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Product Name: Ledipasvir Acetone Complex
Synonyms: No known synonyms
Chemical Family: Pharmaceutical Intermediate
Recommended Use: Research and chemical analysis
Manufacturer Contact: Hazard Safety Division, Safety Support Center
Emergency Telephone: Refer to local hazardous material emergency line
CAS Number: Sourced upon product specification
Address: Facility-specific
Email Contact: Safety reporting official or chemical hygiene officer
GHS Classification: Flammable liquid, Category 3; Acute toxicity (oral), Category 4; Eye irritation, Category 2A
Signal Word: Warning
Hazard Pictograms: Flame, Exclamation mark
Hazard Statements: May cause irritation to eyes and respiratory tract. Flammable liquid and vapor. Harmful if swallowed.
Precautionary Statements: Keep away from heat/sparks/open flames. Wear protective gloves and eye protection. Do not eat or drink near the compound. Wash thoroughly after handling.
Other Hazards: Vapors spread long distances and may ignite remotely. Can cause dizziness or drowsiness.
Chemical Name: Ledipasvir Acetone Complex
Common Name: NA
Constituent Components: Ledipasvir (C49H54F2N8O6), Acetone (C3H6O)
Concentration: Ledipasvir ∼ 90-98%, Acetone ∼ 2-10%
Impurities: Manufacturing-related trace residues
CAS Number (Acetone): 67-64-1
Molecular Formula: Variable based on hydrate/complex.
EC Number (Acetone): 200-662-2
General Advice: Seek immediate medical attention for symptoms after exposure.
Eye Contact: Rinse cautiously with water for at least 15 minutes. Remove contact lenses.
Skin Contact: Wash with plenty of soap and water. Remove contaminated clothing.
Ingestion: Do not induce vomiting. Rinse mouth with water. Get medical help.
Inhalation: Move victim to fresh air. Provide oxygen if breathing is difficult. Seek medical care.
Note to Physicians: Symptomatic treatment recommended. Monitor respiratory and cardiovascular systems.
Suitable Extinguishing Media: Dry chemical, CO2, foam. Use water spray for cooling exposed containers.
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen fluoride, toxic fumes
Specific Fire Hazards: Vapors may travel and flash back. Containers may explode on heating.
Protective Equipment: Self-contained breathing apparatus and full protective gear
Advice for Firefighters: Always remain upwind, avoid inhaling combustion products. Remove undamaged containers if safe.
Personal Precautions: Evacuate nonessential personnel. Wear chemical-resistant gloves, goggles, and respirators.
Environmental Precautions: Prevent run-off to drains, sewers, or waterways. Notify environmental authorities.
Methods for Containment: Contain spill with sand, non-combustible material.
Methods for Cleaning Up: Absorb with chemically inert material, collect in closed compatible containers for disposal.
Decontamination: Wash area thoroughly with water and detergent after removal.
Safe Handling Advice: Minimize dust and vapor formation. Use only with ventilation or in fume hood. Use antistatic grounding if transferring liquid parts.
Storage Conditions: Store away from sunlight and ignition sources in a cool, dry, well-ventilated location.
Incompatible Materials: Strong oxidizers, acids, and bases
Container Requirements: Use tightly sealed certified chemical containers. Clearly label all containers.
Special Considerations: Track inventory and minimize on-site stocks.
Occupational Exposure Limits: Acetone TWA (OSHA): 1000 ppm (2400 mg/m³)
Engineering Controls: Chemical fume hood, local exhaust ventilation, explosion-proof equipment
Personal Protection: Nitrile gloves, safety goggles or full-face shield, lab coat, respirators for high vapor concentrations
Hygiene Measures: No food or drink in area, wash hands after use, remove contaminated clothing.
Appearance: White to off-white powder, faint acetone odor
Physical State: Solid complex
Odor Threshold: Detectable by faint ketone odor
pH: Not applicable
Melting Point/Range: Ledipasvir: 235-245°C; Acetone: -94°C (component only)
Boiling Point/Range: Acetone: 56°C (component only)
Flash Point: Acetone: -18°C (component only)
Evaporation Rate: Not established for complex
Vapor Pressure: Low as solid; relevant for acetone (component) 24 kPa at 20°C
Solubility: Sparingly soluble in water; soluble in organic solvents
Partition Coefficient: Not available
Viscosity: Not applicable
Decomposition Temperature: Not established; decomposes with toxic gases
Chemical Stability: Stable under recommended storage and handling conditions
Possible Hazards: Thermal decomposition releases hazardous gases
Reactivity: Reactive with strong oxidizers and acids
Polymerization: No data on dangerous polymerization under normal conditions
Conditions to Avoid: Excess heat, flames, direct sunlight, static discharge
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, HF, volatile solvents
Incompatible Materials: Acid chlorides, acid anhydrides, chloroformates
Likely Routes of Exposure: Inhalation, eye and skin contact, ingestion
Acute Toxicity: Harmful if swallowed. Can cause skin and eye irritation. Acetone LC50 (inhalation-rat): 50100 mg/m³ 8h, LD50 (oral-rat): 5800 mg/kg
Chronic Toxicity: Repeated exposure to acetone may cause dryness, headaches, dizziness
Symptoms: Eye burning, respiratory tract irritation, confusion, nausea
Carcinogenicity: No regulatory listing for carcinogenicity (IARC, NTP, OSHA)
Mutagenicity, Teratogenicity, Reproductive Toxicity: No conclusive human data for the complex
Sensitization: Not expected with standard lab procedures
Other Data: Risk increases with lack of ventilation and lack of PPE
Aquatic Toxicity: Acetone is moderately toxic to aquatic life (LC50: 5–100 mg/L for fish)
Soil Impact: Leaching may contaminate groundwater
Persistence and Degradability: Acetone readily biodegradable, ledipasvir long-term persistence not established
Bioaccumulation Potential: Low for acetone; not available for ledipasvir
Other Adverse Effects: Spills may disrupt soil microflora
Mobility in Soil: Acetone has high mobility; ledipasvir complex expected low mobility due to low solubility
Waste Treatment Methods: Collect waste in properly labeled chemical-resistant containers
Disposal of Waste: Dispose in accordance with local, regional and federal regulations. Incinerate using chemical waste incinerator with afterburner and scrubber.
Disposal of Contaminated Packaging: Triple rinse prior to recycling or disposal
Precautions: Do not pour into drains or the natural environment
Recycling Options: Not recommended for reuse due to contamination risk
UN Number: UN1090 (Acetone component)
Proper Shipping Name: Acetone, Mixture (as applicable)
Hazard Class: 3 (Flammable Liquid)
Packing Group: II
Marine Pollutant: Acetone: No; Ledipasvir: Data unavailable
Transport Label: Flammable Liquid
Special Precautions: Avoid heat, transport in compliance with national and international dangerous goods regulations.
US Regulations (TSCA): Acetone listed; Ledipasvir not listed
Canadian Regulations: Acetone on DSL/NDSL; Ledipasvir special use only
EU Regulations (REACH): Acetone registered; Ledipasvir: specific registration status relative to medicinal use
OSHA Hazards: Combustible liquid, irritant
WHMIS Classification: B2, D2B for acetone
SARA Title III: Acetone subject to reporting, thresholds apply
Other International Regulations: Comply with all local, regional or national requirements for storage, handling, and disposal
