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Product Name: Lysergic Acid Methyl Ester
Chemical Formula: C17H17N3O2
CAS Number: 297-90-5
Other Names: Ergoline-8-carboxylic acid, 9,10-didehydro-6-methyl-, methyl ester
Manufacturer/Supplier: Chemical research labs and certified chemical supply vendors
Use: Research and chemical synthesis; not intended for human or veterinary drug use
Risk Classification: Harmful if swallowed, toxic if inhaled, potential skin irritant, eye irritant
Signal Word: Danger
Hazard Statements: May affect nervous system, possible teratogen, contact may cause allergies in sensitive individuals, suspected of causing genetic defects, repeated exposure may damage organs
Precautionary Statements: Do not breathe dust, vapors, or spray; avoid skin/eye contact; wash thoroughly after handling; use only in well-ventilated areas with certified fume hoods
Hazard Routes: Absorbed by ingestion, inhalation, and dermal contact; special concern with fine particulate and powder forms which disperse in air easily
Chemical Name: Lysergic Acid Methyl Ester
Synonyms: N/A for laboratory reference
Concentration: Pure compound (≥98%)
Impurities: Trace ergoline alkaloids from synthesis (≤2%)
Additives: None, research-grade substance supplied pure
Inhalation: Move victim to fresh air immediately, seek medical assistance if symptoms (headache, dizziness, confusion, respiratory distress) develop
Skin Contact: Remove contaminated clothing, wash affected area with copious amounts of soap and water, seek medical attention for persistent irritation or allergic reaction
Eye Contact: Flush eyes gently with clean water for at least 15 minutes, lifting upper and lower lids, obtain immediate medical care
Ingestion: Do not induce vomiting; rinse mouth with water if conscious, call poison control center and request urgent professional evaluation
Advice for Medical Personnel: Symptomatic and supportive treatment, monitor neurological and cardiac status, evaluate for serotonin syndrome in case of significant ingestion
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, sand for small fires; avoid high-pressure streams
Fire/Explosion Hazards: May release toxic fumes under combustion (carbon monoxide, nitrogen oxides, indoles)
Protective Equipment: Wear self-contained breathing apparatus, full firefighting gear, avoid inhalation of combustion products
Special Procedures: Evacuate non-essential personnel, cool containers exposed to heat with water spray from safe distance, prevent run-off entering water systems
Decomposition Products: Emission of irritant organic vapor possible
Personal Precautions: Evacuate immediate area, restrict entry, ensure proper ventilation, wear gloves, goggles, and respiratory protection rated for organic vapors/particulates
Environmental Precautions: Prevent direct release to drain, surface water, groundwater; secure area to avoid contamination; use absorbent inert material (sand, diatomaceous earth) for clean-up
Spill Clean-up: Collect solid residues using non-sparking tools, place in labeled waste container for controlled disposal; wash area thoroughly after removal
Decontamination: Use laboratory-grade detergent, avoid use of strong oxidizers for initial cleanup
Reporting: Notify supervisors and local regulatory agencies if large spills risk environmental contamination
Handling: Handle inside fume hood, wear gloves (nitrile, not latex), chemical splash goggles, lab coat; avoid ingestion routes; do not pipet by mouth; wash hands and exposed skin thoroughly after use
Storage: Store in tightly closed, clearly labeled containers; keep away from light, heat sources, and moisture; recommended storage at 2–8°C in ventilated, access-controlled chemical storage unit; segregate from oxidizers and acids
Incompatibilities: Strong acids, strong bases, oxidizing agents
Technical Controls: Use certified chemical safety cabinets for long-term storage; minimize splashing and airborne particles when transferring
Exposure Limits: No official occupational exposure limits set; treat as potentially hazardous substance
Engineering Controls: Chemical fume hood, glovebox, local exhaust; negative-pressure workspaces reduce airborne exposure
Eye/Face Protection: Chemical splash goggles covering sides
Skin Protection: Nitrile gloves, full-length laboratory coat, closed-toe shoes
Respiratory Protection: Use NIOSH-rated respirator for organic vapors/particulates under spill or dust conditions
Other Protective Measures: Wash hands before breaks and after handling, decontaminate work surfaces after procedures
Physical State: Crystalline powder
Color: White, may exhibit pale color variation
Odor: Odorless or faint characteristic chemical scent
Molecular Weight: 295.34 g/mol
Melting Point: 188–192°C (lit.)
