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Propyl Butyrate: More Than a Sweet Smell in the Lab

Historical Development

The story of propyl butyrate, like so many chemical discoveries, began with curious scientists testing combinations of alcohols and acids. Back in the 19th century, researchers saw how simple esters could be made by mixing acids and alcohols with a touch of acid catalyst, giving off fruity aromas. Propyl butyrate came into view as one of those unsung heroes, less famous than isoamyl acetate or ethyl butyrate, but quietly essential for flavorists and chemists. Over the decades, people learned that this compound brought far more than just a pleasant smell. Its structure, properties, and effects offered insights into organic chemistry’s potential. Even in its early days, propyl butyrate stood out as an example of how simple molecular tweaks unlock powerful results. From postwar food science to flavor creation during rapid industrialization, its presence reflected shifts in taste and technology.

Product Overview

Propyl butyrate often pops up behind the scenes in the fragrances of flavored drinks, candies, and baked goods. Its aroma, reminiscent of pineapple or pear, grabs the nose with a light, sweet note that brings depth to artificial and natural products. You’d be hard-pressed to find it on a grocery store shelf, but food scientists and cosmetic formulators know its value. Beyond snacks and scent, industrial uses range from creating specialty coatings to imparting a specific volatility profile for paints and inks. People drawn to chemistry sometimes discover propyl butyrate in university teaching labs or as a control sample in high-performance liquid chromatography. Having worked in labs for years, one never forgets the powerful smell that leaks out of a slightly loose cap, sending the entire room on a mental trip to the produce aisle.

Physical and Chemical Properties

In physical terms, propyl butyrate comes across as a colorless liquid with a distinctive, heavy fruit aroma. Its boiling point sits comfortably above room temperature, falling in the range typical for simple esters. Its solubility in water is minimal, nothing surprising there—like most esters, it prefers the company of organics. The molecular structure brings together a three-carbon alcohol and a four-carbon acid to produce a compound with a slippery, low-viscosity feel between the fingers, if you’re lucky enough to handle it directly. Vapor pressure and the flashpoint remind anyone storing or using it that care matters; volatile esters have a habit of evaporating aggressively and catching a spark with ease. Anyone handling it in a lab will feel the oiliness and catch a whiff well before any dangerous amounts drift into the air.

Technical Specifications and Labeling

Standards for labeling typically follow regional and international guidelines. It falls under the purview of REACH in Europe, and the Food Chemicals Codex outlines benchmarks for purity and contaminants for food-related uses. Manufacturers usually present propyl butyrate in concentrations tailored for specific industries, documented by CAS number and batch data. Labels point out flammability, chemical reactivity, and hazard warnings, plus storage advice. For chemists, it’s second nature to double-check these specs before opening a bottle, because nobody likes being caught off guard by a flash fire or surprise chemical interaction. Ingredient panels in food rarely feature the compound by name; it blends into obscure “natural flavors” language governed by local law and standards.

Preparation Method

Researchers usually make propyl butyrate through an esterification reaction using butyric acid and n-propanol, catalyzed by strong acids like sulfuric acid. The reaction produces water alongside the ester, making continuous separation or water removal a critical strategy for increasing yield. During graduate school, I saw failed attempts at esterification because a group didn’t remove water—yields plummeted, and so did morale. Newer industrial methods explore using solid acid catalysts and even biocatalysis with lipases for greener, more efficient processes. Process control stays vital, as temperature, acid concentration, and removal techniques can all decide between trace yields or a bumper crop in the distillation flask.

Chemical Reactions and Modifications

Propyl butyrate, being an ester, reacts in predictable ways. Subjecting it to hydrolysis splits the molecule back to its parent alcohol and acid, which can cause headaches for anyone storing it in humid conditions or leaving it in the presence of excess water and heat. Acid or base catalysis hastens this process. Chemical folks have looked into modifying the alcohol or acid portions to fine-tune aroma, volatility, or functional properties. Hydrogenation isn’t as relevant here, but transesterification can change the profile in a controlled way, opening doors for manufacturing specialty flavors. Stability studies form a crucial part of any research—exposing the compound to light, heat, and air gives insight into shelf life and storage tweaks.

