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Product Name: Ketanserin Tartrate
Chemical Name: (3-[2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl]quinazoline-2,4(1H,3H)-dione tartrate)
Synonyms: Ketanserin Hemitartrate
CAS Number: 74150-27-9
Molecular Formula: C22H22FN3O3·C4H6O6
Molecular Weight: 581.58 g/mol
Intended Use: Laboratory chemical, research and manufacturing
Hazard Class: Acute Toxicity (oral, inhalation), Eye Irritation, Skin Sensitization
GHS Classification: Harmful if swallowed, causes serious eye irritation, may cause allergic skin reaction
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, harmful if swallowed, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves, take off contaminated clothing
Potential Health Effects: Inhalation causes coughing and respiratory discomfort, skin contact reddens and irritates, eye exposure leads to burning and watering, ingestion causes nausea and possible systemic effects
Chemical Component: Ketanserin Tartrate
CAS Number: 74150-27-9
Concentration: ≥98% (by weight)
Impurities: Less than 2% (related substances, residual solvents)
Formula: C26H28FN3O9
Appearance: White to off-white powder
Eye Contact: Hold eyelids apart, rinse eyes thoroughly with water for at least 15 minutes, remove contact lenses if present, seek medical attention
Skin Contact: Remove contaminated clothing, rinse affected skin under running water for at least 15 minutes, wash area with soap and water, seek medical advice if irritation appears
Inhalation: Move person to fresh air, keep comfortable, provide oxygen if breathing becomes difficult, obtain medical help if symptoms persist
Ingestion: Rinse mouth with water, do not induce vomiting, provide small quantities of water to drink if person is conscious, contact poison control or seek immediate medical attention
Notes to Physician: Treat symptomatically and provide supportive care as needed
Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide, water spray
Unsuitable Extinguishing Media: High-pressure water jets
Fire Hazards: Emits toxic fumes of nitrogen oxides, carbon oxides, and fluorine compounds under fire conditions
Protection for Firefighters: Wear self-contained breathing apparatus, full protective clothing, stay upwind, avoid inhaling fumes
Explosion Data: No data for explosion sensitivity to impact or static discharge, treat dust with caution
Personal Precautions: Wear NIOSH/MSHA approved respirator, chemical splash goggles, lab coat, gloves
Environmental Precautions: Prevent entry into sewers, waterways or soil
Containment Procedures: Avoid dust formation, use HEPA-filtered vacuum or damp sweeping, ventilate area
Cleanup Methods: Collect spill in suitable container for disposal, decontaminate area with soap and water
Safe Handling: Handle in a well-ventilated area, avoid inhaling dust or vapor, prevent contact with skin, eyes and clothing, do not eat, drink or smoke near material, wash thoroughly after use
Storage Conditions: Store tightly closed in original container, keep in cool, dry, well-ventilated place, protect from light, keep away from incompatible materials (oxidizers, acids, bases)
Special Requirements: Label containers clearly, avoid generating airborne dust, maintain storage temperature below 25°C
Occupational Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limits
Engineering Controls: Use fume hood or local exhaust to minimize exposure, ensure eyewash stations and safety showers are nearby
Personal Protective Equipment: Chemical-resistant gloves (nitrile or latex), safety glasses with side-shields or goggles, lab coat or coveralls, NIOSH-approved respirator for dust, closed-toe chemical-resistant shoes
Hygiene Measures: Do not eat, drink or smoke while handling, wash hands and face thoroughly after use, change contaminated clothing
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical smell
Odor Threshold: Not determined
pH: 4.0 – 5.5 (1% solution in water)
Melting Point: 251 – 256°C
Boiling Point: Not available
Flash Point: Not determined
Flammability: Not classified as flammable
Vapor Pressure: Negligible at room temperature
Solubility: Soluble in methanol, DMSO; slightly soluble in water
Partition Coefficient: Log Pow: not available
Vapor Density: Not applicable
Evaporation Rate: Not applicable
Decomposition Temperature: Emits toxic fumes at high temperatures
Viscosity: Not applicable
Chemical Stability: Stable under normal ambient and anticipated storage conditions
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Conditions to Avoid: Excess heat, direct sunlight, moisture
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, hydrogen fluoride
Hazardous Polymerization: Will not occur
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg (supplier data)
Chronic Effects: Prolonged or repeated exposure may cause allergic reactions, central nervous system symptoms, and target organ effects
Irritation: Causes eye and skin irritation, respiratory tract discomfort
Sensitization: May cause allergic skin reaction
Mutagenicity: No data available from standard tests
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: Limited animal data, not conclusive for humans
Routes of Exposure: Eye, skin, inhalation, ingestion
Symptoms: Redness, burning, coughing, headache, dizziness, gastrointestinal upset
Ecotoxicity: No specific test data for aquatic toxicity, treat as potentially hazardous
Persistence and Degradability: No significant data, likely only slowly biodegradable
Bioaccumulative Potential: No significant bioaccumulation expected
Mobility in Soil: Expected to be immobile in solid form, avoid environmental release
Other Adverse Effects: No ozone-depletion substances, do not allow to enter drains or waterways
Waste Treatment Methods: Dispose in accordance with local, regional, and national regulations
Product Disposal: Place in marked, sealed containers, send for hazardous material incineration
Contaminated Packaging: Triple rinse, recycle or dispose as chemical waste
Recommended Disposal Code: Waste code based on specific local authority requirements
UN Number: Not regulated for transport
Proper Shipping Name: Not a hazardous material under transport regulations
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Transport Precautions: Keep container tightly closed and upright, protect from moisture and physical damage during transport
Federal Regulations: Listed under TSCA (USA), not subject to SARA Title III Sections 302/304/313
International Regulations: Not classified under EU REACH Annex XVII or XIV; not on Canadian DSL/NDSL as chemical in commerce
Labeling Requirements: GHS-compliant hazard warnings
Chemical Safety Assessment: Not required under current legislative requirements for non-commercial R&D use
State & Local Controls: Check valid local and regional requirements, as variations can apply by country and facility
