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Product Name: Niclosamide Anhydrous
Common Name: Niclosamide
Chemical Family: Salicylanilide Derivative
Recommended Use: Pesticide (Molluscicide, Anthelmintic)
Manufacturer: Refer to supplier details on shipment documents
Emergency Contact: National chemical emergency hotline or poison control center
Synonyms: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
CAS Number: 50-65-7
GHS Classification: Acute toxicity (oral), Category 4; Acute toxicity (inhalation), Category 4; Acute toxicity (dermal), Category 4; Eye irritation, Category 2A; Skin irritation, Category 2; Aquatic acute, Category 1
Signal Word: Warning
Hazard Statements: Harmful if swallowed, in contact with skin, or if inhaled. Causes skin and eye irritation. Very toxic to aquatic life.
Pictograms: Exclamation mark, Environment
Precautionary Statements: Avoid breathing dust or vapors. Wear protective gloves and eye protection. Do not let product reach waterways. Wash hands thoroughly after handling.
Chemical Name: Niclosamide Anhydrous
Purity: ≥ 98%
Active Ingredient: Niclosamide (C13H8Cl2N2O4)
Impurities: Minor byproducts traceable to manufacturing; content varies
Other Components: Non-active diluents and anti-caking agents possible, contents proprietary to suppliers
Inhalation: Move person to fresh air. If not breathing, provide artificial respiration. Seek medical attention.
Skin Contact: Remove contaminated clothing. Rinse affected area with soap and plenty of water. If irritation persists, get medical help.
Eye Contact: Rinse eyes gently with water for at least 15 minutes. Remove contact lenses if present. Medical attention is required for persistent symptoms.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting unless directed by medical personnel. Obtain medical advice immediately.
Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide, or water spray for small fires
Unsuitable Media: Solid streams of water may spread product
Special Hazards: Combustion may produce toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides and hydrogen chloride
Protective Equipment: Firefighters require self-contained breathing apparatus and standard protective gear. Keep containers cool by spraying water if exposed to fire.
Personal Precautions: Wear chemical-resistant gloves, long sleeves, goggles and an approved respirator during cleanup.
Environmental Precautions: Prevent runoff into drains, sewers, or waterways.
Cleanup Methods: Sweep up and place in a suitable closed container for proper disposal. Avoid dust formation, ventilate area. Clean contaminated surface with water and detergent, collect washings for disposal.
Handling: Maintain adequate ventilation. Avoid contact with skin, eyes and clothing. Use only with recommended protective measures. No eating, drinking, or smoking during use.
Storage: Store in original tightly closed container, away from incompatible substances such as strong acids and oxidizers. Keep in a cool, dry well-ventilated area, protected from sunlight and moisture. Prevent unauthorized access.
Occupational Exposure Limits: No recognized exposure limits available for Niclosamide in most countries
Engineering Controls: Use local exhaust ventilation to control airborne concentrations
Personal Protective Equipment (PPE): Protective gloves: chemical-resistant (e.g., nitrile). Eye protection: goggles or face shield. Clothing: protective coveralls. Respiratory protection: NIOSH-approved mask or respirator if dusts or aerosols might be present.
Appearance: Off-white to yellowish crystalline powder
Odor: Slight, phenolic
Melting Point: Approximately 225°C
Boiling Point: Decomposes before boiling
Solubility: Poorly soluble in water; soluble in organic solvents like acetone, ethanol, and methanol
pH: 5.5–7.5 (1% aqueous solution)
Vapor Pressure: Negligible at ambient conditions
Density: ~1.5 g/cm3
Chemical Stability: Niclosamide remains stable under recommended storage conditions.
Conditions to Avoid: Exposure to strong acids and oxidizing agents accelerates decomposition. Moisture and direct sunlight degrade active components faster.
Hazardous Decomposition Products: Under fire or high heat, expect toxic releases including CO, CO2, NOx, HCl.
Polymerization: Not known to polymerize.
Acute Oral Toxicity (LD50 rat): 500–1000 mg/kg
Acute Dermal Toxicity (LD50 rabbit): >2000 mg/kg
Acute Inhalation Toxicity: Data limited; considered low volatility
Skin and Eye Irritation: Evidence of moderate irritation in animal studies
Carcinogenicity: No evidence from long-term animal studies
Other Effects: High exposures can affect the liver and gastrointestinal system. Symptoms include nausea, vomiting, and possibly rash.
Toxicity to Fish: LC50 (96 hr, rainbow trout): ~0.21 mg/L
Toxicity to Aquatic Invertebrates: EC50 (48 hr, Daphnia magna): ~0.28 mg/L
Bioaccumulation: Potential for accumulation in aquatic organisms
Persistence and Degradability: Slow degradation, persistent in aquatic environments
Mobility: Poor mobility in soil; binds to soil particles and sediment
Product Disposal: Incinerate or dispose according to national or local regulations for hazardous waste. Avoid direct release to environment.
Contaminated Packaging: Empty containers still hold product residues. Rinse carefully and dispose of containers at licensed facility.
Additional Information: Do not reuse empty containers. Wash hands and any contaminated skin thoroughly after handling.
UN Number: 3077
Proper Shipping Name: Environmentally Hazardous Substance, Solid, N.O.S. (Niclosamide)
Transport Hazard Class: 9 (Miscellaneous dangerous substances)
Packing Group: III
Environmental Hazards: Marine pollutant
Special Precautions: Ensure packaging prevents leaks and prevents exposure to moisture and sunlight during transit. Follow carrier and local authority requirements for hazardous materials.
US EPA: Registered pesticide; subject to FIFRA regulations
EU Classification: Regulated as hazardous; included in Annex I pesticide list
Inventory Status: Listed in TSCA (USA), EINECS (EU), and other global chemical inventories
Relevant Legislation: Subject to national rules on pesticide use, safe handling, worker protection standards and adverse event reporting
Labeling Requirements: Minimum content of active ingredient, hazard pictograms, signal words, and emergency contact details must be present on packaging