Synonyms and Product Names

If you scan scientific catalogs or regulatory registers, propyl butyrate shows up under multiple names: n-Propyl butanoate, butanoic acid propyl ester, and a handful of trade names. Flavor industry insiders sometimes use code numbers or blend designations on data sheets and recipes. This jumble of nomenclature can trip up students and newcomers, but anyone used to tracking down data on chemicals grows familiar with cross-referencing IUPAC, CAS, and INCI numbers. It’s all part of the background work that goes into safe handling and proper classification in a crowded laboratory or manufacturing line.

Safety and Operational Standards

Safety stands front and center in every setting, from research labs to processing plants. Propyl butyrate is flammable and needs careful storage away from sparks and open flames. Direct skin contact usually brings minor irritation, though inhaling its vapor in any concentration leads to headaches and dizziness—a lesson learned by anyone stuck prepping large batches without proper hoods. Facilities use local exhaust, PPE, and tight sealing containers to minimize risk. Occupational standards from OSHA, the European Chemicals Agency, and similar groups shape how companies set exposure limits and train workers. People sometimes shrug off safety with familiar-smelling compounds, but even a known ester deserves respect at industrial scales.

Application Areas

Food flavoring likely represents its biggest stage. Propyl butyrate lends balanced, fruity notes to drinks, gums, and confections—its subtle undertone rounds out pineapple and pear flavors in particular. The fragrance world taps into its appeal for body sprays and bath products, with manufacturers counting on its volatility for fast scent release. For a chemist, the solvent-like qualities and hydrophobic nature fit specialized coatings, printing inks, and cleaners. Anyone who’s run an HPLC or a flavor test panel knows how a tiny dose goes a long way. Demand comes from both industrial-scale manufacturing and the tinkering done by research teams exploring new flavor systems or delivery formats.

Research and Development

Research never stops in the world of esters. Teams still look at improving yield, greening up the process, and reducing waste streams. Biocatalysis, as seen in recent literature, excites people aiming for more sustainable production, as enzymes mean less harsh reagents and milder conditions. Shelf stability, migration studies in packaging, and interaction with other food components all serve as growing areas—especially for those concerned with trace migration and long-term storage under variable humidity and temperature. Analytical chemistry pushes for better methods to detect and quantify propyl butyrate in complex matrices, connecting food safety with flavor authenticity. Keeping up with the literature lays out how far one can push the chemistry without stumbling into regulatory or supply problems.

Toxicity Research

Toxicologists give propyl butyrate a close look, particularly for repeated exposure at high levels. Standard animal studies and cell culture assays pointed to low acute toxicity, with regulators approving limited use across many countries. Chronic inhalation and ingestion have set limits, reflecting the precautionary stance common for flavor compounds. Researchers keep tabs on metabolic breakdown and potential allergenicity, supporting ongoing claims that food-grade levels do not create problems for most people. Anyone who’s handled high concentrations in poorly ventilated spaces knows head-splitting discomfort is real, so process engineers respect exposure limits strictly. Assessments also touch on environmental fate, as spills or improper disposal challenge wastewater systems with bioaccumulation risks.

Future Prospects

Propyl butyrate stands at a crossroads shaped by consumer demand, regulatory tightening, and shifts in raw material sourcing. Synthetic biology and fermentation routes spark hope for cleaner, traceable bowls, answering growing calls for “natural” labels and renewable origins. Regulatory landscapes shift as new data emerge about trace allergens or environmental concerns, prompting reformulation or new blends in flavor houses. Automation and process monitoring drive waste down while raising efficiency for producers juggling profit and safety. Scientists and engineers team up, pressing forward for improved process economics and even broader applications, such as in biodegradable plastics or eco-friendly solvents. Judging by the pace of change, propyl butyrate’s next chapter will look very different from its humble beginnings in 19th-century glassware.




What is Propyl Butyrate used for?

The Story Behind That Sweet, Fruity Kick

A lot of folks have never heard of propyl butyrate. If you pick up a bottle of peach soda or a fruit-flavored candy, odds are good you've crossed paths with it. Propyl butyrate carries a strong, pineapple-like aroma. Food scientists tap into that fragrance to liven up bland foods and drinks. I remember inspecting soda ingredients as a teenager—after noticing “natural and artificial flavors” on almost every package. Digging deeper, many of those artificial notes come from small molecules like propyl butyrate.

