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Ethylenediaminetetraacetic Acid Tetrasodium Salt (EDTA-4NA): Beyond the Basics

Historical Perspective: Scientific Curiosity to Industrial Mainstay

EDTA-4NA didn't arrive on the scene by accident. Early researchers, eyeing the need for chemical alternatives to naturally derived citrates, began searching for powerful agents that could tame metal ions in water and industry. In my own research career, I’ve seen countless references to the original work in the mid-20th century. Chemists understood that naturally occurring solutions just couldn’t keep pace with the tide of metals flooding into water systems with the dawn of widespread industrialization. Paul Ferdinand, a German chemist, first synthesized EDTA, and soon after, tetrasodium salt emerged as a more soluble, workable form for applied uses. The adoption of EDTA-4NA soared as the complexity of manufacturing rose, especially post-WWII. Today, its legacy rests on a pragmatic ability to deliver cleaner water, purer foods, and more reliable lab results.

Product Overview: More Than Just a Chelating Agent

At its core, EDTA-4NA grabs hold of metal ions and keeps them from interfering with reactions. The business of chelation matters far beyond test tubes. In water treatment plants, I’ve watched operators face the challenge of stubborn heavy metals that disrupt purification processes. EDTA-4NA swept in with a simple promise: tie up those ions, keep them from gumming up the works, protect infrastructure. This role extends into personal care, food, and pharmaceutical industries. Chelation means cleaner cosmetics, longer-lasting canned goods, and drugs that don’t degrade on the shelf. These outcomes shape daily life, though few consumers recognize the chemistry churning beneath the surface. The influence of EDTA-4NA isn’t locked away in technical manuals — it spills into how safely we eat, bathe, and heal.

Physical & Chemical Properties: Applied Science in Action

EDTA-4NA holds its own as a white, crystalline, highly soluble compound. In the lab, I’ve handled it in large drums before it’s dissolved into catching heavy metals. The tetrasodium form gives it a neutral pH in water, important for applications where acid-base balance determines whether a process succeeds or fails. With four sodium atoms replacing the acidic hydrogens, this form jumps into solution much more readily than other EDTA variants. That means process engineers or plant operators don’t need to wrestle with slow dissolving powders during batch mixing, or worry about corrosive side-effects. This chemical also resists breakdown across a wide temperature range, a must for rugged industrial environments. Its robust chelation, particularly for divalent and trivalent metals like calcium, magnesium, and iron, backs up its popularity. That’s not just textbook knowledge — it’s the difference between functional equipment and production delays.

Technical Specs & Labeling: Making Practical Choices with Real Impacts

In daily operations, I’ve seen how purity, concentration, and labeling become more than box-checking exercises. High-purity EDTA-4NA makes a clear difference in sensitive applications. If you’re running trace metal analysis, any contaminant warps the results, so suppliers must offer verifiable specifications. Typical industrial labels focus on percent purity, intended use, and batch numbers. Lab staff and plant managers lean heavily on these details to comply with internal policies and external regulations. Also, the physical form — be it powder or granule — changes handling considerations, from dust control to dissolution rates. These aren’t minor details for everyday users. A mislabelled drum or a subpar batch can trigger expensive production overruns or regulatory scrutiny, making granular information about the chemical as important as the compound itself.

Preparation: How EDTA-4NA Comes to Be

Manufacturing EDTA-4NA starts with ethylenediamine and chloroacetic acid under alkaline conditions, producing EDTA, which is then neutralized with sodium hydroxide to make the tetrasodium salt. This procedure might look straightforward in chemical equations, but the industrial view tells another story. Bulk processing introduces hurdles from temperature control to waste management. Alkaline production environments need robust safeguards since sodium hydroxide doesn’t play nicely with skin or eyes. In my own labs, I found the greatest challenges arise during the neutralization step, which produces heat and can lead to quick crystallization if not closely watched. Large-scale operators have to stay vigilant about emissions, effluent treatment, and consistency across thousands of kilograms of product every month. The preparation pathway, refined over decades, reflects more than chemistry — it’s a lesson in scaling safely and reliably.

