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Product Name: Minoxidil
Chemical Name: 6-(1-piperidinyl)-2,4-pyrimidinediamine 3-oxide
Synonyms: 2,4-Diamino-6-piperidinopyrimidine-3-oxide
CAS Number: 38304-91-5
Recommended Use: Topical treatment for hair loss
Manufacturer Details: Information provided on manufacturer label
Emergency Contact: Refer to local regulatory body or poison control center
Classification: Not classified as hazardous under GHS standards for dermal application, but hazardous if ingested or inhaled in large quantities
Risk Phrases: May cause skin and eye irritation, toxic by ingestion, may affect cardiovascular function if misused
Pictograms: Exclamation mark for irritant, health hazard symbol
Signal Word: Warning
Hazard Statements: H302 – Harmful if swallowed. H315 – Causes skin irritation. H319 – Causes serious eye irritation
Precautionary Statements: Keep away from children. Do not ingest or inhale dust. Avoid skin and eye contact unless indicated
Active Ingredient: Minoxidil – 2% or 5% concentration by volume in topical preparations
Inactive Ingredients: Ethanol (solvent), propylene glycol (solvent and penetration enhancer), purified water
Impurities: None typically identified when produced to pharmacopeial standards
Ingredient Purity: Pharmaceutical grade, meets applicable USP/BP specifications
Inhalation: Move to fresh air immediately. Seek medical advice if symptoms persist
Skin Contact: Wash thoroughly with soap and water. Remove contaminated clothing and launder before reuse
Eye Contact: Rinse immediately with plenty of water for at least fifteen minutes. Get prompt medical attention if irritation continues
Ingestion: Do not induce vomiting. Rinse mouth with water. Get medical help immediately
Most Important Symptoms: Redness, dryness, irritation to skin or eyes, systemic toxicity if large amounts swallowed
Medical Attention and Special Treatment: Symptomatic treatment and supportive care
Suitable Extinguishing Media: Use dry powder, foam, carbon dioxide, or water spray for small fires. Avoid high-pressure water streams
Unsuitable Extinguishing Media: Strong water jets may spread spills
Hazards from Combustion Products: May emit toxic fumes such as nitrogen oxides and carbon monoxide
Special Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Additional Fire Response Guidance: Cool containers with water spray to prevent bursting from heat exposure
Personal Precautions: Wear gloves, eye protection, and lab coat or apron to avoid direct skin and eye contact
Environmental Precautions: Prevent entry into drains or waterways to avoid environmental contamination
Methods for Containment: Absorb with inert materials like vermiculite or sand. Contain and collect as per local disposal regulations
Clean-up Procedures: Wipe small spills with suitable absorbent material, dispose properly. Ventilate area
Emergency Procedures: Isolate area if large quantities are released
Handling: Avoid contact with skin, eyes, and clothing. Do not ingest, inhale, or allow prolonged exposure. Wash hands after use
Storage Conditions: Store at room temperature, away from light, heat, and direct sunlight. Keep tightly closed in original container
Incompatibilities: Avoid strong oxidizing agents and acids
Special Requirements: Store out of reach of children, keep away from food and beverages
Storage Class: As per local regulations for pharmaceuticals
Exposure Limits: No occupational exposure limit established for minoxidil
Engineering Controls: Use with adequate ventilation or in a fume hood if preparing formulations
Personal Protective Equipment (PPE): Lab gloves, eye protection (goggles), protective lab coat
Respiratory Protection: Not typically required for end-users, but dust mask or respirator for industrial handling
Hygiene Measures: Do not eat, drink, or smoke while handling. Wash exposed skin thoroughly before breaks and after handling
Appearance: White to off-white crystalline powder; available as clear to slightly yellow solution in topical products
Odor: Odorless or faint, characteristic odor due to solvents
Odor Threshold: Not available
pH: 4.0–5.0 (solution)
Melting Point/Freezing Point: 248–268°C (decomposition)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not determined
Evaporation Rate: Not determined
Flammability: Product solvent may be flammable (ethanol present in topical solution)
Vapor Pressure: Not determined
Solubility in Water: Soluble
Partition Coefficient (n-octanol/water): Not available
Vapor Density: Not determined
Relative Density: Not determined
Auto-Ignition Temperature: Not established
Decomposition Temperature: Above 240°C
Viscosity: Similar to water for topical solutions
Chemical Stability: Stable at normal ambient conditions in sealed container
Reactivity: Not reactive under standard use or storage conditions
Conditions to Avoid: High heat, open flame, strong light, and incompatible materials
Incompatible Materials: Strong oxidizers, acids, alkalies
Hazardous Decomposition Products: Burning may produce carbon monoxide, carbon dioxide, and nitrogen oxides
Polymerization: Not expected under normal handling and storage
Acute Toxicity: Oral LD50 in rats approximately 1321 mg/kg. Not for oral ingestion; can cause severe effects if swallowed
Chronic Toxicity: Extended or repeated dermal exposure may cause skin irritation or allergic reactions in rare cases
Likely Routes of Exposure: Dermal, ocular, accidental ingestion
Symptoms of Exposure: Headache, tachycardia, water retention, skin and eye irritation, rarely systemic poisoning
Carcinogenicity: No evidence for carcinogenic effects in humans or animals
Mutagenicity and Teratogenicity: No evidence found in standard studies
Target Organs: Heart and kidneys with excessive systemic exposure
Sensitization: Very rare, but possible with repeated contact
Aquatic Toxicity: Minimally toxic to aquatic organisms at environmental levels from consumer use
Persistence and Degradability: Expected to be biodegradable with environmental exposure
Bioaccumulation Potential: Low potential based on water solubility and rapid metabolism
Mobility in Soil: Moderate mobility; soluble in water
Other Adverse Effects: Large spills or improper disposal can harm aquatic environments or water sources
Waste Disposal Methods: Collect and dispose of according to local, regional, and national regulations for pharmaceutical waste
Containers: Safely empty containers and dispose as hazardous or pharmaceutical waste. Do not reuse packaging
Special Precautions: Prevent product or waste from contaminating water supplies or drains
Handling of Waste: Trained personnel using suitable PPE and disposal methods
UN Number: Not classified as dangerous good for transport
UN Proper Shipping Name: Minoxidil solution (not regulated)
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Marine Pollutant: Not applicable
Special Precautions: Ship in tightly closed original container, avoid temperature extremes
Transport Labels: Not required
Regulatory Status: Approved for topical use by FDA and equivalent standards in many countries, regulated as a pharmaceutical product
Inventory Listings: Listed in international chemical inventories where applicable
Safety, Health and Environmental Regulations: Complies with standards set for over-the-counter topical drugs. Subject to workplace safety laws regarding chemical handling
Labelling Requirements: Compliant with national drug labelling and consumer product standards. Must feature hazard warnings and use instructions
Other Regulations: Additional restrictions or requirements may apply in specific jurisdictions; consult local health authority
