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Product Name: Kanamycin Sulfate
Chemical Formula: C18H36N4O11·H2SO4
CAS Number: 70560-17-3
Other Names: Kanamycin monosulfate, Kanamycin A sulfate
Recommended Use: Antibiotic in microbiological testing, pharmaceutical manufacturing
Manufacturer/Supplier: Listed on the commercial package, often available from laboratory suppliers
Contact Information: Available from supplier, often includes emergency phone, address, and responsible person
Classification: Skin Sensitization (Category 1), Acute Toxicity Oral (Category 4), Eye Irritation (Category 2A)
Hazard Symbols: GHS07 (Exclamation Mark), GHS08 (Health Hazard)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause allergic skin reactions, harmful if swallowed
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, do not eat, drink, or smoke when using, wear protective gloves, clothing, and eye protection
Potential Health Effects: Inhalation may result in respiratory irritation, skin may develop sensitization, eyes can experience redness or pain
Environmental Hazards: Toxic to aquatic life through water contamination, risk increases with chronic exposure
Chemical Name: Kanamycin sulfate
Concentration: 95-100%
Chemical Formula: C18H36N4O11·H2SO4
CAS Number: 70560-17-3
Impurities/Additives: None identified in standard-grade product, check Certificate of Analysis for specifics
Inhalation: Move individual to fresh air, keep at rest, seek medical attention for continued symptoms
Skin Contact: Wash area with soap and water, remove contaminated clothing, seek physician care for irritation or sensitization
Eye Contact: Rinse with water for at least 15 minutes, lift eyelids, get immediate medical help if pain, redness, or vision changes occur
Ingestion: Rinse mouth, drink water to dilute, avoid vomiting unless directed by medical personnel, seek medical attention
Most Important Symptoms: Allergic reactions, rash, respiratory irritation, gastrointestinal upset in case of ingestion
Suitable Extinguishing Media: Water spray, foam, carbon dioxide, dry chemical
Unsuitable Extinguishing Media: None reported in standard laboratory settings
Specific Hazards: May emit toxic fumes like nitrogen oxides, sulfur oxides, carbon monoxide in fire scenarios
Protective Equipment: Wear self-contained breathing apparatus, full protective clothing
Special Procedures: Move containers from fire area if safe to do so, use water spray to cool surfaces, avoid run-off into drains
Personal Precautions: Wear gloves, goggles, dust mask, avoid producing dust, ventilate area
Environmental Precautions: Prevent entry into drains, surface or groundwater
Clean-Up Methods: Sweep or scoop up without generating dust, place in labeled waste container, wash contaminated surfaces with water and soap, dispose per local regulations
Emergency Procedures: Evacuate personnel not involved in clean-up, restrict access to area until completion
Handling: Keep container tightly closed, minimize dust generation, use only in ventilated areas, avoid direct contact with skin, eyes, clothing
Safe Storage Conditions: Store in original, sealed packages at 2–8°C (refrigerated), protect from light and moisture
Incompatible Materials: Strong oxidizing agents, strong acids and bases
Hygiene Practices: Wash hands after use, keep food, drink, and personal items away from storage and use areas
Control Parameters: No workplace exposure limits established by OSHA, ACGIH, NIOSH for Kanamycin Sulfate
Engineering Controls: Use lab fume hood or local exhaust ventilation, keep area dust free
Personal Protection: Wear protective gloves (nitrile or latex), safety goggles, standard laboratory coat, use respiratory protection if dust generation is high or ventilation insufficient
Other Protective Equipment: Eye wash and safety shower available at workplace, remove contaminated clothing before entering eating areas
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: 3.5-5.5 (5% solution)
Melting Point/Range: Decomposes before melting
Boiling Point: Not applicable (decomposes)
Flash Point: Not flammable under normal conditions
Evaporation Rate: Not available
Flammability: Not flammable
Vapor Pressure: Negligible
Vapor Density: Not applicable
Solubility: Freely soluble in water, practically insoluble in alcohol or ether
Partition Coefficient (n-octanol/water): Data not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: No data, compound decomposes on heating
Viscosity: Not applicable for solid
Bulk Density: Ranges from 0.5 to 0.7 g/cm3
Chemical Stability: Stable under normal laboratory conditions and recommended storage
Conditions to Avoid: Excessive heat, moisture, exposure to direct sunlight
Materials to Avoid: Strong oxidizing agents, strong acids, bases that may cause degradation
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide and dioxide possible in fire
Hazardous Reactions: No data of violent polymerization or hazardous reactivity under standard conditions
Acute Toxicity: Oral LD50 (rat): 4,650 mg/kg; no significant data for inhalation or dermal routes in humans
Chronic Effects: Prolonged or repeated exposure may cause sensitization or allergic skin reactions, prolonged inhalation of dust could trigger respiratory discomfort
Skin Corrosion/Irritation: May cause mild irritation, especially in sensitive individuals
Eye Damage/Irritation: Redness, tearing, and pain may appear after contact
Sensitization: Potential for allergic reactions in predisposed people
Mutagenicity and Carcinogenicity: No clear evidence for mutagenicity or carcinogenicity in standard tests
Reproductive Toxicity: Animal studies report some reproductive and developmental toxicity at high doses
Specific Target Organ Toxicity: Repeated exposure can affect kidney and hearing in susceptible cases
Other Effects: Kanamycin can affect human kidneys and auditory nerve if absorbed in substantial amount
Ecotoxicity: Harmful to aquatic organisms, risk of long-term adverse effects in aquatic environment
Persistence and Degradability: Antibiotic nature slows down microbial breakdown in soils and water
Bioaccumulation: Not expected to bioaccumulate significantly, partitioning to sediment or sludge possible
Mobility: Water-soluble; likely to move into watercourses from spills
Other Adverse Effects: Release to watercourses can disrupt microbial populations, encourage antibiotic resistance
Waste Treatment Methods: Dispose through licensed hazardous waste contractor, follow local and national regulations
Product Disposal: Do not discharge to sewer systems, waterways, or soil
Contaminated Packaging: Rinse container before recycling or disposal, crush or puncture to prevent reuse
Other Precautions: Avoid mixing with household refuse, consult environmental authority
UN Number: Not regulated as hazardous material for ground, air, or sea transport
Proper Shipping Name: Kanamycin sulfate
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not listed as marine pollutant, avoid release to the environment during shipment
Special Precautions: Package to prevent dust release or container breakage, label with standard identification, consult with freight company for requirements
Labeling Requirements: Follow GHS, OSHA HCS, and local workplace labeling rules
SARA Title III (Sections 311/312): Acute health hazard
California Proposition 65: Not listed
TSCA Status: Listed or exempt
REACH Information: Not registered in Europe, used for research and development purposes only
Other Regulatory Listings: Not designated as carcinogen by IARC, NTP, OSHA
Worker Protection: Provide safety data sheets and training to those handling the product, encourage use of protective gear, report any exposure incidents