Chemical Reactions & Modifications: Flexibility and Customization

EDTA-4NA brings impressive stability, but its chemical structure welcomes modification for specialty uses. This versatility underpins unique commercial and scientific projects. I've been involved in customizing chelators for diagnostic reagents, swapping functional groups to target metals with greater selectivity. Other industries adjust the sodium balance or introduce co-chelators for dirtier or more variable water supplies. EDTA-4NA’s sodium content means it holds up in alkaline environments, unlike the acid forms, making it indispensable for textile and pulp cleaning lines. Reactivity toward metal ions remains its star trait, but it also engages in crosslinking reactions, offering paths to modified resins or membrane materials. The open canvas of EDTA chemistry keeps research labs engaged and new patents rolling in year after year.

What’s In a Name? Synonyms & Product Aliases

Ask for EDTA-4NA, and you might just get “tetrasodium EDTA,” “Ethylenediaminetetraacetic acid tetrasodium salt,” or an alphabet-soup of chemical numbers. In operations, ensuring the right material shows up can be a struggle. During procurement hiccups, I’ve seen shipments of disodium EDTA arrive instead — similar enough at first glance, but wrong for the job. These synonyms matter not only for purchasing but for legal compliance. Regulatory filings, exports, and safety documents often demand precise, internationally standardized names. Whether working at a small research startup or a large manufacturing plant, using clear terms sets the stage for safer, easier logistics.

Safety & Operational Standards: Daily Hazards and Long-Term Awareness

EDTA-4NA builds its reputation on reliability, though working with chemicals of any kind means respecting risk. The main exposures on-site come from dust inhalation or accidental contact during mixing, especially in poorly ventilated spaces. Wearing gloves, goggles, and masks isn’t an option — it’s standard operating procedure. Sodium salts can irritate the skin and mucous membranes, and spill management requires prompt response. Disposal protocols come under strict review because EDTA—by binding up trace metals—can strip nutrients from soil and aquatic systems if mishandled. In regulated industries, failure to observe established standards can lead to sanctions or operational shutdowns. Personally, I’ve watched teams invest in routine safety trainings when their inventory includes EDTA-4NA, reinforcing that chemical management isn’t a background issue. Responsible handling means sustained vigilance, regular audits, and honest communication about risks.

Application Area: Driven by Real-World Demand

Trace EDTA-4NA across industries and the real impact becomes clear. In water treatment, it strips out calcium and magnesium, softening supplies so pipes don’t scale up and families get clean water. Textile and pulp sectors lean on it to prevent stains and guarantee whiteness in finished goods. Laboratory applications thrive because EDTA-4NA doesn’t interfere with most analytical techniques. Food processors rely on it to keep color, flavor, and texture in packaged products, especially canned vegetables that might lose vibrancy over time. Even pharmaceutical manufacturing reserves a corner for this chelating agent — stabilizing medicines vulnerable to trace metals. Over years in the lab, I’ve grown to respect how quickly a missing or substituted chelator can disrupt results. The reach of this salt works as a behind-the-scenes assurance that quality persists where less visible variables threaten to undo careful planning.

Innovation & Research: New Questions, New Solutions

EDTA-4NA’s ubiquity hasn’t dulled curiosity about its limits or new behaviors. Ongoing research digs into how it interacts with emerging contaminants and if environmental impacts can be minimized through structural tweaks. I recall a project at a municipal water lab probing if modified chelators could capture lead and arsenic more efficiently, hoping to meet new low-level detection limits set by regulators. Advances in analytical instrumentation push scientists to refine chelator formulations, creating more specific, less intrusive blends for sensitive processes like enzyme assays and chromatographic separations. These inquiries demand partnerships between academia, industry, and government — all looking not just to make things work, but to remake them for a world with stricter standards and finer measurements.