Boiling Point: Not defined, decomposes at elevated temperature
Solubility: Soluble in ethanol, methanol, chloroform, sparingly soluble in water
pH: Not applicable
Density: Not reported
Flash Point: Not determined
Evaporation Rate: Not relevant for solid
Partition Coefficient: Not established
Vapor Pressure: Negligible at room temperature
Chemical Stability: Stable under recommended storage and handling; decomposes with prolonged exposure to heat, light, acids, strong oxidizers
Reactivity: May react vigorously with oxidizing materials, acids
Hazardous Decomposition Products: Carbon monoxide, nitrogen oxides, toxic indolic organic fragments
Polymerization: Not known to occur under normal handling conditions
Conditions to Avoid: Exposure to direct sunlight, heat sources, strong acids, strong bases
Routes of Exposure: Oral, inhalation, dermal, ocular
Acute Toxicity: Toxic effects likely at low mg/kg range in rodents by ingestion; data in humans not standardized due to ethical research limitations
Chronic Toxicity: Possible persistent CNS effects, behavioral and psychological impact, reports suggest roles in mutagenicity/teratogenicity in related ergoline compounds
Symptoms of Overexposure: Severe agitation, hallucinations, CNS excitation, contact dermatitis (rare), mucous membrane irritation
Sensitization: Known ergoline alkaloids show sensitizing potential
Carcinogenesis: No IARC classification; insufficient data for human risk
Reproductive/Developmental Effects: Structural analogs exhibit some risk for embryo toxicity and fetal malformations; pregnant personnel advised not to handle
Ecotoxicity: Risk to aquatic life not fully studied; structurally related substances show moderate persistence, potential toxicity to fish and invertebrates
Persistence and Degradability: Organic structure resists rapid breakdown in both soil and aquatic systems
Bioaccumulation Potential: Limited information, but predicted moderate bioaccumulation due to low water solubility and high organic affinity
Mobility in Soil: Adsorbs to soils and sediments, low migration expected
Other Effects: No data for ozone depletion or global warming impact
Waste Treatment Methods: Dispose of as hazardous organic chemical waste; do not discharge to drains or open environment
Container Disposal: Rinse empty containers with non-flammable solvent, collect rinsate for disposal; deface label and deliver to licensed waste handler
Unused Material Disposal: Incineration at regulated high-temperature chemical waste incinerator
Precautions for Disposal: Always consult local, regional, national regulations for controlled substances; retain records of disposal
UN Number: Not officially assigned; laboratory chemical transport only
Proper Shipping Name: Chemical substance, non-specific, not for public use
Hazard Class: Not classified for transport under GHS, but treat as toxic
Packing Group: III (low danger), based on chemical hazard for similar ergoline compounds
Special Precautions: Keep sealed, ship under cool, ventilated conditions, provide all required documentation for chemical research materials
Regulatory Restrictions: Confirm local legal status before shipment; international protocols for controlled substances apply
Chemical Inventory Status: Not registered under TSCA, REACH, or NDSL; considered controlled substance or precursor in many jurisdictions
Lab Use Only: Research use only, not for food, drug, or household use
International Agreements: Transport and possession may fall under UN convention and national regulatory restrictions for hallucinogenic substances
Warning Labels: Must include standardized warning for laboratory handling, hazard symbols for acute toxicity and health hazard
Worker Rights: Facilities must enforce chemical hygiene plans, training for exposure, and access to emergency resources
