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Product Name: Phloretin
Chemical Name: 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
CAS Number: 60-82-2
Molecular Formula: C15H14O5
Molecular Weight: 274.27 g/mol
Synonyms: Dihydro-4,2',4',6'-tetrahydroxychalcone
Recommended Use: Antioxidant in cosmetic and nutraceutical preparations
Supplier Information: Manufacturer’s or distributor’s contact details with address, phone number, and email
Emergency Telephone Number: Number for chemical emergencies or poison control
Classification: Not classified as hazardous under GHS
Label Elements: No pictogram, no signal word, no standardized hazard statement for this compound
Hazard Statements: Dust may cause respiratory irritation, skin contact may cause mild irritation, ingestion could cause discomfort
Precautionary Statements: Avoid breathing dust, work in well-ventilated space, wear gloves and eye protection, keep container tightly closed
Other Hazards: Product can form combustible dust concentrations in air, contact with strong oxidizing agents could increase hazard risk
Chemical Identity: Phloretin
Purity: Greater than 98%
CAS Number: 60-82-2
Impurities: Trace solvent residues below 0.5%
Additives: No additives, stabilizers, or carriers present
Inhalation: Move exposed person to fresh air, seek medical attention if respiratory symptoms develop
Skin Contact: Wash area with soap and water, remove contaminated clothing, consult medical attention for irritation or rash
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, continue rinsing, seek medical help for persistent redness or pain
Ingestion: Rinse mouth, seek medical advice if feeling unwell, do not induce vomiting unless advised by medical personnel
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Unsuitable Media: Do not use high-volume water jets
Special Hazards: May produce carbon oxides and toxic fumes during combustion
Advice for Firefighters: Wear self-contained breathing apparatus and protective clothing
Explosion Hazard: Dusts in air can form explosive mixtures and ignite under certain conditions
Other Information: Remove containers from fire area if safe to do so, avoid inhalation of combustion products
Personal Precautions: Avoid breathing dust, ventilate area, wear proper protective equipment including gloves and mask
Environmental Precautions: Prevent entry into drains, watercourses, or soil
Methods for Cleanup: Sweep or vacuum up material without generating dust, place residue in properly labeled container for disposal, wash area with water and detergent after removal
Special Guidance: Use non-sparking tools to handle or clean up spilled material
Handling: Use local exhaust or general ventilation, minimize dust generation, avoid contact with skin, eyes, and clothing, wear personal protection
Storage: Store in cool, dry, and well-ventilated place away from direct sunlight and incompatible substances, keep container tightly sealed
Incompatibilities: Avoid strong oxidizing agents and acids
Protective Measures: Ensure packages are clearly labeled and secure from tipping or damage
Engineering Controls: Use adequate ventilation, especially in confined or enclosed areas
Eye Protection: Chemical safety goggles or side-shield safety glasses
Skin Protection: Protective gloves such as nitrile or neoprene, laboratory coat or apron
Respiratory Protection: Dust mask or respirator in case of inadequate ventilation
Other Protective Equipment: Eyewash station and safety shower easily accessible in the work area
Exposure Limits: No established regulatory occupational limits for phloretin, practice general dust exposure control
Appearance: Off-white to light yellow powder
Odor: Odorless
pH: Not applicable in solid state, slightly acidic in solution
Melting Point: 264–267 °C
Boiling Point: Decomposes before boiling
Solubility: Poorly soluble in water, soluble in ethanol and DMSO
Density: Approximately 1.4 g/cm3
Vapor Pressure: Not significant at ambient conditions
Partition Coefficient: log Kow ~2.2
Flash Point: Not flammable in standard laboratory use
Auto-Ignition Temperature: No data available
Explosive Properties: Dust can be an explosion hazard in air
Other Characteristics: Stable under recommended conditions, non-volatile
Chemical Stability: Stable under normal handling and storage conditions
Thermal Decomposition: May release carbon monoxide, carbon dioxide, phenolic compounds at temperatures above 250 °C
Reactivity: Reacts strongly with oxidizing materials
Hazardous Reactions: No known hazardous polymerization
Incompatible Materials: Strong acids, strong bases, oxidizers
Conditions to Avoid: High temperatures, open flames, and direct sunlight
Acute Toxicity: Oral LD50 in rats approximately 2,500 mg/kg (literature); lower toxicity in humans expected at typical exposures
Skin Irritation: May cause mild irritation on prolonged exposure
Eye Damage: Dust can cause transient mechanical irritation
Respiratory Sensitization: No data available, dust may irritate respiratory tract
Chronic Effects: No long-term adverse effects observed in animal models at relevant doses
Carcinogenicity: Not classified as a carcinogen by IARC, ACGIH, NTP, or OSHA
Mutagenicity: No evidence of mutagenicity reported in standard in vitro tests
Reproductive Toxicity: No adverse reproductive or developmental effects observed in animal studies
Target Organ Effects: Data insufficient for target organ specificity
Ecotoxicity: Low acute toxicity toward aquatic organisms based on structural analog data
Persistence and Degradability: Expected to undergo slow biodegradation in environment
Bioaccumulative Potential: Moderate potential, log Kow suggests some accumulation in exposed organisms
Mobility in Soil: Limited mobility due to low water solubility
Other Adverse Effects: Not known to disrupt hormonal or biochemical processes in wildlife, always consider precaution with discharge to environment
Waste Disposal Methods: Collect and place in labeled, sealed containers for chemical waste disposal in accordance with local, regional, and national regulations
Incineration: Permitted in suitable facility; do not dispose of untreated material in municipal waste streams
Container Disposal: Triple-rinse and dispose of containers as hazardous waste
Precautions: Avoid release to the environment, do not flush to sewer, observe all appropriate federal, state, local, and international regulations
UN Number: Not regulated as dangerous goods by air (IATA), sea (IMDG), or land (ADR/RID)
Proper Shipping Name: Not classified as hazardous, ship as laboratory chemical or research compound
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions: Avoid generation of dust during transport, secure packaging to prevent accidental release
OSHA Status: Not regulated as a hazardous chemical
TSCA Inventory: Listed
SARA Title III: Not subject to reporting requirements under Sections 302, 304, 311, 312, 313
California Proposition 65: Not listed as a chemical known to cause cancer or reproductive toxicity
WHMIS Classification (Canada): Not a controlled product
REACH Status: Manufactured in compliance for research and development, commercial uses subject to notification
Other International Regulations: Local workplace and environmental safety policies apply to all handling, storage, and disposal
Labeling: Proper hazard and precaution labels needed if containerized or repackaged for downstream commercial use