Toxicity & Environmental Research: Balancing Utility and Impact

No chemical stands outside scrutiny, especially one as widespread as EDTA-4NA. While acute toxicity seems modest, environmental scientists keep an eye on how extensive usage affects ecosystems. The main concern circles around the ability of EDTA to ferry metals through soils and waterways. In my own explorations of environmental chemistry, I’ve seen studies track the movement of chelated metals, measuring impacts on plant uptake and aquatic health. The molecule can mobilize contaminants, challenging cleanup efforts in polluted zones. Research points to a need for tighter discharge controls, better effluent treatment, and alternatives that break down more easily outside industrial processes. Regulatory agencies across continents have justified calls for restriction reviews, not because EDTA-4NA is inherently hazardous, but because its action magnifies existing environmental vulnerabilities. These cautionary tales underscore how necessary it is to align utility with ecosystem health.

Forward Look: What’s Next for EDTA-4NA?

EDTA-4NA stands as a fixture, though not immune to change. The chemical industry moves with global demand for green and biodegradable alternatives, taking on more challenges as regulations toughen. I’ve spoken with researchers aiming for the next generation of chelators, promising the same reliability with less environmental baggage. Some advocate for closed-loop usage, recycling chelators in treatment facilities rather than flushing them away. Others push for hybrid molecules designed to lose chelating power once their job finishes, curtailing the risk of unintended transport in groundwater or effluent. Whether through smarter engineering or policy shifts, the future demands coordination between performance and responsibility. End-users, from municipal engineers to pharmaceutical scientists, lean on solid, trustworthy tools but remain open to better approaches. The story of EDTA-4NA unfolds as one of adaptability — where practical utility meets evolving expectations for stewardship and safety.




What is Ethylenediaminetetraacetic Acid Tetrasodium Salt (EDTA-4NA) used for?

Breaking Down the Role of EDTA-4NA

Ethylenediaminetetraacetic Acid Tetrasodium Salt—EDTA-4NA—might sound like something that only belongs in a laboratory, but I have seen its impact outside of the lab too. At work, I ran across this chemical during a stint in water treatment, and that’s when I started noticing it popping up everywhere from cleaning products right back to the medical field. EDTA-4NA works as a chelating agent, which really means it grabs onto metal ions and keeps them out of trouble. Metals like calcium and magnesium do more than just harden water; they clog up pipes, weaken detergents, and can cause some nasty stains.

Companies lean on EDTA-4NA for water softening. My family lives in a region with hard water, so seeing this ingredient in cleaning agents wasn’t a surprise. Adding it helps the soaps do their job, which cuts down on the amount of detergent we need. It saves money and keeps our pipes in better shape. I’ve tossed out less-stained laundry since I started paying attention to which products use EDTA-4NA.

The Silent Hero in Cleaning and Industry

In most dishwashing tablets and laundry powders, you’ll find EDTA-4NA doing heavy lifting behind the scenes. Trapping metal ions from water makes for cleaner dishes and brighter clothes. Looking deeper, factories and labs use this chemical as well. In metal plating or as part of industrial cleaners, it keeps machines running longer and stops rust or unwanted deposits. Without it, machinery needs more maintenance, and processes slow down.

I once toured a textile mill that struggled with mineral stains on fabrics before switching their detergents to a formula with EDTA-4NA. I saw fewer rejects in their product line, and the company cut their water usage since they weren’t battling hard water deposits. Instead of swapping out expensive equipment, they just improved their chemistry. That speaks to the kind of everyday difference this chemical delivers.

Healthcare and Food Additive Roles

Hospitals and blood banks rely on EDTA-4NA too. It keeps blood samples from clumping up so lab results stay accurate. In medicine, they also use this ingredient to treat heavy metal poisoning, sidestepping some dangerous side effects. In food, you’ll see it listed under additives that prevent spoilage, as it stops metal ions from triggering reactions that take color and flavor out of preserved goods.

Reading about this brought me back to memories of my grandmother storing pickles that kept their crunch and color. She might not have read the label, but modern brands often add compounds like EDTA-4NA to keep things fresh longer. Consumers get less waste and better taste.

