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Product Name: Piperacillin Sodium
Other Names: Piperacillin Disodium Salt, CAS RN: 59703-84-3
Recommended Use: Antibiotic for bacterial infection treatment
Manufacturer/Supplier: Pharmaceutical manufacturers specializing in antibiotics
Emergency Contact: Listed on package insert or company website
Address: Facility address found on package or shipment
Telephone Number: Manufacturer’s phone provided on shipment
Email: Quality or safety office email of the supplier
GHS Classification: Eye irritation (Category 2A), Skin sensitization (Category 1), Respiratory sensitization (Category 1), Acute oral toxicity (Category 4)
Signal Word: Warning
Hazard Statements: May cause respiratory irritation, may cause allergic or asthmatic symptoms, can cause eye irritation, harmful if swallowed
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use personal protective equipment as required, seek medical attention for symptoms after exposure
Chemical Name: Piperacillin Sodium
Chemical Formula: C23H26N5NaO7S
EC Number: 260-937-8
Concentration: 100% unless formulated as drug product
Impurities: Trace manufacturing residuals possible
Synonyms: Disodium (2S,5R,6R)-6-[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Inhalation: Move exposed person to fresh air, allow rest in semi-upright position, seek medical assistance for persistent cough or respiratory distress
Skin Contact: Remove contaminated clothing, wash skin with soap and water for at least 15 minutes, seek medical advice for persistent symptoms or irritation
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present and easy to do, seek ophthalmologic evaluation if discomfort persists
Ingestion: Rinse mouth immediately, give water to dilute if conscious, do not induce vomiting, seek medical advice or call poison control
Medical Attention: Symptomatic support, monitor for allergic responses or anaphylaxis, treat respiratory or cardiac complications as needed
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam as needed for surrounding fire
Specific Hazards: Decomposition may generate irritating gases such as oxides of nitrogen, sulfur, and sodium
Hazardous Combustion Products: Sulfur oxides, nitrogen oxides, carbon monoxide, carbon dioxide, sodium oxides
Protective Equipment: Firefighters wear self-contained breathing apparatus, full turnout gear for dust or vapor exposure
Firefighting Advice: Prevent contaminated runoff from entering drains, apply firefighting efforts from a safe distance due to potential airborne dusts
Personal Precautions: Evacuate unprotected personnel, avoid generating dust, ensure adequate ventilation, wear recommended personal protective equipment
Environmental Precautions: Prevent product from entering drains, surface water, or soil
Cleanup Methods: Scoop up gently and collect spillage with non-reactive absorbent, sweep or vacuum using filter-equipped industrial vacuum, dispose in a tightly closed container for regulated disposal
Decontamination: Clean surface with water and detergent after removal; ventilate area until all residues are cleared
Notification: Notify proper authorities in case of large spills or if runoff enters environmental waterways
Handling: Avoid contact with eyes, skin, and clothing, prevent inhalation of dust, wash hands after use, avoid eating or drinking in handling area, handle in a well-ventilated environment
Technical Measures: Use only in locations with adequate ventilation or engineering controls, ground and bond containers when dispensing large amounts
Storage Conditions: Store tightly closed in original container, keep in a dry, cool, well-ventilated place, protect from moisture and light
Incompatible Materials: Strong acids, oxidizing agents, basis solutions above neutral pH
Storage Temperature: 15–25°C recommended for stability; avoid freezing liquid forms
Occupational Exposure Limit: No established OSHA or ACGIH TLV for Piperacillin Sodium
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne concentrations below recommended exposure limits
Personal Protection: Wear protective gloves (nitrile or latex), safety goggles or face shield, laboratory coat or coveralls, use NIOSH-approved dust respirator if dust generation is expected
Hygiene Measures: Wash hands and forearms thoroughly after handling, do not reuse contaminated work clothing, avoid incidental oral or dermal exposure
Environmental Exposure Controls: Prevent release into public water systems, maintain spill control procedures
Physical State: Powder or lyophilized cake
Color: White to off-white
Odor: Odorless or slight medicinal smell
pH: 5.0–7.0 (10% solution)
Melting Point/Range: Not available (decomposes on heating)
Boiling Point: Not applicable for solid
Flash Point: Not available
Solubility: Freely soluble in water
Partition Coefficient (log Kow): -2.85 (estimated)
Vapor Pressure: Not applicable
Bulk Density: Approximately 0.3–0.5 g/cm³
Chemical Stability: Stable under normal conditions of storage and use, degrades above 40°C
Reactivity: May react with strong oxidizing agents
Hazardous Reactions: No dangerous reactions known under normal conditions
Conditions to Avoid: Excessive heat, humidity, exposure to air or light
Incompatible Materials: Acidic or basic compounds, oxidizers
Hazardous Decomposition: Nitrogen oxides, carbon monoxide, carbon dioxide, sulfur oxides, sodium oxides on combustion or thermal decomposition
Acute Toxicity (Oral): LD50 (rat) > 5000 mg/kg
Skin Corrosion: Not corrosive; can cause mild irritation in sensitive individuals
Eye Damage/Irritation: May cause redness, tearing, discomfort
Respiratory or Skin Sensitization: Can cause allergic reactions in sensitized populations, documented asthmatic and hypersensitivity type reactions
Germ Cell Mutagenicity: No significant data available, not classified
Carcinogenicity: Not listed by IARC, NTP, or OSHA
Reproductive Toxicity: Limited animal studies, no known teratogenicity at exposure levels used in humans
Target Organ Effects: Hypersensitivity, blood dyscrasias, possible renal function changes in overdose
Aquatic Toxicity: Data limited, not considered highly toxic to aquatic organisms at spill concentrations
Persistence and Degradability: Expected to degrade in sewage and most natural environments; hydrolyzes in water over time
Bioaccumulative Potential: Not expected to accumulate significantly in aquatic organisms
Mobility in Soil: Water solubility suggests high mobility in aquatic systems, potential groundwater contamination if not treated
Other Adverse Effects: Antibiotic activity can disrupt microbial populations in water and soil, may promote resistance if released in significant quantities
Waste Treatment Methods: Dispose through licensed chemical waste contractor, incinerate in compliance with local and national regulations
Product Disposal: Treat as hazardous pharmaceutical waste, do not discharge to sewer or open environment
Container Disposal: Triple rinse and dispose as hazardous waste or, if allowed, via thermal destruction
Environmental Precautions: Avoid unintentional release, include in chemical waste logs
Disposal Regulations: Align with EPA, WHO, and local environmental authority protocols for antibiotic residues
UN Number: Not regulated under UN Recommendations for the Transport of Dangerous Goods
Proper Shipping Name: Not classified as hazardous for transport
Transport Hazard Class(es): Not assigned
Packing Group: Not assigned
Environmental Hazards: Not designated a marine pollutant
Special Precautions: Ship in well-sealed, labeled packaging, store away from moisture or damp sources in transit
OSHA Status: Not listed as a hazardous substance
TSCA Status: Not subject to TSCA reporting; specifically exempted as a pharmaceutical
SARA Title III: Not listed in SARA 302, 304, or 313
FDA Regulation: Approved for medical application under prescription, subject to FDA labeling requirements
State Regulations: No unique state right-to-know notifications
REACH/CLP Status (EU): Registered as a pharmaceutical, subject to occupational safety risk control
Other International Regulations: Listed in national pharmacopoeias, subject to medical and workplace safety legislation globally