Everyday Products and Personal Care

Food companies count on ingredients that stick around—no one wants a chewy, fruity gum to lose its taste after two bites. Propyl butyrate gives more staying power to flavors in chewing gum, fruit syrups, and candies. Many modern perfumes and lotions borrow that sweet, tropical scent, and not every fruit-smelling shampoo comes from raw fruit. Chemists design these scents to be stable and consistent, so whatever you grab from the shelf at your local drugstore, you get the same pleasant result.

How Safe Is Propyl Butyrate?

The US Food and Drug Administration and European Food Safety Authority both say it’s safe in small amounts. Every flavor chemical goes through a panel of toxicology tests, some taking years. The testing looks for low-dose use and traces whether it builds up in the body. Most flavor chemicals, including propyl butyrate, move through the body quickly after eating or smelling them. If you trust a big soda company, you’re trusting their food chemists to stick close to safety limits.

Chasing New Uses

Farming and crop protection grab a piece of the pie, too. Scientists working with fruit crops use synthetic flavors like propyl butyrate as attractants for monitoring insects. Traps baited with a sweet, fruity scent help monitor and control flies in orchards. Farmers rely on these signals to catch pests before they ruin the crop. Without easy detection, insect outbreaks can wipe out whole harvests. That scent, which seems whimsical in a candy store, powerfully draws certain bugs—sometimes just as effectively as old bait like fermenting fruit.

The Worth of Knowing What’s Inside

People get uneasy about chemical names in ingredient lists, but recognizing them fosters smarter choices. If you look at the GRAS status (Generally Recognized as Safe) for propyl butyrate, it builds a fuller picture. Nothing replaces moderation—large doses of any flavoring could push past those safety levels. In school health class, I heard warnings about artificial sweeteners, and the message holds up: the dose decides the poison. Knowing where propyl butyrate shows up helps folks decide what to eat or use.

Pushing for Transparency

I see demand rising for full ingredient disclosure, especially in food for kids. That push lets parents, teachers, and anyone curious ask better questions. Maybe labels move beyond “artificial flavors” toward listing each one out, so shoppers know when they pick up a soda with propyl butyrate. Open info helps allergy sufferers and builds trust between brands and buyers. As more people demand to know what's behind product names, companies should keep putting clear facts front and center.

Is Propyl Butyrate safe for consumption?

What is Propyl Butyrate?

Propyl butyrate lands on more ingredient labels these days, mostly for the sweet, fruity hit it brings to candies, drinks, and baked goods. In labs, it appears as a simple ester made from butyric acid and propanol. This stuff gives foods a juicy, apple-peach aroma that flavor experts appreciate. Even though it sounds engineered, traces of similar compounds show up in pineapples and other fruits in nature.

Reviewing the Safety Data

For families and shoppers, tasting new flavors sometimes comes with worry. “Is it safe for my kids?” pops up every time we find a new chemical name on a wrapper. The answer to that relies on both research and regulation. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) reviewed propyl butyrate years back. They didn’t find enough reason to ban or restrict its use at typical levels in food. After that, the Flavor and Extract Manufacturers Association (FEMA) gave it “generally recognized as safe” (GRAS) status for its usual food doses.

My own time in the kitchen and the classroom taught me a lot about food chemistry. At tiny levels, compounds like this often break down into even simpler acids and alcohols during digestion—similar to what a ripe banana or aged cheese provides, just in a more purified package. In terms of toxicology, researchers lean heavily on animal studies and metabolic models. For propyl butyrate, even at levels much higher than any person would eat, there aren’t signs of organ damage or worrisome mutations in DNA tests. That lets food scientists sleep a little easier.

Consumer Concerns Around Chemicals

Even after safety data rolls in, plenty of folks remain concerned about “artificial” sounding ingredients. I see this almost every day working in nutrition. Some people point to allergies or hyperactivity concerns whenever a new preservative or flavoring hits the shelves. But so far, no peer-reviewed studies link propyl butyrate to allergic reactions or behavior changes. It simply gets digested as basic building blocks—nothing fancy by the time it reaches the bloodstream.

