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Product Name: Levonorgestrel
Chemical Name: (17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one
Synonyms: Norlevo, Plan B, Postinor, Levonelle, Escapelle
CAS Number: 797-63-7
Recommended Use: Pharmaceutical applications, emergency contraception, hormone therapy
Manufacturer Information: Various pharmaceutical manufacturers globally
Emergency Phone Number: Available from local poison control centers or supplier SDS contacts
Classification: Reproductive toxicity (Category 1B), Specific Target Organ Toxicity (Category 2), Skin and eye irritant
Signal Word: Danger
Hazard Statements: May damage fertility or the unborn child. Causes skin irritation. Causes serious eye irritation. Harmful if swallowed or inhaled.
Pictogram: Health hazard, exclamation mark
Precautionary Statements: Avoid breathing dust or vapors. Wear protective gloves, clothing, and eye protection. Wash hands thoroughly after handling. Obtain special instructions before use. If medical advice is needed, have product container or label at hand.
Chemical Name: Levonorgestrel
Concentration: Typically 99% for active ingredient
CAS Number: 797-63-7
Molecular Formula: C21H28O2
Impurities: Trace pharmaceutical excipients (usually lactose, starch in finished products)
Inhalation: Move individual to fresh air and keep at rest. Seek immediate medical attention if respiratory symptoms occur.
Skin Contact: Remove contaminated clothing. Rinse affected area thoroughly with soap and water for at least 15 minutes. Contact healthcare provider if irritation persists.
Eye Contact: Rinse thoroughly with water for several minutes holding eyelids open. Remove contact lenses safely if present and easy to do. Seek medical assessment.
Ingestion: Rinse mouth and do not induce vomiting. Medical observation recommended. Immediate transport to clinic if symptoms such as nausea, vomiting, or abdominal pain develop.
Most Important Symptoms: Nausea, contact dermatitis, headache, dizziness, reproductive system symptoms in high exposure
Extinguishing Media: Use water spray, dry chemical powder, foam, or carbon dioxide.
Specific Hazards: Combustion may produce toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
Advice: Evacuate personnel to a safe area. Prevent run-off from entering drains or water courses.
Personal Precautions: Use protective equipment to prevent skin and eye contact. Avoid dust formation and inhalation.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Avoid contamination of water bodies and drains.
Methods for Containment: Collect material with inert absorbent and place in suitably labeled containers for disposal.
Clean-up Procedures: Wipe surfaces with damp cloth after collection of solid. Ventilate affected area. Dispose of cleaning materials according to local regulations.
Handling: Avoid formation of dust and inhalation of particulate. Avoid contact with skin and eyes. Use local exhaust ventilation if available.
Storage: Keep stored in tightly closed, original container. Store in a cool, dry, well-ventilated place away from incompatible materials such as oxidizing agents. Protect from excessive heat and direct sunlight.
Incompatibilities: Avoid mixing with acids, bases, strong oxidizers.
Exposure Limits: No official occupational exposure limits available; minimize exposure as low as reasonably achievable.
Engineering Controls: Use well-ventilated areas, local exhaust if handling bulk material, safety shower and eyewash station recommended.
Personal Protective Equipment: Safety glasses or chemical goggles, impermeable gloves (such as nitrile), lab coat or gown, dust mask or respirator if dust levels are high.
Hygiene Measures: Wash hands thoroughly after handling. Change contaminated clothing immediately.
Appearance: White to off-white crystalline powder
Molecular Weight: 312.45 g/mol
Odor: Odorless
Solubility: Slightly soluble in water, soluble in ethanol and methanol
Melting Point: 232–239°C
Boiling Point: Data not available; decomposes on heating
Vapor Pressure: Negligible at room temperature
Density: About 1.2 g/cm³
pH: Not applicable (non-aqueous solid)
Partition Coefficient (log Pow): 3.65
Chemical Stability: Stable under normal conditions of handling and storage.
Reactivity: No hazardous reactivity expected under prescribed conditions.
Hazardous Decomposition Products: Decomposition in fire may produce carbon dioxide, carbon monoxide, nitrogen oxides.
Incompatible Materials: Strong oxidizing agents, acids, bases.
Polymerization: Will not occur.
Acute Toxicity: Oral LD50 in rats > 6000 mg/kg
Chronic Toxicity: Long-term repeated exposure can affect reproductive system and hormone balance
Possible Effects: Nausea, headache, breast tenderness, mood change in therapeutic dose; higher exposures linked to menstrual disturbances, potential teratogenesis in lab animals.
Irritation/Corrosivity: May cause skin and eye irritation.
Sensitization: Not classified as a sensitizer.
Carcinogenicity: Not classified as cancer-causing in humans
Mutagenicity: No mutagenic effects found in standard tests
Reproductive Toxicity: May cause developmental effects; not for use during pregnancy except as indicated
Ecotoxicity: May be harmful to aquatic organisms at low concentrations. Disruption of endocrine system in fish observed in laboratory studies.
Persistence and Degradability: Low to moderate persistence in environment; slow biodegradation
Bioaccumulation: Potential for bioaccumulation in aquatic species due to lipophilicity
Mobility in Soil: Limited mobility because of low water solubility
Other Adverse Effects: Small amounts may enter natural water bodies through pharmaceutical use, potentially impacting wildlife.
Waste Disposal Methods: Dispose of in accordance with national and local regulations for pharmaceutical waste. Do not flush into drains or release to environment.
Contaminated Packaging: Triple rinse containers if regulations permit, or dispose as pharmaceutical waste.
Special Precautions: Consult an approved waste disposal contractor for large quantities or spill residues.
Disposal Code: Hazardous waste code may apply in certain jurisdictions.
UN Number: Not regulated for ground, sea, or air transport
Proper Shipping Name: Not regulated (Levonorgestrel-containing articles may be subject to special regulations in some areas)
Transport Hazard Class: Not classified as a hazardous material
Packing Group: Not applicable
Environmental Hazards: Avoid release to waterways
Special Precautions for User: Use original container and labeling; avoid exposure and breakage in transit.
Labeling Requirements: Label containers with substance name, hazards, and handling instructions
SARA Title III (U.S.): Not listed
RCRA (U.S.): Not listed as a hazardous waste
TSCA (U.S.): Exempt as a pharmaceutical ingredient
REACH (EU): Regulated as a substance of very high concern (SVHC) if handled in bulk
OSHA Classification: Hazardous chemical, requires workplace controls
WHMIS (Canada): Not a controlled product, but workplace precautions apply
Other: Product subject to local pharmaceutical regulations and prescription controls.
