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Product Name: Naloxone Hydrochloride
Chemical Formula: C19H21NO4·HCl
Synonyms: Narcan; N-allylnoroxymorphone hydrochloride
CAS Number: 357-08-4
Intended Use: Opioid overdose reversal
Supplier: Contact pharmaceutical manufacturer for details
Emergency Contact: Refer to poison control or local emergency medical services
Classification: Not classified as hazardous under GHS for normal handling
Health Risks: May cause respiratory or central nervous system effects
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Label Elements: None required for natural exposure; consult local regulation
Signal Words: Not applicable
Precautionary Statements: Avoid inhalation and contact with skin or eyes; use personal protective equipment as needed
Chronic Effects: Prolonged or repeated exposure may cause discomfort
Symptoms of Overexposure: Nausea, drowsiness, respiratory effects
Substance: Naloxone Hydrochloride
Active Ingredient: Naloxone Hydrochloride (≥98% purity)
Other Ingredients: May contain stabilizers, buffers (e.g., sodium chloride, hydrochloric acid for pH adjustment)
Impurities: Typically less than 1%, see batch-specific certificate
Formulation: Injection solution, nasal spray, or bulk powder
Inhalation: Move to fresh air; seek medical attention if symptoms persist
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing
Eye Contact: Rinse immediately under running water for minimum 15 minutes; seek ophthalmologist review if irritation develops
Ingestion: Seek immediate medical help; do not induce vomiting unless directed by medical personnel
Protection for First Aiders: Personal protective clothing, gloves; avoid direct contact with product
Symptoms: Shortness of breath, headache, dizziness
Notes to Physician: Symptomatic treatment only; observe for respiratory or CNS symptoms
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Media: Avoid high-pressure water streams
Fire Hazards: Product does not ignite easily; may emit toxic fumes (nitrogen oxides, carbon monoxide) under fire
Protective Equipment: Self-contained breathing apparatus, full protective gear
Firefighting Instructions: Evacuate area, cool containers with water spray
Combustion Products: Hazardous fumes of hydrogen chloride and nitrogen compounds
Special Considerations: Prevent runoff from contaminating waterways
Personal Precautions: Use gloves, protective eyewear, dust mask; avoid breathing dust or vapor
Environmental Precautions: Prevent entry into drains, water systems
Spill Cleanup Methods: Sweep or scoop spilled powder carefully; avoid dust generation; place in suitable container for disposal
Decontamination: Wash spill area with water and suitable cleaning agents
Waste Disposal: Dispose of in accordance with local regulations
Notification: Inform authorities if product enters water, drains, or soil in significant quantities
Handling: Use only in well-ventilated area; avoid contact with skin, eyes, and clothing; prevent dust and aerosol generation; wash hands after handling
Storage: Store at controlled room temperature (approximately 15–25°C); keep away from incompatible materials such as strong oxidizers or acids
Container Recommendations: Store in tightly closed, original containers; properly labeled
Incompatibilities: Avoid strong oxidizing agents, strong acids
Special Storage Precautions: Protect from light and moisture; do not freeze liquid formulations
Shelf Life: Refer to product labeling or certificate of analysis
Engineering Controls: Local exhaust ventilation, safety cabinets, fume hood
Personal Protective Equipment: Laboratory coat, gloves (nitrile or latex), safety glasses with side shields
Respiratory Protection: Dust mask or respirator if aerosol generation possible
Hand Protection: Chemically resistant gloves; change frequently
Eye/Face Protection: Safety goggles or face shield
Workplace Hygiene: Avoid eating, drinking, or smoking in work area; wash thoroughly after handling
Environmental Controls: Use containment procedures to reduce environmental exposure
Exposure Limits: Not established specifically for naloxone hydrochloride; minimize occupational exposure as much as possible
Appearance: White to off-white powder (bulk); clear, colorless solution (injection)
Odor: Odorless
Boiling Point: Not applicable (decomposes)
Melting Point: Around 200°C (decomposes)
Solubility: Freely soluble in water; sparingly soluble in ethanol
pH (solution): Typically 3.0–5.0 (in aqueous solution)
Vapor Pressure: Negligible
Partition Coefficient (log P): -0.96 (indicative of hydrophilic nature)
Relative Density: About 1.43 g/cm³ (as hydrochloride salt)
Oxidizing Properties: Not an oxidizer
Evaporation Rate: Not applicable
Chemical Stability: Stable under normal operating and storage conditions
Decomposition: Decomposes at high temperatures producing toxic fumes
Reactivity: Reacts with strong oxidizing agents and acids
Polymerization: Will not occur
Incompatible Materials: Strong acids, strong oxidizers
Hazardous Decomposition Products: Produces nitrogen oxides, hydrogen chloride, carbon monoxide, carbon dioxide when heated or burned
Conditions to Avoid: Keep away from extreme temperatures, moisture, and direct sunlight
Acute Toxicity: Low toxicity by skin contact, ingestion, or inhalation under typical handling conditions
LD50 (oral, rat): Approximately 60 mg/kg
LD50 (intravenous, rat): 47 mg/kg
Skin Sensitization: Not classified as a skin sensitizer
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Mutagenicity: Negative in standard in vitro and in vivo assays
Reproductive Toxicity: No evidence in animal studies
Chronic Effects: Limited data; no known cumulative health effects in intended usage
Common Symptoms: Respiratory or central nervous system effects if exposed to high doses
Ecotoxicity: Information limited; not expected to pose significant risk at usual environmental concentrations; large spills can impact aquatic organisms
Persistence and Degradability: Expected to degrade in the environment through normal biological processes
Bioaccumulation Potential: Low due to hydrophilic properties; unlikely to accumulate in aquatic organisms
Mobility in Soil: Anticipated to be mobile in water and soil due to solubility
Aquatic Toxicity: Acute LC50 (fish) not established
Other Adverse Effects: Avoid release to the environment; proper waste handling and containment support ecological safety
Waste Handling: Collect and transfer to hazardous waste facility according to local, regional, and national requirements
Disposal Methods: Incineration under controlled conditions preferred; chemical burial permitted within guidelines
Container Handling: Empty and decontaminate containers prior to recycling or disposal
Precautions: Prevent environmental contamination by ensuring proper containment
Regulatory Notes: Product and any contaminated packaging classified as pharmaceutical waste
UN Number: Not classified as dangerous goods for transport
Proper Shipping Name: Naloxone Hydrochloride (non-hazardous)
Transport Hazard Class: Not regulated
Packing Group: Not assigned
Labels: No specific hazard labels required under UN/ADR/IATA/IMDG regulations
Special Precautions: Prevent damage to packaging; store at recommended temperature during shipment; avoid exposure to light and moisture during transit
Reportable Quantity (RQ): No established RQ
GHS Classification: Not classified as hazardous by GHS standards
OSHA Status: Not a hazardous chemical per OSHA Hazard Communication Standard
SARA Title III: Not listed
TSCA: Product not listed
RCRA Status: Pharmaceutical waste; dispose as hazardous waste per federal/state/local rules
EU Regulations: Not considered a dangerous substance per Regulation (EC) No 1272/2008
Inventory Status: Controlled substance in some jurisdictions; schedule and handling may be regulated
Other Regulations: Use subject to prescription laws, environmental, and occupational health protections
Labeling Requirements: Must display correct product name, concentration, manufacturer information, batch/lot number, and expiration date