Still, I respect the questions. Transparency matters in the modern food world. Many just want clear labeling and truthful information before deciding. I’ve found that honest conversation with consumers pushes companies to keep up with open ingredient lists and accessible safety data. Shoppers want less jargon and more plain language so that no one feels tricked or confused by a list of additives.

Better Food Choices and Solutions

Staying informed pays off here. People feel best when they pick food with ingredient lists that don’t require a chemistry degree. Reading up on the science behind compounds like propyl butyrate offers peace of mind and—if concerns linger—enables smarter choices. Companies could do a better job describing both natural and synthetic sources, especially for families who keep allergies in mind. Regulators should also keep updating databases as new research unfolds, to make sure safety standards match what current science says.

Food never comes risk-free, whether from a field or a lab. With propyl butyrate, real evidence still supports its status as a safe, low-dose flavor enhancer. It’s up to each of us to balance curiosity, taste, and health as we load our plates.

What are the main applications of Propyl Butyrate?

The Chemistry of Everyday Enjoyment

Propyl butyrate barely turns heads in most grocery stores or kitchens, yet it quietly shapes some of our favorite experiences. This colorless liquid brings a fruity, pineapple-like aroma, convincing both food and fragrance makers to reach for it regularly. It works efficiently in small amounts, proving that value doesn’t always come from something loud or famous. As someone who’s spent years around food science labs, it’s easy to recognize the quiet influence propyl butyrate holds on commercial food quality and consumer enjoyment.

Impact on Food Flavors

Baked goods, candies, chewing gum, and many fruit-flavored beverages count on the vibrant scent and taste delivered by propyl butyrate. Food scientists love it for two reasons. First, it creates natural-tasting pineapple and apricot notes that hold up through manufacturing and shelf storage. Second, it helps balance flavors in recipes that use artificial bases, letting them taste closer to real fruit. The flavor industry values stability as much as inventiveness, and propyl butyrate checks both boxes. Even natural fruit juice sometimes relies on just a pinch to deliver a consistent experience bottle after bottle.

Sweetening the Scentscape

This ester doesn’t stick to food. Perfume and household product makers lean on it for its uplifting aroma. It lands in perfumes to build fruity top notes and brings a hint of sweetness to air fresheners, soaps, and cleaning sprays. The goal goes beyond just masking odors; propyl butyrate draws the nose to fresh places, helping people associate home and self-care with pleasant, inviting environments. A good fragrance does more than just cover up—the right compound changes a mood, and propyl butyrate helps with that lift.

Uses Beyond the Obvious

Some don’t realize that animal feed manufacturers and pet care companies also use propyl butyrate. It helps mask the harsher scents of base ingredients, making feed more appealing to animals and less off-putting to the humans who handle it. The ester can encourage consistent eating habits in livestock, supporting animal health and growth. It even has a place in lab work; researchers exploring how animals perceive aromas frequently rely on propyl butyrate to trigger natural responses during experiments.

Safety and Science Matter

All this popularity brings responsibility. Food and fragrance makers need to follow strict safety standards set by agencies like the FDA and EFSA. Both organizations limit usage and require quality checks to ensure no unexpected side effects hit consumers. Even a reliable compound like propyl butyrate demands ongoing study—researchers test for allergies, metabolic byproducts, and how it breaks down in the body and the environment. The flavor and fragrance industries rely on this science to build trust with buyers and end-users. Companies with strong track records of transparency find longer success, and consumers pay attention to how safety gets upheld as much as flavor.

A Path Toward Cleaner Sourcing

Propyl butyrate usually gets produced from chemical reactions between propanol and butyric acid. Green chemistry methods, such as using bio-derived alcohols, now play a growing role in creating these esters. This movement toward renewable sourcing not only draws less from fossil fuels, but it also lets food companies place cleaner, more ethical claims on their finished goods. Responsible supply chains combined with careful use keep propyl butyrate’s reputation strong among both brand owners and everyday shoppers. Real progress always starts with small changes made for better reasons.

What is the chemical formula of Propyl Butyrate?

What’s Behind the Name Propyl Butyrate?

Propyl butyrate brings together two building blocks: propyl alcohol and butyric acid. The chemical formula for propyl butyrate is C7H14O2. That small sequence packs a punch of both science and daily-life impact. You get three carbon atoms from the propyl group and another four from the butyrate side; together, they form a clear liquid that holds a fruity aroma, familiar to anyone who's spent time around flavor labs or read the ingredients in candy or beverages.