Balancing Safety and Environmental Questions

With EDTA-4NA turning up in so many corners of life, safety does cross my mind. The compound generally checks out in terms of toxicity for typical household use. Long-term buildup in waterways has raised concerns for fish and other aquatic life, according to the European Chemicals Agency and the US Environmental Protection Agency. Some countries ask companies to refine their wastewater or explore alternatives.

Promoting greener alternatives and educating manufacturers on responsible discharge has started to curb some risks. These steps suggest progress, but manufacturers, governments, and consumers still have a part to play. Keeping an eye on what’s in cleaning supplies or processed foods might not seem like much, but choices add up.

Is EDTA-4NA safe for use in food and cosmetics?

What Is EDTA-4NA, and Where Do You Find It?

A lot of people might not recognize the name EDTA-4NA, but it shows up often in ingredient lists. You get it from ethylenediaminetetraacetic acid that’s been mixed with sodium, making it soluble. Food and cosmetics rely on it to keep colors stable and protect products from spoiling. You’ll catch it in canned beans so they don’t turn brown, and in face creams where it helps stop metals from damaging sensitive formulas.

Is EDTA-4NA Safe for Eating?

Regulators like the FDA and the European Food Safety Authority give EDTA-4NA a stamp of approval—but with rules. The FDA sets a daily limit: 2.5 milligrams per kilogram body weight. That means you'd have to consume a lot of it by accident to get close. Scientific studies point out that common food levels aren’t enough to be toxic. Rats fed large doses got sick, but the amounts used in snacks or spreads stay about a hundred times smaller than those risky doses. Many food scientists also keep tabs on manufacturers, making sure they measure exact amounts.

Cosmetics and Skin Contact

People with sensitive skin often worry about preservatives and additives. Dermatologists see allergy cases from fragrances and certain preservatives, but reports about irritation from EDTA-4NA don’t come up much. Lab studies show minor to no irritation, even for folks with a history of skin troubles. Still, relying on patch tests can help those especially worried. Cosmetic scientists focus on safety, because any product that stings could lose trust or cause recalls. Consumer products giants have a habit of reviewing safety data almost yearly, responding to new research or shifts in public concern.

Why Use It At All?

Without stabilizers like EDTA-4NA, canned or bottled foods would brown, dairy would curdle, and lotions would turn gritty or foul-smelling. Natural alternatives don’t always last as long or cost as little. Big groups like the World Health Organization list it among food additives that keep people from getting sick from spoiled goods. In my own pantry, products with this ingredient last longer—and none of my family has gotten ill from a can of beans yet.

Could There Be a Downside?

Overuse always has consequences. Too much EDTA-4NA in sewage or runoff can harm rivers by picking up metals and releasing them into water. Regulators in Europe pushed for limits on industrial disposal after noticing spikes in water pollution. In the US, food and cosmetic makers know they have to watch their waste streams. Consumers also ask for fewer synthetic additives each year. Reading labels and pushing companies to limit chemical use won’t hurt.

What Would Make It Safer?

Better transparency from food brands would help. Publishing test results and sources of additives lets anyone see what they’re eating or putting on their skin. Labs already check for heavy metals and other contaminants, so extending that to additives brings more peace of mind. More investment in plant-based chelators could drive down costs for alternatives, since the main hold-up stays financial for many companies. At home, staying informed and rarely relying on processed or canned goods cuts exposure far more than any government policy could.

How should EDTA-4NA be stored and handled?

Understanding What’s At Stake

EDTA-4NA often shows up in industries from pharmaceuticals to water treatment. It chelates metals, helping purify and stabilize products. Its popularity isn’t about hype—it’s about influence and reliability. Because of its trustworthiness in sensitive processes, handling it properly matters. Mishandling leads to unnecessary safety issues, costly waste, or ruined materials. I’ve seen cases where lack of oversight in chemical storage led to accidents. Those situations don’t build trust or save money.

Common Sense Handling Makes the Difference

EDTA-4NA comes as a powder or crystalline solid. It doesn’t explode or release dangerous fumes in air, but the real danger comes from underestimating it. Small particles can get airborne. Working without suitable gloves or goggles means giving skin and eyes an open invitation to irritation. I’ve watched experienced staff let their guard down, thinking a “mild” chemical couldn’t bite back. After one too many complaints about itching or eye redness, most learned not to skip basic protective gear.

