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Product Name: Quinidine
Chemical Formula: C20H24N2O2
Synonyms: (S)-Quinidine, Cinchonan-9-ol, 6'-methoxy-, (9S)-
CAS Number: 56-54-2
Intended Use: Pharmaceutical intermediate, research chemical
Manufacturer: Refer to supplier documentation
Emergency Contact: Check local or national emergency phone numbers provided on the package
GHS Classification: Acute Toxicity (Oral), Category 3; Eye Irritation, Category 2A; Skin Sensitization, Category 1
Signal Word: Danger
Hazard Statements: Toxic if swallowed, causes serious eye irritation, may cause an allergic skin reaction
Precautionary Statements: Avoid breathing dust or contact with eyes and skin, wash hands thoroughly after handling, use appropriate personal protective equipment
Potential Health Effects: Harmful effects on heart rhythm, possible blood disorders, gastrointestinal and neurological symptoms, contact can irritate eyes and skin
Chemical Name: Quinidine
Purity: ≥ 98%
CAS Number: 56-54-2
Impurities: Trace alkaloids and related compounds (specify through COA if available)
Additives: None indicated
Inhalation: Move affected person to fresh air, seek immediate medical advice if symptoms occur
Skin Contact: Remove contaminated clothing, wash with soap and plenty of water, get medical attention for persistent irritation
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, consult an eye specialist
Ingestion: Rinse mouth, do not induce vomiting, seek urgent medical evaluation due to toxicity
Most Important Symptoms: Nausea, vomiting, arrhythmia, contact dermatitis, dizziness, possible convulsions
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Extinguishing Media: Do not use high-pressure water streams
Special Hazards: Risk of toxic fumes including nitrogen oxides, carbon monoxide, and carbon dioxide from combustion
Protective Equipment: Full protective clothing and self-contained breathing apparatus required for firefighters
Explosion Risk: Dust may form explosive mixtures with air
Advice for Firefighters: Avoid inhalation of combustion products; contain and collect contaminated water for proper disposal
Personal Precautions: Use personal protective equipment such as gloves, goggles, and a lab coat
Environmental Precautions: Avoid discharge into drains, watercourses, or soil
Containment Methods: Ventilate the area, prevent further leakage or spillage if it can be done safely
Cleanup Methods: Collect spillage with a vacuum or damp cloth, place in appropriate closed container for disposal, decontaminate area with detergent and water
Precautions for Safe Handling: Work with proper engineering controls, minimize dust generation, avoid inhalation, use in well-ventilated space, keep containers tightly closed
Hygiene Measures: Wash hands thoroughly after use, eat or drink only away from work area
Storage Conditions: Store away from incompatible substances such as strong oxidizers, acids, and bases, keep in cool, dry, well-ventilated area
Packaging Materials: Use original containers, keep containers closed when not in use, label clearly for identification
Incompatibilities: Avoid storage near sources of ignition and moisture, do not mix with strong oxidizers
Occupational Exposure Limits: No established exposure limits for quinidine; control exposure to minimize risks
Engineering Controls: Work in a chemical fume hood or with adequate ventilation
Eye Protection: Chemical safety goggles or face shield
Skin Protection: Wear chemical-resistant gloves (nitrile or latex), long-sleeved clothing
Respiratory Protection: Dust mask or respirator (N95 or higher) if dust formation is possible
Environmental Protection: Use closed systems for handling bulk quantities, prevent spillage to the environment through proper containment
Appearance: White to off-white crystalline powder
Odor: Slight, characteristic
Molecular Weight: 324.42 g/mol
pH: Typically neutral in aqueous solutions
Melting Point: 174–175°C
Boiling Point: Decomposes
Solubility: Freely soluble in water, alcohol, and organic solvents
Flash Point: No data available, expected to be high due to solid state
Partition Coefficient (log Kow): 3.25 (estimated)
Vapor Pressure: Negligible at ambient temperature
Auto-Ignition Temperature: Not readily combustible
Chemical Stability: Stable under normal conditions and proper storage
Reactivity: No dangerous reaction known under standard handling
Conditions to Avoid: Heat, humidity, light exposure, open flames
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Hazardous Decomposition Products: May generate noxious fumes including carbon monoxide, carbon dioxide, nitrogen oxides upon combustion or decomposition
Acute Toxicity: Oral LD50 (rat) 641 mg/kg; toxic if ingested
Chronic Exposure: Risk of cardiac arrhythmia, blood dyscrasia, liver and kidney effects according to animal and limited human data
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Effects: Irritation to mucous membranes, central nervous system depression, convulsions at high dose, allergic skin reactions
Carcinogenicity: Not classified as carcinogenic
Mutagenicity: No data indicating mutagenic effects
Reproductive Toxicity: Limited studies, use with caution if pregnant or breastfeeding
Aquatic Toxicity: Harmful to aquatic life with long-lasting effects
Persistence and Degradability: Moderate persistence in the environment, partial biodegradation expected
Bioaccumulative Potential: Potential for bioaccumulation in aquatic organisms
Mobility in Soil: Likely to have moderate mobility; may leach to groundwater if released uncontrollably
Other Adverse Effects: No data on ozone depletion, not a volatile organic compound of environmental concern
Product Disposal: Treat as hazardous pharmaceutical waste, dispose of through authorized chemical waste disposal facility
Contaminated Packaging: Incinerate or land-fill in accordance with local, state, and federal environmental regulations
Precautions: Do not discharge into drains, surface water, or soil; avoid release to the environment
Disposal Methods: Chemical incineration with flue gas scrubber or secure landfill, maintain closed containers throughout process
UN Number: Not regulated for transport under most international regulations
Proper Shipping Name: Quinidine
Transport Hazard Class: Not classified as hazardous for ground, air or sea transport
Packing Group: Not assigned
Marine Pollutant: Not designated
Special Precautions: Avoid transport with incompatible substances, ensure packaging is secure and clearly labeled, keep away from moisture and heat
Labelling Requirements: Chemical hazard label required under local regulations
OSHA HazCom Standard: Material considered hazardous
SARA Title III: Not subject to reporting
TSCA Status: Listed
REACH Status: Exempt as a pharmaceutical in finished form
Other Regulations: Subject to regulation by drug enforcement agencies where quinidine is a controlled substance, observe all safety and workplace regulations