A Closer Look at Its Role

Everyone knows the sensation of picking up a piece of fruit and catching that fresh scent. Makers of artificial flavors and fragrances often turn to propyl butyrate to add that extra kick to sweets, perfumes, and some drinks. Its formula, C7H14O2, shapes not just the smell but the way our senses experience a product. In my time experimenting with baking extracts in a home kitchen, the tiniest drop of an ester like propyl butyrate does more than sugar or juice ever could.

Food safety specialists recognize the importance of knowing your chemicals, especially those that end up in what you eat. It goes beyond taste; propyl butyrate, based on what scientific research tells us, leaves little risk when kept within established guidelines. The US Food and Drug Administration marks it as Generally Recognized as Safe. Toxicology reviews back this up, highlighting that the body quickly breaks esters like propyl butyrate down into natural compounds.

Broader Value Beyond the Lab

You run into propyl butyrate even outside the pantry or perfumery. Solvents, coatings, and even some pharmaceutical applications take advantage of the way this ester interacts with other chemicals. Anyone who has ever mixed paints knows the role of small organic molecules in creating just the right consistency and finish. Propyl butyrate’s formula gives it enough flexibility to dissolve substances or disperse pigments, supporting various creative or industrial tasks.

Farmers and environmental scientists also encounter this compound in pest control and testing studies. Traps with specific scents rely on esters, and propyl butyrate helps lure target insects thanks to its low detection threshold for certain species. Nature’s chemistry underpins strategies from orchard management to urban sanitation.

Making Safer and Smarter Choices

Accurate chemical knowledge helps people decide what to bring into their homes and workplaces. Takeaway menus, air fresheners, and hobby kits sometimes contain ingredients with names that sound unfamiliar. By checking the chemical formula—C7H14O2, in this case—consumers and professionals can do quick research or raise questions before using a new product.

Investing in education pays off. Schools that include basic organic chemistry give young people a head start in understanding everyday substances. Crafting basic experiments with safe esters can introduce concepts like volatility, solubility, and sensory science without needing expensive equipment. High-quality science teaching gives students more tools for healthy skepticism and curiosity.

Room for Reflection and Action

Businesses involved in flavors, fragrances, or solvents should stay transparent with ingredient lists. Government agencies and health organizations continue to review safety data, but consumers still need clear labeling to support informed choices. Quality assurance testing ensures that concentrations of esters like propyl butyrate stay within international guidelines, safeguarding both personal health and food integrity.

Anyone handling chemicals should keep up training and always use gloves or masks where needed. Hobbyists, teachers, and workplace managers get better results by taking small steps toward safer chemistry every day.

Does Propyl Butyrate have any side effects or hazards?

Looking at Propyl Butyrate

Propyl butyrate shows up most often in the food and fragrance world. The compound’s fruity aroma lands it in hard candies and perfumes, though it doesn’t sound quite so pleasant on a label. Seeing unfamiliar chemicals on ingredient lists can make some people uneasy, and that’s fair. So it’s worth asking: does propyl butyrate come with health risks or environmental hazards?

Health Effects: What Science Tells Us

Most folks run into propyl butyrate without even realizing it—chewing a stick of gum or eating a processed snack. Research on this substance, tested by organizations that study food safety, generally gives it the green light for ordinary use. Groups like the U.S. Food and Drug Administration and the Joint FAO/WHO Expert Committee on Food Additives have labeled it as “generally recognized as safe” in tiny amounts, such as those used to flavor foods.

Problems tend to crop up at much higher exposures. For workers in chemical plants or folks spending lots of time around concentrated propyl butyrate, irritation to the eyes, skin, and throat can occur. Inhalation can trigger coughing and headaches. This matches patterns seen in similar organic solvents. My own time in a food science lab taught me to avoid even mild solvent fumes—after one long day organizing a chemical cabinet, I left with watery eyes and a scratchy throat, all because the cap on a flavoring agent wasn’t tight.