Good laboratory or workshop habits set the tone. Keep food and drinks out of work areas, and don’t use hands to brush spills off benches. Keeping a tidy station doesn’t just look professional—it reduces contamination risk. Simple routines make all the difference: wearing a dust mask while measuring powders, double-checking that containers are closed before leaving, and labeling everything for the next shift.

Smart Storage: Not Complicated, Just Crucial

Humidity and light both threaten EDTA-4NA’s shelf life and effectiveness. If left unsealed or stacked in a damp room, this chemical absorbs water from air and clumps together. Storing it in an airtight container in a dry place saves both time and money. There’s no magic to this—it’s the same principle behind keeping coffee fresh. Direct sunlight can degrade it, so a dark cupboard or opaque bin makes sense.

Stores and labs should always separate EDTA-4NA from acids and oxidizers. Mixing becomes risky since reactions between chemicals can create hazardous situations. I’ve heard stories of people taking shortcuts by placing everything on one shelf, only to regret it after an unplanned cleanup. Fire codes and workplace rules weren’t invented for decoration—they were born out of hard-earned experience.

Spills Aren’t the End of the World—If You’re Ready

Accidents happen, even among veterans. Quick, calm responses keep things under control. If someone spills EDTA-4NA, clear the area, avoid kicking up dust, and use a careful sweep or HEPA vacuum. Dumping it down the drain creates environmental headaches. People underestimate how small mistakes travel downstream. A dedicated chemical waste bin solves more problems than it creates.

Long-Term Health Means Thinking Ahead

Regular training makes handling easier. Even small safety updates help avoid careless mistakes. At one of my earlier jobs, we set up quarterly workshops to review chemical hazards and emergency readiness. Over time, near-misses dropped, and so did workplace injuries.

EDTA-4NA isn’t the most dangerous compound in the cabinet, but treating it casually creates unnecessary risks. Responsible storage and solid handling habits cost nothing extra but pay off with reliability, safety, and peace of mind for everybody involved.

What is the typical concentration or dosage of EDTA-4NA in applications?

EDTA-4NA in the Real World

EDTA-4NA, short for ethylenediaminetetraacetic acid tetrasodium salt, pops up across industries, especially in water treatment, cleaning products, and pharmaceuticals. In my work with water quality testing in a small municipal utility, I saw EDTA-4NA put to use often, chosen for its power to grab onto metal ions. It showed its value every day, helping keep drinking water clear of unwanted minerals like iron or calcium.

This chemical works because it binds metal ions, almost like a magnet you can control. The outcome: water that doesn’t leave stains on dishes and pipes that stay free of hard deposits.

Standard Dosages Across Different Applications

Water treatment plants usually rely on concentrations from 0.01% up to about 0.2% EDTA-4NA by weight. That translates to 100 to 2,000 milligrams per liter in practical terms. The sweet spot often lands at 0.05% to 0.1% for general-scale municipal use. My time chatting with engineers at several cities confirmed they stick to these smaller doses for budget and safety. Going higher rarely boosts performance and just runs up chemical bills.

In industrial cleaning—think food-processing tanks or metal equipment—concentrations climb. Here, shampoos and sprays can reach 0.5% or even 2%, especially for heavy-duty descaling tasks or for cleaning stainless steel. Chemists in manufacturing shared that too much EDTA-4NA can cause more trouble than it solves, such as risking environmental discharge violations. They monitor levels carefully, tweaking the mix as needed based on how dirty that day’s batch of tanks gets.

Pharmaceuticals set strict rules. Injectable medicines stay well under 0.1%, often as little as 0.005%. These micro-doses keep medicine stable without causing harm. Safety guidelines from groups like the World Health Organization and the US Pharmacopeia act as guardrails. Too much can pull important minerals from the body, so careful math underpins every batch.

