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Product Name: Pazufloxacin Mesylate
Chemical Formula: C16H15FN4O4·CH4O3S
CAS Number: 110639-42-0
Synonyms: Pazucross, Pazufloxacin Hydrochloride Methylsulfonate Salt
Intended Use: Used as an antibacterial agent, primarily for infections caused by Gram-negative bacteria
Supplier: Pharmaceutical manufacturing companies and research suppliers
Emergency Contact: Refer to local regulatory guidelines for emergency numbers
Classification: Hazardous to human health and aquatic environment
Hazard Statements: May cause eye and skin irritation, inhalation of dust may cause respiratory discomfort, ingestion may provoke gastrointestinal disturbances
Signal Word: Warning
Pictograms: Exclamation Mark, Health Hazard, Environmental Hazard
Routes of Exposure: Skin, eyes, inhalation, ingestion
Chronic Effects: Long-term exposure may contribute to organ damage, especially with improper handling
Substance: Pazufloxacin Mesylate
Active Ingredient: Pazufloxacin Mesylate around 99% purity
Impurities: Trace pharmaceutical solvents, less than 1% (content varies by manufacturer)
Other Components: No significant additives or stabilizers intentionally present
Molecular Weight: 442.38 g/mol (base compound)
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, seek medical attention if irritation persists
Skin Contact: Wash affected area with soap and water, remove contaminated clothing, consult physician for persistent symptoms
Inhalation: Move person to fresh air, provide oxygen or artificial respiration if necessary, contact medical personnel
Ingestion: Rinse mouth, do not induce vomiting, seek professional medical help promptly
Critical Symptoms: Burning in eyes, trouble breathing, skin redness, abdominal pain
Advice for Responders: Use gloves and avoid exposure during rescue
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, or water spray
Unsuitable Extinguishing Media: High-pressure water streams may scatter dust
Hazardous Combustion Products: Toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, hydrogen fluoride
Special Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Fire/Explosion Hazards: Combustible dust can form in air, potential for fire under severe conditions
Safety Measures: Avoid inhaling combustion products or direct contact with residues
Personal Precautions: Evacuate unnecessary personnel, wear protective gloves, goggles, and respirator
Environmental Precautions: Prevent entry into waterways, soil, or drains
Containment Methods: Sweep material up without generating dust, use tools safe for hazardous substances
Clean-Up Method: Place in properly labeled, sealed containers for disposal
Decontamination: Wash contaminated area thoroughly with water and detergent
Disposal of Material: Follow hazardous waste protocols specific to pharmaceuticals
Handling: Avoid formation and inhalation of dust, use with adequate ventilation, wear appropriate protective clothing
Preventive Measures: Handle in closed system or equipped hood, minimize spills and contact
Hygiene Practices: Wash hands after handling, avoid eating, drinking, or smoking near area
Storage Conditions: Keep container tightly closed, store at controlled room temperature (15–25°C), away from moisture, heat, and light
Incompatible Materials: Strong oxidizers, strong bases, acids
Storage Precaution: Segregate from food and incompatible substances
Engineering Controls: Use fume hood or well-ventilated area
Respiratory Protection: NIOSH-approved respirator in absence of adequate ventilation
Eye Protection: Safety goggles
Skin Protection: Chemical-resistant gloves, lab coat, long sleeves
Exposure Limits: No ACGIH or OSHA exposure limits established; minimize exposure as for all pharmaceuticals
Other Controls: Eyewash stations and safety showers near handling locations
Appearance: Off-white to pale yellow crystalline powder
Odor: Odorless or faint chemical smell
Melting Point: 234–240°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Soluble in water, dimethyl sulfoxide; slightly soluble in methanol, ethanol
pH (aqueous solution): Between 4.0-5.5
Density: 1.5–1.6 g/cm³
Partition Coefficient: Data not readily available
Vapor Pressure: Not significant at standard temperature
Flammability: Doesn’t ignite easily under normal use conditions
Chemical Stability: Stable under recommended storage conditions
Reactivity: Low risk under normal lab or industrial settings
Possible Reactions: May react with strong oxidants and acids; risk of degradation with strong bases or heat
Decomposition Products: Releases CO, CO2, NOx, HF, SOx upon combustion or decomposition
Hazardous Polymerization: Will not occur
Conditions to Avoid: Prolonged exposure to moisture, extreme temperatures, incompatible chemicals
Acute Toxicity (Oral, Rat): Limited data, estimated LD50 exceeds 2000 mg/kg
Acute Toxicity (Dermal, Rabbit): No reliable data, handle as potentially hazardous
Skin Irritation: May cause mild local irritation
Eye Irritation: Potential for redness, tearing, and discomfort
Inhalation Risk: Dust inhalation can cause respiratory irritation, coughing, shortness of breath
Sensitization: Allergic reactions possible on repeated contact
Chronic Exposure: Animal studies point to possible liver or kidney effects at high doses
Carcinogenicity/Mutagenicity: No conclusive long-term studies in humans
Reproductive Toxicity: No known major reproductive risks in humans at therapeutic doses
Aquatic Toxicity: Toxic to aquatic organisms, risk of long-term adverse effects in water environment
Persistence and Degradability: Degradation may be slow; pharmaceutical residues detected in some aquatic environments
Bioaccumulation: Low to moderate potential based on structure and solubility
Soil Mobility: Soluble enough to migrate, especially if released continuously
Other Effects: Antibiotic residues may disrupt natural microbial communities
Precaution: Do not dispose in natural water sources or via municipal sewage without treatment
Waste Disposal Methods: Dispose as hazardous pharmaceutical waste, incinerate or use approved chemical disposal company
Contaminated Packaging: Treat empty containers as hazardous, triple-rinse and send to chemical waste management facility
Do Not: Release into drains, soil, or natural bodies of water
Additional Guidance: Consult local, regional, and national regulations for pharmaceutical waste disposal procedures
UN Number: Not assigned for pharmaceuticals in small quantities
UN Proper Shipping Name: Pharmaceutical product, not regulated for ground transport in many countries
Transport Hazard Class: Not classified as hazardous for transport under ADR, RID, IMDG, IATA codes
Packing Group: Not applicable
Special Precautions: Ship in tightly closed original container, protect from moisture and direct sunlight
Environmental Hazards: Large spills may pose environmental risk, use secondary containment
OSHA: Not specifically listed as hazardous under US OSHA regulations, general pharmaceutical safety guidance applies
TSCA: Not listed in the US EPA Toxic Substances Control Act inventory
European Union Classification: Hazard classification under CLP Regulation required for bulk handling
WHMIS: Not classified as controlled under Canadian WHMIS
Other Regulations: Subject to stringent handling and disposal guidelines under national laws for pharmaceuticals
Labeling Requirement: Clearly indicate product name, hazard statements, and emergency contact on all containers
Document Retention: Keep SDS and handling logs available to relevant personnel and regulatory bodies
