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Material Safety Data Sheet for Gamimycin

Identification

Product Name: Gamimycin
Synonyms: No known synonyms
Recommended Use: Veterinary antibiotic
Manufacturer: Mainline Pharmaceuticals, 439 Edgewater Drive, Houston, TX 77047, USA
Emergency Contact: 1-800-555-8939
Chemical Family: Aminoglycoside antibiotic
Product Code: GMM-501

Hazard Identification

Physical State: Solid powder
Color: White to off-white
GHS Classification: Acute Toxicity (Oral, Category 4); Eye Irritation (Category 2); Respiratory Sensitizer (Category 1); Skin Sensitizer (Category 1)
Signal Word: Danger
Hazard Statements: May cause allergic skin reaction, harmful if swallowed, may cause respiratory irritation, causes serious eye irritation
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Avoid breathing dust, wear protective gloves, use only outdoors or in a well-ventilated area

Composition / Information on Ingredients

Chemical Name: Gamimycin sulfate
CAS Number: 48578-69-4
Concentration: 97–99% by weight
Impurities: Water content below 1%, minimal process residuals
Other Ingredients: None reported as hazardous per OSHA standards

First Aid Measures

Inhalation: Move to fresh air, seek medical advice if symptoms persist such as coughing or wheezing
Skin Contact: Remove contaminated clothing, rinse skin with water for at least 15 minutes, seek attention if irritation develops
Eye Contact: Gently flush eyes with water for several minutes while holding eyelids apart, seek medical care
Ingestion: Rinse mouth with water, do not induce vomiting, give water to drink if alert, get medical help
Most Important Symptoms: Rash, respiratory reaction, eye redness
Immediate Medical Attention: Recommended if allergic reaction is suspected

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, CO₂, foam, or water spray
Unsuitable Methods: Strong water jet (may spread powder)
Specific Hazards: Toxic fumes possible including nitrogen and sulfur oxides
Protective Equipment: Self-contained breathing apparatus, protective clothing
Fire-Fighting Instructions: Move containers away from fire area, prevent run-off into drains, ventilate area afterward

Accidental Release Measures

Personal Precautions: Isolate area, avoid dust formation, use personal protective equipment including gloves and eyewear
Environmental Precautions: Prevent from entering water sources or sewers
Clean-Up Procedures: Sweep or scoop spilled substance using damp method to avoid dust, place in labelled container for waste disposal, ventilate area and wash site after material pickup is complete
Disposal: See 'Disposal Considerations'

Handling and Storage

Handling: Avoid contact with skin and eyes, avoid inhalation of dust, use only with adequate ventilation
Hygiene: Wash hands after handling, remove contaminated clothing before eating or drinking
Storage: Store tightly closed in original container, keep in cool, dry, well-ventilated location, avoid contact with incompatible materials like oxidizers, recommended storage temperature below 30°C
Incompatibilities: Strong acids, bases, and oxidizing agents

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust ventilation or work in fume hood
Threshold Limit Values: Not established for Gamimycin in the US or EU
Personal Protection: Wear chemical-resistant gloves, safety glasses or goggles, laboratory coat
Respiratory Protection: Use approved respirator if dust generation possible
Skin and Eye Protection: Required protective clothing; emergency eye wash and shower stations nearby
Work Practices: Wash hands after handling, keep work area clean

Physical and Chemical Properties

Appearance: White to off-white powder
Odor: Odorless
Odor Threshold: Not specified
pH: 4–6 (1% solution in water)
Melting Point: Decomposes above 200°C
Water Solubility: Freely soluble
Boiling Point: Not applicable (decomposes)
Partition Coefficient (log Kow): Not available
Vapor Pressure: Negligible
Evaporation Rate: Not applicable
Flammability: Not flammable
Explosive Properties: Not explosive

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Decomposition Hazards: May release toxic fumes on thermal decomposition (nitrogen, sulfur oxides)
Reactivity: Not reactive with water under normal use
Incompatible Materials: Strong oxidizers, strong acids and bases
Hazardous Polymerization: Will not occur
Conditions to Avoid: Excess moisture, extreme temperatures, open flames

Toxicological Information

Acute Toxicity: Oral LD50 (rat): 1500 mg/kg (estimated)
Chronic Effects: Repeated exposure may cause allergic reactions, possible nephrotoxicity or ototoxicity
Skin/Eye Contact: Irritation, redness, possible dermatitis
Inhalation: Respiratory sensitization possible, asthma-like symptoms on significant exposure
Carcinogenicity: No data available; no classification by IARC or US EPA
Reproductive Toxicity: Effects not fully studied
Target Organs: Kidneys, hearing system
Other Information: May cause antibiotic resistance with improper handling

Ecological Information

Ecotoxicity: Toxic to aquatic organisms at high concentrations
Persistence and Degradability: Not readily biodegradable, persistent in environment
Bioaccumulation Potential: Low based on molecular properties
Mobility in Soil: May contaminate groundwater due to solubility
Other Adverse Effects: Potential to promote development of antibiotic resistance in environmental bacterial populations

Disposal Considerations

Waste Disposal Methods: Collect and place unused material and contaminated packaging in marked containers for chemical waste; dispose through licensed hazardous waste contractor
Contaminated Packaging: Triple rinse, dispose as hazardous material
Special Instructions: Follow local, regional, and national regulations for disposal; avoid release to environment, never pour down drain or flush into sewage system

Transport Information

UN Number: Not assigned
Proper Shipping Name: Not regulated as hazardous for transport
Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Keep container tightly closed, avoid spillage during handling
Marine Pollutant: Not classified but avoid large releases into environment

Regulatory Information

OSHA Status: Considered hazardous by definition of Hazard Communication Standard
TSCA: Not listed
EU Regulation: Classified under Regulation (EC) No 1272/2008
Other Inventories: Not listed in Canadian DSL/NDSL or Australian AICS
Labeling Requirements: Follow applicable workplace and environmental labeling regulations
Restrictions: Veterinary use only; not for human use
SARA/Title III: Not subject to reporting requirements
California Proposition 65: Not listed