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Product Name: Oryzanol
Chemical Name: Gamma-Oryzanol
Synonyms: 4-Hydroxy-3-methoxycinnamic acid (ester with triterpene alcohols and phytosterols)
CAS Number: 11042-64-1
Recommended Use: Ingredient in nutraceuticals, health supplements, cosmetics
Supplier: Information available on commercial invoice or packaging
Contact Information: Emergency contact listed on packaging, includes emergency response numbers for medical advice and chemical spill assistance
GHS Classification: Not classified as hazardous according to GHS standards
Primary Routes of Exposure: Inhalation, skin, eye contact, ingestion
Hazard Symbols: No pictogram required for normal use
Signal Word: No signal word assigned
Hazard Statements: Mild irritation possible with eye or skin contact; dust may irritate respiratory tract
Precautionary Statements: Handle with personal protection, avoid inhaling powder or dust, avoid eye contact, wash thoroughly after handling
Chemical Composition: Oryzanol mixture (triterpene ferulates and phytosterols), major component around 98%-100% purity
Impurities and Stabilizing Additives: Minor amounts of plant-derived materials, no stabilizers present
Ingredient Details: Gamma-Oryzanol sources from rice bran, includes cycloartenyl ferulate, 24-methylene cycloartanyl ferulate, campesteryl ferulate
Eye Contact: Rinse with plenty of clean water for several minutes, remove contact lenses if present and easy to do, seek medical attention for irritation
Skin Contact: Wash with soap and warm water, seek attention if rash or irritation continues
Inhalation: Move person to fresh air, keep at rest, seek medical assistance if persistent cough or breathing difficulty occurs
Ingestion: Rinse mouth with water, do not induce vomiting, consult a healthcare professional for large quantities or if symptoms of distress develop
Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, foam, or water spray for small fires
Unsuitable Extinguishing Media: Do not use water jets directly on the burning powder
Specific Hazards: Dust may form explosive mixture with air; possible production of toxic fumes (carbon monoxide, carbon dioxide) in fire
Protective Equipment: Wear full protective gear and self-contained breathing apparatus; control run-off to prevent environmental contamination
Firefighting Instructions: Evacuate unnecessary personnel, cool surrounding containers with water spray if safe
Personal Precautions: Wear dust mask, safety goggles, protective gloves
Environmental Precautions: Prevent entry into waterways, drains, and soil
Methods of Cleanup: Sweep or vacuum powder without raising dust, collect in closed container for proper disposal, ventilate area well; wipe remaining material with damp cloth if possible
Handling: Use adequate ventilation, wear recommended personal protective equipment, avoid generating dust clouds, avoid contact with eyes and skin
Storage: Keep in tightly closed container, store in cool, dry, ventilated area, protect from light, heat, and moisture, segregate from strong oxidizers and acids, keep away from incompatible materials
Special Practices: Maintain good housekeeping in storage and work areas, avoid eating, drinking, or smoking while handling the material
Recommended Exposure Limits: No established occupational exposure limit for Oryzanol
Engineering Controls: Use local exhaust ventilation if dust is generated, handle in well ventilated area
Personal Protective Equipment: Safety glasses or goggles for eye protection, gloves for skin protection, dust mask or respirator for high-dust conditions, lab coat or protective outer clothing
Hygiene Measures: Wash hands after handling, remove contaminated clothing before entering eating areas
Physical State: Powder or fine crystalline solid
Color: Off-white to pale yellow
Odor: Very mild, characteristic
Melting Point: 137–142 °C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, freely soluble in ethanol, ethyl acetate, vegetable oils
Density: Approximately 1.05 g/cm³ (20°C)
pH: Not applicable (insoluble in water)
Vapor Pressure: Not applicable
Partition Coefficient (log Pow): Approximately 10 (highly lipophilic)
Flash Point: Not determined, expected to be high due to non-volatile nature
Chemical Stability: Stable under recommended storage conditions
Reactivity: Inert under normal processing and storage
Conditions to Avoid: High temperatures, flame, strong oxidizers, prolonged exposure to moisture
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, possibly irritant organic compounds on combustion
Acute Toxicity: Oral LD50 (rat) estimated >5000 mg/kg (very low acute toxicity reported in published data)
Skin Corrosion/Irritation: Not irritating to skin on brief contact
Eye Damage/Irritation: Mild irritation possible from dust
Respiratory Sensitization: Dust may cause mechanical irritation
Germ Cell Mutagenicity: No evidence from available data
Carcinogenicity: No classification as carcinogen; animal studies negative for tumor promotion
Reproductive Toxicity: No reported reproductive or developmental toxicity at typical exposure levels
Specific Target Organ Toxicity: No specific organ toxicity known
Potential Health Effects: Ingestion in reasonable quantities considered non-harmful based on nutritional uses, continuous exposure to large amounts not recommended
Ecotoxicity: Not expected to pose risk in aquatic environments; low water solubility and biodegradability reduce environmental persistence
Persistence and Degradability: Breaks down under environmental conditions; derived from natural plant material
Bioaccumulative Potential: Low; partitioning to sediment predicted
Mobility in Soil: Low mobility due to insolubility in water
Other Adverse Effects: No known adverse effects documented in environmental studies
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations for non-hazardous organic chemicals
Disposal of Packaging: Contaminated packaging must be emptied and disposed at approved waste sites
Special Precautions: Do not release to the environment, avoid generation of dust during disposal operations
Recycling: Container recycling possible once thoroughly cleaned
UN Number: Not regulated as a dangerous good for transport
UN Proper Shipping Name: Not classified as hazardous
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Special Transport Precautions: Protect containers from physical damage, moisture, and extreme heat, keep containers upright
Environmental Hazards: Not a marine pollutant
Transport Labels: No hazard labels required
Safety, Health, and Environmental Regulations: Not listed as a hazardous substance according to OSHA, TSCA, REACH, or similar regulatory body
Other Regulations: Ingredient permitted in dietary supplements by FDA, listed in food and pharmaceutical compendia in many countries
Labeling Requirements: Not classified as hazardous, general workplace labeling applies
Inventory Status: Present on chemical inventories such as TSCA, EINECS, DSL
Restrictions: Use in accordance with relevant product specification and local regulations; no specific national or international restrictions for use as a food, cosmetic, or supplement ingredient at recommended doses
