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Product Name: Gadotic Acid
Chemical Formula: C10H12GdN3O8
Synonyms: Gadolinium(III) 2,2',2''-(10-((2Z)-2-hydroxyimino-2-phenylacetamido)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
CAS Number: 66042-18-0
Intended Use: Pharmaceutical intermediate, medical imaging contrast agent
Manufacturer Information: Company address and emergency contact phone numbers are located on the product packaging.
Emergency Contact: Chemtrec (select regional hotline per manufacturer), local poison control.
GHS Classification: Skin irritation (Category 2), Eye irritation (Category 2A), Specific target organ toxicity – single exposure (Category 3)
Signal Word: Warning
Hazard Statements: Causes skin irritation, causes serious eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust or powder, use only outdoors or in a well-ventilated area, wash hands thoroughly after handling, wear protective gloves and eye/face protection, if swallowed: rinse mouth and get medical advice.
Hazard Symbols: Exclamation mark, Health Hazard
Chemical Identity: Gadotic Acid
CAS Number: 66042-18-0
Concentration: ≥98% as pure compound
Impurities and Additives: No hazardous impurities present above relevant thresholds.
Molecular Weight: 557.48 g/mol
Inhalation: Move affected person to fresh air, give oxygen if breathing is difficult, seek medical attention for persistent symptoms.
Skin Contact: Immediately wash skin using plenty of soap and water, remove contaminated clothing and shoes, seek medical advice if irritation persists.
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, keeping eyelids open, remove contacts if present and continue rinsing, seek medical care.
Ingestion: Rinse mouth thoroughly, drink two glasses of water, do not induce vomiting, obtain immediate medical attention.
Chronic Exposure: Continuous low-level exposure may cause organ effects; clinical monitoring advised.
Suitable Extinguishing Media: Water spray, foam, dry chemical powder, carbon dioxide
Unsuitable Media: Direct water jet (may spread material), avoid high-pressure sprays
Hazards from Combustion: Toxic fumes generated in fire including nitrogen oxides, carbon oxides, metal oxides
Protective Equipment: Firefighters use self-contained breathing apparatus, full protective clothing
Fire Precautions: Avoid inhalation of fumes, cool unopened containers exposed to fire with water spray, evacuate area as needed.
Personal Precautions: Wear protective gloves, goggles, lab coat, avoid dust generation; use NIOSH-approved respirator if needed
Environmental Precautions: Prevent leakage into drains, surface water, groundwater, soil
Cleanup Methods: Sweep or vacuum spilled powder using non-sparking tools, avoid creating dust clouds, collect in suitable waste container for disposal, ventilate area well, wash contaminated surfaces with detergent and water
Containment: If large spill, dike area to prevent run-off; notify authorities as required.
Safe Handling: Work in chemical fume hood, minimize dust, avoid breathing powder or aerosol, do not eat, drink, or smoke when handling, wash hands after use
Storage Conditions: Store in original tightly closed container, keep in cool, dry, well-ventilated location, avoid exposure to light and moisture
Incompatibilities: Strong oxidizing agents, strong acids, alkalis
Specific Precautions: Keep apart from foodstuffs, restrict access to trained personnel, prevent static accumulation by grounding.
Occupational Exposure Limits: No specific OELs established for gadotic acid; general nuisance dust limits: 10 mg/m³ (inhalable), 3 mg/m³ (respirable) recommended
Engineering Controls: Use with mechanical exhaust ventilation, safety shower and eyewash nearby
Personal Protection: Nitrile or rubber gloves, safety goggles, lab coat or coveralls, approved dust mask or respirator (N95 or P3 for particulates)
Hygiene: Remove clothing if contaminated, wash hands, forearms, and face thoroughly before breaks and at end of workday.
Physical State: Solid (powder or crystalline form)
Color: White to off-white
Odor: Odorless
Melting Point: Approximately 250°C (decomposes)
Boiling Point: Not determined
Solubility: Soluble in water (high), slightly soluble in methanol, insoluble in most organic solvents
pH (1% solution): 6–8
Vapor Pressure: Negligible
Density: 2.1–2.4 g/cm³
Partition Coefficient (log Kow): Not available
Flashpoint: Not applicable (non-flammable solid)
Stability: Stable under normal temperatures and pressures
Conditions to Avoid: Excess heat, moisture, incompatible materials
Incompatible Materials: Strong oxidizers, strong acids and bases, reactive metals
Hazardous Decomposition Products: Combustion yields carbon monoxide, carbon dioxide, nitrogen oxides, metal oxides
Polymerization: Will not occur under recommended handling and storage conditions.
Acute Toxicity: Oral LD50 (rat): >2000 mg/kg; may cause mild gastrointestinal upset if ingested
Skin Irritation: May cause redness, itching, dryness
Eye Damage/Irritation: Severe eye irritant; potential for conjunctivitis, tearing, blurred vision
Respiratory Irritation: Dust may irritate nose, throat, and upper respiratory tract
Chronic Effects: Prolonged or repeated exposure can impact liver, kidneys due to gadolinium retention; no evidence of mutagenicity or carcinogenicity in current literature
Sensitization: Not known to cause sensitization
Other Information: Medical surveillance recommended for occupational exposure.
Toxicity to Aquatic Life: Gadolinium complexes may be hazardous to aquatic organisms in high concentrations
Persistence and Degradability: Likely persistent in soil and water, does not degrade readily
Bioaccumulative Potential: Low to moderate; gadolinium can accumulate in aquatic environments
Mobility in Soil: Moderate; potential to migrate depending on environmental conditions
Other Adverse Effects: Monitor wastewater and effluent for containment of gadolinium residues.
Disposal Methods: Collect material in properly labeled container, follow local, regional, and national regulations for chemical waste; do not flush into waterways, drains or sewers
Contaminated Packaging: Triple rinse containers, puncture, and dispose of as hazardous waste
Special Precautions: Secure, transport, and store waste separately until it can be collected by licensed disposal contractor.
UN Number: Not classified as hazardous for transportation (DOT, IATA, IMDG)
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Labeling Requirements: None required beyond standard chemical labeling for sample/package identification
Transport Precautions: Ship in sealed, intact packaging, secure against movement, avoid spill and breakage in transit.
TSCA Status: Listed or exempt
REACH Status: Registered or pre-registered (Europe)
OSHA: Meets criteria as hazardous chemical
SARA Title III: Not listed as an Extremely Hazardous Substance; not subject to Sections 302, 304, 311, 312, 313
California Proposition 65: Not listed
Other Regional/International Regulations: Ensure compliance with specific local, national, and international requirements for handling gadolinium compounds.
Workplace Controls: Follow appropriate regulatory guidelines for personal exposure and environmental discharge.