Why Dose Matters—Lessons Learned

Getting the dosage wrong wastes more than money; it can cause compliance headaches. I’ve seen engineers spend weeks rebalancing a treatment plant’s chemistry after pushing EDTA-4NA concentrations too high. Farmers using chelated micronutrients in crops, for example, lean on lower concentrations (often around 0.01%) to avoid leaching nutrients into streams.

Environmental regulators pay close attention to these numbers. Wastewater rules remain tight because EDTA-4NA sticks around, carrying metals with it. Research from the European Chemicals Agency notes that improper management can let EDTA-and-metal combos slip into rivers, where they threaten aquatic life. Experience shows that too much chelant doesn’t just fix one problem—it hands you two new ones.

Smarter Solutions Going Forward

EDTA-4NA works best when labs fine-tune dosage based on water quality tests, not rough guesswork. Keeping levels just high enough saves money and helps the planet. Some plants now automate dosing, calibrating the chemical flow in real time. Field trials suggest this approach uses up to 30% less EDTA-4NA with no drop in water quality.

Wastewater recovery systems catch used EDTA-4NA, letting some factories recycle. Several forward-thinking companies now partner with universities to develop biodegradable alternatives with similar metal-grabbing skills. Until these new options reach scale, industry veterans recommend regular audits on dosage rates—comparing test results and adjusting practices.

EDTA-4NA’s dosage depends on who uses it and why, but safe, effective use always starts with careful measurement and respect for both science and the wider world—lessons learned in the lab, on the job, and in the field.

Does EDTA-4NA have any known side effects or hazards?

Understanding EDTA-4NA and Its Everyday Uses

EDTA-4NA finds its way into a surprising number of products, from household cleaners and cosmetics to pharmaceuticals and food processing. People turn to it for its ability to chelate, or "grab hold" of, metal ions. In everyday terms, this makes it useful for preventing discoloration, extending shelf life, cleaning surfaces, or stabilizing formulations.

Potential Hazards and Human Exposure

No chemical comes without some risk, and EDTA-4NA is no exception. Most scientific literature considers it low in toxicity for humans, but repeated or high-level exposure brings up some concerns. For starters, skin or eye contact with undiluted EDTA-4NA powder or solution can cause irritation. A splash in the eye stings; a dusting on the hands can bring redness, itching, or even a rash for sensitive folks.

Breathing in the powder won’t do the lungs any good—workers around bulk EDTA-4NA need masks and ventilation. I remember seeing safety sheets recommending goggles and gloves for anyone mixing or pouring it. Such guidelines come from real-world mishaps: reports of sneezing fits, mild coughing, or rare cases of brief breathing trouble for people in industrial settings. Accidental swallowing happens very rarely, but large amounts can upset the stomach, sometimes leading to cramps or diarrhea. These symptoms fade as soon as the substance leaves the system.

Environmental Impact and Wider Concerns

People may forget that washing something down a drain doesn’t mean it vanishes. EDTA-4NA moves through wastewater and holds onto heavy metals, which means it can drag contaminants into rivers or soil. Some studies link high concentrations to trouble for fish or aquatic organisms. In Europe, regulators track how much gets released and encourage companies to limit runoff.

For households, the risk looms small if products follow typical use instructions. Problems loom larger in areas near factories or laboratories, where careless disposal piles up and local water or sludge gets loaded with the chemical.

Long-Term Health Questions

EDTA-4NA enters the bloodstream in medical settings under strict supervision, usually to treat lead poisoning. Here, doctors watch for effects, because this compound doesn’t just capture bad metals—it also grabs the good ones. If doses go too high or treatments go on too long, people can lose important minerals like calcium, potassium, or magnesium, which upsets the body in ways that can range from muscle cramps to heart trouble.

Research on cancer risk or links to birth defects has not found anything definitive in humans. No large-scale studies blame EDTA-4NA for such effects. Guidelines recommend limiting use with young children, and I always appreciated seeing extra caution boxes on medical forms or packaging.

