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Product name: Ethionamide
Chemical formula: C8H10N2S
CAS Number: 536-33-4
Synonyms: 2-Ethylpyridine-4-carbothioamide, Trecator
Recommended use: Pharmaceutical ingredient, primarily for tuberculosis
Supplier information: Manufacturer address with emergency contact phone number available on the product label or from the distributor
Use restrictions: Not for household or veterinary use
Classification: Acute toxicity (oral, inhalation), Skin sensitization, Eye irritation, Target organ toxicity
Hazard statements: Toxic if swallowed, causes skin and serious eye irritation, may cause allergic skin reactions, may damage liver or thyroid on prolonged use
Pictograms: Skull and crossbones, exclamation mark, health hazard
Precautionary statements: Avoid breathing dust, wash hands thoroughly after handling, wear gloves, protective clothing, eye and face protection, do not eat, drink or smoke while handling
Chemical name: Ethionamide
Concentration: 98–100%
Impurities: No significant impurities above regulatory thresholds
Other components: No additional hazardous ingredients
Inhalation: Move person to fresh air, keep comfortable for breathing, get medical attention immediately
Skin contact: Remove contaminated clothing, rinse skin with water and soap, consult medical advice if irritation develops
Eye contact: Rinse carefully with water for at least 15 minutes, remove contact lenses if present, seek medical attention quickly
Ingestion: Rinse mouth, do not induce vomiting, get prompt medical attention
Antidote: No specific antidote, symptomatic and supportive treatment only
Suitable extinguishing media: Carbon dioxide, dry chemical powder, alcohol-resistant foam, water spray
Specific hazards: Vapors may form hazardous mixtures with air, combustion may release toxic fumes such as nitrogen oxides, sulfur oxides
Protective equipment: Firefighters wear self-contained breathing apparatus and full protective gear to prevent skin and eye contact
Special procedures: Remove containers from fire area if safe, prevent run-off from entering drains or water sources
Personal precautions: Evacuate unnecessary personnel, ventilate area, wear protective equipment including gloves, mask, goggles
Environmental precautions: Prevent further leakage or spillage, do not allow to enter drains, surface or ground water
Cleaning methods: Collect solid material using HEPA-filtered vacuum or damp sweeping, place in an appropriate disposal container, decontaminate area with suitable detergent
Handling: Avoid all direct contact with substance, use only in well-ventilated area or fume hood, wear recommended personal protective equipment, prevent dust formation, follow good industrial hygiene practices
Storage: Store locked up in tightly closed, original container, at room temperature, away from direct sunlight and incompatible substances, keep out of reach of unauthorized personnel, label all containers clearly
Occupational exposure limits: No established OSHA or ACGIH limits; minimize exposure by all reasonable means
Engineering controls: Local exhaust ventilation, process enclosures, or fume hood
Personal protective equipment: Chemical-resistant gloves, lab coat or coverall, safety glasses with side shields or face shield, approved respirator in case of risk of inhalation
Hygiene: Wash hands and face thoroughly after handling, remove contaminated clothes and wash before reuse, do not eat, drink or smoke around the product
Appearance: Pale yellow or light brown crystalline powder
Odor: Slight, characteristic odor
Melting point: 162–163°C
Boiling point: Not determined
Solubility: Slightly soluble in water, soluble in ethanol and chloroform
pH: Not applicable
Vapor pressure: Negligible at room temperature
Density: Approximately 1.21 g/cm³
Flash point: Not applicable
Partition coefficient (log Kow): 0.3 (estimated)
Decomposition temperature: Above 180°C
Other properties: Stable under recommended storage conditions, not volatile
Chemical stability: Stable under standard conditions
Reactivity: Avoid contact with strong oxidizers and acids
Conditions to avoid: Excessive heat, open flames, incompatible materials
Incompatible materials: Strong oxidizing agents, strong acids
Hazardous decomposition products: Nitrogen and sulfur oxides, carbon monoxide, other toxic fumes
Routes of exposure: Inhalation, ingestion, skin and eye contact
Acute toxicity: Oral LD50 (rat) 1,600 mg/kg
Chronic effects: Liver and thyroid toxicity, gastrointestinal upset, possible neurotoxic effects
Symptoms of overexposure: Nausea, vomiting, stomach pain, drowsiness, skin rash or irritation, visual disturbances
Sensitization: May cause allergic reactions by skin contact
Carcinogenicity: Not listed by IARC, NTP or OSHA
Mutagenicity: Evidence for genotoxicity in animal studies
Reproductive effects: Embryotoxic and teratogenic effects observed in animal studies
Ecotoxicity: Toxic to aquatic life, limited data on chronic effects
Persistence and degradability: Not readily biodegradable, likely to persist in the environment
Bioaccumulative potential: Low expected based on molecular structure
Mobility in soil: Moderate mobility, could contaminate groundwater
Other adverse effects: Avoid release to the environment, handle substance with care during use and disposal
Waste disposal: Incinerate waste under controlled conditions according to local, regional and national regulations, do not discharge into sewers or waterways
Unused product: Return to supplier or authorized disposal contractor
Contaminated packaging: Decontaminate and discard as hazardous waste, follow regulatory guidelines
UN number: Not regulated for transport by major agencies
Proper shipping name: Ethionamide
Transport hazard class: Not classified as hazardous for transport
Packing group: Not assigned
Special transport precautions: Use sealed packaging, protect from moisture, keep away from food and animal feed during transit
Regulation status: Prescription-only ingredient in most countries, not listed as a controlled substance
Labelling: Complies with GHS labelling guidelines, includes hazard and precautionary statements
Chemical inventories: Listed on major national inventories (TSCA, EINECS, DSL)
Other applicable regulations: OSHA Hazard Communication Standard, REACH registration where relevant, comply with any local health, safety and environmental regulations
