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MSDS for Piracetam

Identification

Product Name: Piracetam
Chemical Name: 2-oxo-1-pyrrolidineacetamide
Synonyms: Pyrrolidone acetamide, Nootropil
CAS Number: 7491-74-9
Recommended Use: Pharmaceutical ingredient (cognitive enhancer), research chemical
Supplier: Research chemical supplier, pharmaceutical distributor
Contact Information: Emergency phone number and company address listed on shipping documents and invoice

Hazard Identification

Classification: Not classified as hazardous under GHS criteria in many regions
Signal Word: None
Hazard Statements: May cause mild skin or eye irritation in sensitive individuals; large doses can result in gastrointestinal discomfort, ataxia, agitation, or sleep disturbances
Pictograms: None designated
Precautionary Statements: Avoid inhalation, ingestion, and unnecessary contact with skin
Target Organs: Central nervous system
Symptoms of Overexposure: Drowsiness, nervousness, weight gain, diarrhea, fatigue

Composition / Information on Ingredients

Chemical Identity: Piracetam
Purity: ≥98%
Impurities/Additives: Less than 2%, typically related process byproducts
Molecular Formula: C6H10N2O2
Molecular Weight: 142.16 g/mol

First Aid Measures

Inhalation: Move to fresh air, monitor for respiratory distress; provide oxygen if breathing becomes difficult
Skin Contact: Wash immediately with generous amounts of water and soap; remove affected clothing
Eye Contact: Rinse cautiously with clean, running water for at least 15 minutes; avoid rubbing
Ingestion: Rinse mouth with water; seek medical attention for persistent effects, do not induce vomiting without instructions
Most Important Symptoms: May include gastrointestinal upset, agitation, or headache in rare cases
Notes to Physician: Treat symptomatically, monitor vital signs and possible allergic response

Fire-Fighting Measures

Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide, water spray
Unsuitable Media: None reported for this compound
Hazards from Combustion: Emits nitrogen oxides, carbon monoxide, carbon dioxide when burned
Protective Equipment: Self-contained breathing apparatus, full protective gear; avoid inhalation of combustion fumes
Special Procedures: Use standard firefighting techniques; contain runoff to prevent environmental impact

Accidental Release Measures

Personal Protection: Use gloves, goggles, and suitable lab coat or dust mask
Spill Response: Sweep up using non-sparking tools, avoid dust generation; transfer to marked waste containers
Environmental Precautions: Prevent release to waterways or soil
Cleanup: Rinse area with water following removal of bulk material, ventilate

Handling and Storage

Handling: Work in well-ventilated areas, avoid creating or breathing dust, wear protective equipment
Storage Conditions: Store in tightly closed container, keep in cool, dry, well-ventilated location, away from incompatible materials
Incompatibles: Strong oxidizers, strong acids
Specific Recommendations: Label containers clearly, avoid unnecessary handling, practice good hygiene

Exposure Controls and Personal Protection

Engineering Controls: Use fume hood or adequate local exhaust
Personal Protective Equipment: Safety goggles, latex or nitrile gloves, lab coat
Respiratory Protection: Use dust mask or respirator compatible with chemical dusts if airborne particulates exceed safe limits
Hygiene Measures: Wash hands thoroughly after handling, prohibit eating, drinking, or smoking in work area
Exposure Limits: No occupational exposure limits set by OSHA, ACGIH, or NIOSH at this time

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Nearly odorless
pH: 6.0–7.5 (10% solution in water)
Melting Point: 151–152°C
Boiling Point: Data not established (decomposes before boiling)
Flash Point: Data not established
Solubility: Soluble in water, ethanol; practically insoluble in chloroform, ether
Vapor Pressure: Negligible at room temperature
Density: Approximately 1.2 g/cm³
Partition Coefficient (log Kow): −1.8

Stability and Reactivity

Chemical Stability: Stable under normal handling conditions, avoid high temperatures and moisture
Reactive with: Strong oxidizers, strong acids
Conditions to Avoid: Significant heat, open flame, contact with incompatible chemicals
Hazardous Decomposition: Carbon oxides, nitrogen oxides on combustion
Polymerization: Will not occur

Toxicological Information

Acute Toxicity: Low acute toxicity; estimated LD50 (oral, rat) above 5,000 mg/kg
Chronic Effects: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in available studies
Irritation: May cause mild skin and eye irritation in sensitive individuals
Sensitization: Not expected based on available data
Symptoms: High doses in clinical setting linked to anxiety, insomnia, gastrointestinal upset, rarely allergic reactions

Ecological Information

Aquatic Toxicity: No data on ecotoxicity; not expected to bioaccumulate or persist
Mobility in Soil: Expected to exhibit high water solubility and moderate leaching potential
Persistence and Degradability: Likely to degrade in environment, but specific data limited
Bioaccumulative Potential: Low, based on log Kow
Other Harmful Effects: Discharge into waterways may impact aquatic organisms at high concentrations

Disposal Considerations

Disposal Methods: Dispose according to local, regional, and national regulations for non-hazardous organic chemical waste
Packaging Disposal: Triple rinse and dispose of empty packaging as solid waste or per local policies
Precautions: Do not allow to enter drains, water courses, or soil

Transport Information

UN Number: Not regulated as a dangerous good
Transport Hazard Class: Not classified
Packing Group: Not assigned
Labels: None required
Transport Precautions: Ship in tightly sealed original containers, avoid physical damage during transit
Regulations: Compliant with IATA, IMDG, DOT in absence of hazardous classification

Regulatory Information

Global Inventory: Not listed under major chemical inventories as hazardous
TSCA: Not subject to reporting or restriction
REACH: May be exempt as pharmaceutical intermediate
Canada DSL/NDSL: Not listed
California Proposition 65: Not listed as a known carcinogen or reproductive toxin
Workplace Classification: Not regulated as hazardous chemical in most regions