Practical Solutions and Smarter Handling

Anyone using EDTA-4NA at home should store it out of reach of children and follow directions. Workers at plants or labs use local exhaust fans, protective clothing, and training on what to do if a spill happens. Environmental groups urge manufacturers to switch to less persistent or more biodegradable agents where possible.

Simple steps—labeling containers, rinsing skin at the first sign of irritation, or checking if your city has restrictions on disposal—make a big difference in lowering risk. Feedback from responsible companies, proper oversight, and public awareness help keep EDTA-4NA a helpful tool instead of a hidden danger.

Ethylenediaminetetraacetic Acid Tetrasodium Salt (EDTA-4NA)
Names
Preferred IUPAC name tetrasodium (2S,2'S,2''S,2'''S)-2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
Other names EDTA Tetrasodium Salt
Ethylenediaminetetraacetic Acid Tetrasodium Salt
Tetrasodium EDTA
EDTA-Na4
EDTA TetraSodium
EDTA-4Na
Ethylenedinitrilotetraacetic acid tetrasodium salt
Pronunciation /ˌɛθ.ɪˌliːn.daɪˌæm.ɪn.tɛtrə.əˈsiː.tɪk ˈæs.ɪd ˌtɛtrəˈsoʊ.di.əm sɔlt/
Identifiers
CAS Number 13235-36-4
3D model (JSmol) `3D model (JSmol) string` for Ethylenediaminetetraacetic Acid Tetrasodium Salt (EDTA-4NA): ``` MUZTBYQXHHHONC-UHFFFAOYSA-J ``` *(This is the JSmol-compatible InChIKey string for EDTA tetrasodium salt.)*
Beilstein Reference 1710409
ChEBI CHEBI:61377
ChEMBL CHEMBL1200851
ChemSpider 64774
DrugBank DB04244
ECHA InfoCard 03bab8b6-e273-41b9-b57a-8c21e808318c
EC Number 200-573-9
Gmelin Reference 18721
KEGG C01780
MeSH D000071230
PubChem CID 87615195
RTECS number AH4025000
UNII R71W295H3L
UN number “3077”
CompTox Dashboard (EPA) Q409503
Properties
Chemical formula C10H12N2Na4O8
Molar mass 380.17 g/mol
Appearance white crystalline powder
Odor Odorless
Density Density: 1.01 g/cm³
Solubility in water Soluble in water
log P -4.3
Vapor pressure <1 mmHg (25°C)
Acidity (pKa) 10.3
Basicity (pKb) 11.0
Magnetic susceptibility (χ) -13.6×10⁻⁶ cm³/mol
Refractive index (nD) 1.409 (20°C)
Viscosity <100 cP (25°C, 20% in H2O)
Dipole moment 7.78 D
Thermochemistry
Std molar entropy (S⦵298) Std molar entropy (S⦵298) of Ethylenediaminetetraacetic Acid Tetrasodium Salt (EDTA-4NA)
Pharmacology
ATC code V03AB03
Hazards
Main hazards Causes serious eye irritation. May cause respiratory irritation. May cause skin irritation.
GHS labelling GHS07, GHS05
Pictograms GHS07,GHS05
Signal word Warning
Hazard statements H302 + H312 + H332: Harmful if swallowed, in contact with skin or if inhaled.
Precautionary statements P264, P270, P305+P351+P338, P337+P313, P301+P330+P331, P501
NFPA 704 (fire diamond) 1-0-0
Flash point > 230°C (446°F)
Autoignition temperature 335°C
Lethal dose or concentration LD50 (Oral, Rat): 10,000 mg/kg
LD50 (median dose) > 1,650 mg/kg (Rat, oral)
NIOSH QU2450000
PEL (Permissible) PEL: Not established
REL (Recommended) 30 mg/kg bw/day
IDLH (Immediate danger) Not established
Related compounds
Related compounds Ethylenediaminetetraacetic acid (EDTA)
Disodium EDTA (EDTA-2Na)
Trisodium EDTA (EDTA-3Na)
Calcium disodium EDTA
Iron(III) EDTA
Potassium EDTA
EDTA dianhydride