-fighting run-off from entering drains or watercourses
Personal Precautions: Evacuate area, avoid breathing dust or vapors, use personal protective equipment including gloves and goggles
Environmental Precautions: Prevent entry into soil, drains, waterways, or sewers
Methods for Cleanup: Absorb with inert material such as sand or vermiculite, collect and place in secure labeled containers for disposal, clean contaminated area with detergent and water
Additional Notes: Ensure adequate ventilation, limit area of exposure, follow local regulations for disposal
Handling: Use only in well-ventilated settings, avoid contact with skin, eyes, and clothing, avoid inhaling dust or vapors, wear recommended protective equipment, keep containers securely closed
Storage Conditions: Store in tightly sealed containers, protect from light, heat, and moisture, keep away from incompatible materials such as strong acids, alkalis, and oxidizers, separate from food and feedstuffs, maintain temperature between 2-8°C unless product label instructs otherwise
Special Requirements: Check for possible leaks or spills regularly, use non-sparking tools and explosion-proof equipment as necessary
Exposure Limits: No established occupational exposure limits; follow good chemical hygiene practices
Engineering Controls: Use local exhaust ventilation to limit airborne exposure, maintain negative air pressure in workplace to control vapors
Personal Protection: Wear protective gloves (nitrile recommended), chemical-splash safety goggles, lab coat or apron, and in dusty conditions use a NIOSH-approved particulate respirator
Hygiene Measures: Change clothing and wash hands after handling, avoid eating, drinking, or smoking during use, keep work area clean
Appearance: Yellow to orange, viscous oily liquid or solid depending on temperature
Odor: Slight characteristic odor
pH: Not applicable (insoluble in water)
Melting Point: 57°C - 60°C (if solidified)
Boiling Point: Not precisely determined, decomposes upon heating
Flash Point: >110°C (closed cup)
Evaporation Rate: Not determined
Solubility: Practically insoluble in water, soluble in fats, oils, and organic solvents such as ethanol and chloroform
Vapor Pressure: Very low at room temperature
Density: 0.97 - 0.99 g/cm³ at 20°C
Partition Coefficient (n-octanol/water): Log Pow: 7.44 (estimated)
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: May react with strong oxidizers, acids, and alkalis
Conditions to Avoid: Excessive heat, light, air, moisture
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, acetic acid, irritant fumes
Polymerization: Will not occur under normal processing
Acute Toxicity: Estimated oral LD50 (rat): 1510 mg/kg; may be harmful if swallowed
Skin Corrosion/Irritation: May cause mild to moderate irritation with repeated or prolonged contact
Eye Damage/Irritation: May cause irritation and redness
Respiratory Sensitization: Not classified as a respiratory sensitizer, although dust or vapors may irritate the airways
Germ Cell Mutagenicity: Not classifiable based on available data
Carcinogenicity: Not classified as a known or probable human carcinogen
Reproductive Toxicity: Overexposure and chronic intake lead to possible teratogenic effects, birth defects, liver toxicity
Other Information: High doses through ingestion, especially long-term, can result in symptoms including headache, nausea, vomiting, skin desquamation, bone pain, and hepatic dysfunction
Ecotoxicity: Data limited; expected to pose low to moderate threat to aquatic life; bioaccumulation possible based on log Pow value
Persistence and Degradability: Slowly biodegradable in soil and water, breakdown influenced by light and microbial action
Bioaccumulative Potential: High due to hydrophobic nature and log Pow above 7
Mobility in Soil: Low solubility in water, likely to adsorb to organic material in soil and sediments
Other Adverse Effects: Do not allow release to environment without proper waste controls
Product Disposal: Collect and place in sealed, clearly labeled containers, follow all local, state, and federal regulations for hazardous waste, incinerate or send to licensed chemical disposal facility
Contaminated Packaging: Triple-rinse containers, offer for recycling if available, otherwise dispose of as hazardous material
Avoid Disposal: Do not discharge or release into sewers, water courses, or soil
UN Number: Not classified as a hazardous material for land, air, or sea transport in most jurisdictions
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Special Precautions: Ensure containers remain tightly sealed and protected from physical damage during transport, avoid temperature extremes
Inventory Listings: US TSCA, EU EINECS, Canadian DSL, Australian AICS, and other national inventories as applicable
Regulatory Status: Check country-specific legislation for any additional restrictions on use, import, export, or disposal
Labeling Requirements: Use recognized hazard pictograms and warnings for substances classified under GHS or local rules
Other Standards: Compliant with OSHA Hazard Communication Standard, European CLP, and relevant sections of the FDA Code of Federal Regulations where applicable