No evidence shows propyl butyrate causes cancer, birth defects or other long-term problems in humans at the levels found in consumer products. It's wise to remember that “safe in small amounts” doesn’t mean “harmless in any situation.” High concentrations aren’t meant for kitchen or home use.

Accidental Exposure and Safety Measures

In factories and labs, spills happen. If undiluted propyl butyrate hits skin, it stings and can trigger rashes. Breathing in vapors from a large leak can lead to nausea and dizziness. Companies using this chemical keep it locked up for good reason, with protective gear, fume hoods, and spill-kits at the ready. Safety data sheets repeat the same message: keep it off skin, don’t breathe it in, and never drink it.

Some folks react more strongly to chemical smells, even at low levels. I once met a perfume shop worker who always wore gloves and switched out of her work shirt as soon as she got home, since certain fragrance ingredients left her queasy or came home in her hair.

Environmental Concerns

Propyl butyrate biodegrades fairly quickly. If a bottle breaks, soil microbes usually break it down before too long. Problems pop up near water. Fish and other aquatic life can be harmed by large spills. Regulations require responsible companies to store and dispose of flavoring agents well away from drains or waterways.

In small doses, like a drop or two for flavoring, there’s little cause for worry. Large leaks or improper disposal deserve attention and robust cleanup, same as any industrial chemical.

Navigating Daily Choices

Most ordinary folks have little to worry about with propyl butyrate showing up in food labels or perfumes. The same isn’t true for workers who handle barrels or use it to make flavors in factories. Good ventilation, gloves, and safe practices matter. Agencies such as OSHA and EPA spell out safe limits for workplace air and disposal, so workers and neighbors stay protected.

On the consumer side, picking foods or products with shorter ingredient lists can ease anxiety for people sensitive to additives. If you ever notice new skin irritation or headaches around fragrances or cleaning products, note the label and steer clear. There’s no shame in choosing unscented items or less-processed foods if that works better for your body.

Propyl Butyrate
Propyl Butyrate
Propyl Butyrate
Names
Preferred IUPAC name Propyl butanoate
Other names Butyric acid propyl ester
Propyl n-butyrate
n-Propyl butyrate
Pronunciation /ˈproʊpɪl ˈbjuːtɪreɪt/
Identifiers
CAS Number 123-25-1
3D model (JSmol) `JSmolModel__C(=O)OCCC(=O)C(C)CC`
Beilstein Reference 635687
ChEBI CHEBI:86443
ChEMBL CHEMBL3173713
ChemSpider 57006
DrugBank DB16614
ECHA InfoCard 100.006.332
EC Number 203-481-6
Gmelin Reference 14606
KEGG C18617
MeSH D011375
PubChem CID 8022
RTECS number UF9100000
UNII X9V0X9F0R1
UN number UN3272
Properties
Chemical formula C7H14O2
Molar mass 130.18 g/mol
Appearance Colorless to slightly yellow liquid
Odor fruity
Density 0.868 g/mL at 25 °C (lit.)
Solubility in water 1.2 g/L
log P 2.41
Vapor pressure 0.6 mmHg (20°C)
Acidity (pKa) Estimated pKa ≈ 25
Magnetic susceptibility (χ) -7.43e-6
Refractive index (nD) 1.406
Viscosity 2.86 mPa·s
Dipole moment 1.80 D
Thermochemistry
Std molar entropy (S⦵298) 340.7 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -480.8 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -4278.0 kJ/mol
Pharmacology
ATC code A16AX11
Hazards
GHS labelling GHS02, GHS07
Pictograms GHS02,GHS07
Signal word Warning
Hazard statements H226, H315, H319, H335
Precautionary statements Precautionary statements: "P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P235, P501
NFPA 704 (fire diamond) 1-2-0-~
Flash point 71°C
Autoignition temperature 400 °C
Explosive limits 1.1% - 7.1%
Lethal dose or concentration LD50 (oral, rat): 7680 mg/kg
LD50 (median dose) LD50 (median dose): Rat oral 8200 mg/kg
NIOSH SNH17450
PEL (Permissible) PEL: Not established
REL (Recommended) 100
IDLH (Immediate danger) 200 ppm
Related compounds
Related compounds Methyl butyrate
Ethyl butyrate
Isopropyl butyrate
Butyl butyrate
Propyl acetate
Propyl propionate