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Product Name: Fenbendazole
Chemical Name: Methyl 5-(phenylthio)-2-benzimidazolecarbamate
Synonyms: Fenbantel, Safe-Guard, Panacur, Rintal
CAS Number: 43210-67-9
Recommended Use: Anthelmintic (dewormer) for veterinary applications
Supplier: Contact details of manufacturer or distributor should be accessed from package label or supplier database
Emergency Contact: Obtain national poison center contact and supplier response line from product packaging
GHS Classification: Not classified as hazardous under GHS for most supplied forms
Physical Hazards: May form dust; risk of dust explosion under severe conditions
Health Hazards: Potential mild eye and skin irritant, ingestion of large amounts can lead to gastrointestinal upset, not a confirmed carcinogen
Environmental Hazards: Harmful to aquatic life during spills or improper disposal
Signal Word: Warning (based on regional hazard labels)
Hazard Statements: May cause mild respiratory irritation if inhaled as dust, can cause discomfort to the eyes or skin on direct or prolonged contact
Pictograms: Exclamation mark for skin/eye/respiratory irritation possible
Chemical Component: Fenbendazole
Concentration: 98-100% (Technical grade), variable for commercial preparations
Impurities/Additives: Trace residues from synthesis, stabilizers in formulated products
Molecular Formula: C15H13N3O2S
Molecular Weight: 299.35 g/mol
Other Ingredients: Filler, binder, and carrier if supplied as premix or finished dosage forms
Relevant Exposure Limits: None established specifically for fenbendazole
Eye Contact: Flush gently with lukewarm water for 15 minutes, remove contact lenses, seek medical attention if irritation persists
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, consult a doctor if rash or irritation develops
Ingestion: Rinse mouth, provide water if conscious, seek medical advice especially if large amounts swallowed or patient feels unwell
Inhalation: Move person to fresh air, keep warm and at rest, consult physician if symptoms such as coughing or dizziness present
Note to Physicians: Treat symptomatically; no specific antidote
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Strong water jets (may spread powder)
Special Hazards: Combustion may generate nitrogen oxides, sulfur oxides, carbon monoxide and dioxide, possible toxic fumes
Protective Equipment: Self-contained breathing apparatus, full protective gear
Firefighting Instructions: Avoid inhalation of smoke, cool exposed containers with water, prevent runoff from entering waterways
Personal Protection: Wear gloves, goggles, suitable dust mask or respirator, long sleeves
Spill Cleanup: Avoid dust formation, sweep up or vacuum without creating dust, collect in appropriate containers for disposal
Environmental Precautions: Keep spills away from drains, surface water, and soil, alert authorities if significant contamination risk exists
Disposal of Cleanup: Seal in labeled containers, handle via licensed chemical waste handler
Decontamination: Clean spill area thoroughly with water and detergent to reduce residue
Handling: Use with adequate ventilation, minimize dust generation and accumulation, avoid contact with eyes, skin and clothing, do not eat or drink while handling
Storage: Store in original labeled container tightly closed, keep in cool dry area out of direct sunlight
Storage Temperature: Recommended below 30°C (86°F)
Incompatibility: Avoid strong acids, bases and oxidizing agents
Segregation: Keep away from food, feedstuffs, beverages, and incompatible substances
Engineering Controls: Employ local exhaust or general ventilation
Personal Protective Equipment (PPE): Dust-proof goggles, protective gloves, respirator (NIOSH-approved for particulates) when airborne dust present, lab coat or coveralls
Hygiene Practices: Wash hands thoroughly after handling; avoid reusing contaminated clothing without cleaning
Exposure Limits: No workplace exposure limits set for fenbendazole; maintain exposure as low as possible
Appearance: White to off-white crystalline powder
Odor: Odorless or faint phenolic odor
pH: Not applicable in solid form; low solubility in water
Melting Point: 233-234°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable/available (non-volatile solid)
Solubility: Poor in water (less than 10 mg/L), solubility increases in organic solvents like DMSO
Density: 1.37 g/cm³
Partition Coefficient (log Kow): 3.8-4.0
Vapor Pressure: Negligible
Other Properties: Stable under ambient conditions, sensitive to light for long durations
Chemical Stability: Stable under normal temperatures and recommended storage conditions
Reactivity: Minimally reactive; not prone to hazardous polymerization
Conditions to Avoid: Excessive moisture, strong light, heat sources
Incompatible Materials: Strong acids, strong bases, oxidizing substances
Hazardous Decomposition: Carbon oxides, nitrogen oxides, sulfur oxides on thermal decomposition
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Toxicity (LD50): Oral LD50 in rats above 2000 mg/kg, relatively low toxicity to mammals
Local Effects: Mild irritation possible for eyes and skin at high concentrations
Chronic effects: High doses in animal studies linked to reversible changes in the liver, no clear link to cancer or reproductive toxicity at occupational exposure levels
Sensitization: No confirmed evidence for respiratory or skin sensitization
Mutagenicity & Carcinogenicity: No evidence of mutagenicity/carcinogenicity in standard animal tests
Aquatic Toxicity: Harmful to aquatic organisms, especially with large acute releases
Persistence and Degradability: Moderately persistent, degradation in soil and sediment via microbial breakdown
Bioaccumulation: Moderate risk according to log Kow; potential for accumulation in aquatic species
Mobility in Soil: Low water solubility limits mobility; adsorbs moderately to soils
Ecotoxicity Test Data: LC50 for fish and aquatic invertebrates typically above 1 mg/L
Product Disposal: Dispose via licensed hazardous waste handler in accordance with local, state, and federal environmental regulations
Container Disposal: Triple-rinse containers, puncture and dispose as hazardous chemical packaging
Precautions: Do not release untreated into sewers, waterways, or environment
Disposal Methods: Incinerate if permitted and technically feasible, or deposit in licensed landfill
UN Number: Not assigned for technical Fenbendazole
Proper Shipping Name: Non-regulated for ground, sea, air transport under most jurisdictions
Transport Hazard Class: Not classified as hazardous under ADR, RID, IMDG, IATA
Packing Group: Not assigned
Special Precautions: Protect from moisture and physical damage during transport; avoid extremes of temperature
Regulatory Status: Not classified as a hazardous chemical under most GHS-aligned frameworks
TSCA (USA): Listed
REACH (EU): Registered substance
Other National Inventories: Australia (AICS), Canada (DSL), Japan (ENCS), South Korea (KECI), China (IECSC)
Occupational Classification: No workplace exposure standard set for Fenbendazole
Other Regulatory Information: Veterinary pharmaceutical regulations apply for use and distribution, environmental releases restricted under pesticide guidelines in many regions
