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Product Name: 11Α,17Α-Dihydroxyprogesterone
Chemical Synonyms: 11α,17α-Dihydroxypregn-4-ene-3,20-dione
CAS Number: 600-64-6
Molecular Formula: C21H30O4
Molecular Weight: 346.46 g/mol
Recommended Uses: Laboratory research, pharmaceutical synthesis
Supplier Details: Refer to sourcing documents, include full address and emergency telephone number for supplier and manufacturer
GHS Classification: Combustible dust, reproductive toxicity category 2
Hazard Statements: May cause harm to unborn child, may impair fertility, causes skin and eye irritation, harmful if swallowed
Signal Word: Warning
Pictograms: Health hazard, irritation
Precautionary Statements: Wear suitable protective clothing, use eye protection, avoid breathing dust, wash thoroughly after handling, obtain special instructions before use, do not handle until all safety precautions have been read and understood
Chemical Name: 11Α,17Α-Dihydroxyprogesterone
Concentration: 98-100%
Impurities/Additives: Trace solvent residues possible from synthesis, typically less than 0.5%
EC Number: 209-012-2
EINECS No.: 209-012-2
Inhalation: Move to fresh air, keep at rest, provide oxygen if breathing is difficult, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin with plenty of soap and water, seek medical help if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek immediate medical advice
Ingestion: Rinse mouth, seek immediate medical advice, do not induce vomiting unless directed by medical personnel
Most Important Symptoms: Irritation, possible endocrine effects, allergic reactions, medical attention required for severe symptoms
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray
Unsuitable Media: High volume water jet, avoid contamination of water sources
Specific Hazards: May emit toxic fumes (carbon oxides) under fire conditions, dusts can form explosive mixtures with air
Protective Equipment: Wear self-contained breathing apparatus, full protective gear
Fire-Fighting Guidance: Stay upwind, evacuate unnecessary personnel, cool containers with water spray
Personal Precautions: Wear personal protective equipment (gloves, goggles, respirators), avoid breathing dust, provide sufficient ventilation
Environmental Precautions: Prevent entry into drains, watercourses or soil
Methods for Cleanup: Sweep up avoiding dust formation, transfer to suitable container for disposal, wash spill site with soap and water
Additional Procedures: Inform appropriate authorities if product has entered environment
Handling: Use outdoors or in well-ventilated area, avoid dust generation, wash hands and face before breaks and after handling, avoid contact with skin, eyes, and clothing
Storage: Store in a cool, dry, well-ventilated place, keep container tightly closed, keep away from heat and open flame, store away from oxidizing agents and foodstuffs
Incompatible Materials: Strong oxidizers, acids
Special Precautions: Segregate from incompatible materials, label containers clearly, restrict access to trained personnel
Engineering Controls: Use fume hood or local exhaust ventilation to minimize airborne dust, install eyewash stations and safety showers in immediate work area
Personal Protective Equipment: Chemical resistant gloves (nitrile, latex), safety goggles or face shield, lab coat or apron, suitable respiratory protection when airborne exposure is possible
Hygiene Measures: Do not eat, drink, or smoke while handling, wash hands thoroughly after handling and before eating or restroom use
Exposure Limit Values: No established occupational exposure limits for 11Α,17Α-Dihydroxyprogesterone, maintain exposure as low as reasonably achievable
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical odor
Melting Point: 182-186 °C
Boiling Point: Not determined, decomposes before boiling
Solubility: Insoluble in water, soluble in methanol, ethanol, dimethyl sulfoxide, chloroform
Specific Gravity: Approx. 1.2 g/cm³
pH: Not applicable
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Kow): Data not available, expect lipophilic behavior
Volatility: Non-volatile under standard conditions
Chemical Stability: Stable under recommended storage conditions
Reactivity: Unreactive with most common materials under normal handling
Conditions to Avoid: High temperatures, open flames, direct sunlight, strong oxidizing conditions
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, other toxic fumes on combustion
Hazardous Reactions: No data on hazardous polymerization under normal conditions
Acute Toxicity: No acute toxicity data available, may cause local irritation if ingested or inhaled
Skin Corrosion/Irritation: Potential irritant on prolonged contact
Serious Eye Damage/Irritation: May cause eye irritation, redness or discomfort
Respiratory Sensitization: May cause respiratory irritation if dusts are inhaled
Germ Cell Mutagenicity: Not enough data for assessment
Reproductive Toxicity: Endocrine-disrupting properties, risk of adverse reproductive effects
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Target Organ Effects: Endocrine system, liver in high exposures, consult safety officer
Ecotoxicity: Toxic to aquatic organisms with possible long-term effects, avoid release into environment
Persistence and Degradability: Not readily biodegradable, expected to persist in soil and water
Bioaccumulative Potential: May bioaccumulate due to lipophilic structure
Mobility in Soil: Low water solubility indicates low mobility
Other Adverse Effects: Effects on reproduction in aquatic organisms cannot be ruled out
Waste Treatment Methods: Dispose in accordance with local, regional, national, and international regulations
Disposal of Product: Incineration preferred in chemical waste facility, do not dispose in regular trash or wastewater
Disposal of Packaging: Triple rinse containers, destroy to prevent reuse, dispose as hazardous chemical waste
Special Precautions: Prevent atmospheric contamination, minimize handling by untrained personnel
UN Number: Not regulated as dangerous good under ADR, RID, IATA, IMDG
Proper Shipping Name: Chemical substance, not otherwise specified
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: Avoid release during transport, especially to surface waters
Special Precautions: Secure containers against movement, shield from heat, handle with gloves and goggles at all distribution points
Safety, Health and Environmental Regulations: Subject to chemical safety assessment under REACH, potentially classified under US TSCA, listed under EINECS/ELINCS
Worker Protection: Comply with OSHA Hazard Communication Standard (29 CFR 1910.1200), require Safety Data Sheet availability
Labelling Requirements: GHS-compliant labels needed in all workplaces, include pictograms and signal words
Other Regulations: May be subject to pharmaceutical regulations, controlled substance legislation applies in some areas
Inventory Status: Listed on major international chemical inventories (TSCA, DSL, EINECS)
