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Product Name: Erythromycin Thiocyanate
Chemical Family: Macrolide antibiotic
Chemical Formula: C37H67NO13·CNS
CAS Number: 114105-18-5
Synonyms: Erythromycin N-thiocyanate
Molecular Weight: Approx. 822.2 g/mol
Manufacturer Details: Contact details of chemical supplier, emergency contact, and address provided by supplier document
Recommended Use: Antibiotic in research and pharmaceutical manufacturing
Restrictions: Not for direct human therapeutic or veterinary use unless specified
Contact Information: Chemical supplier or emergency response coordination center
Classification: Eye irritation, Skin sensitization, Respiratory system effects
Hazard Symbols: GHS07, Exclamation mark, Health hazard pictogram
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation. May cause allergic skin reaction. Inhalation might result in respiratory tract irritation and difficulty breathing.
Precautionary Statements: Avoid direct contact with skin and eyes. Do not inhale dust or particulate matter. Use only with adequate ventilation.
Potential Health Effects: Irritation of respiratory system, allergic reaction on skin exposure, eye redness and discomfort, gastrointestinal discomfort on accidental ingestion
Emergency Overview: Solid antibiotic powder with low to moderate acute toxicity, but can provoke allergic responses even at small exposures
Chemical Name: Erythromycin Thiocyanate
CAS Number: 114105-18-5
Concentration: >98%% by weight (pharmaceutical grade)
Impurities: Most batches contain trace amounts of erythromycin A and thiocyanate ions. Other unknown impurities below detection threshold.
Other Ingredients: None unless formulated as part of a mixture or pharmaceutical product
EC Number: Not available
Stabilizers/Additives: None
Inhalation: Move individual to fresh air. Provide oxygen or artificial respiration as needed. Medical attention recommended for persistent symptoms.
Skin Contact: Wash area thoroughly using soap and water. Remove contaminated clothing. Medical treatment is required if allergic symptoms or irritation develop.
Eye Contact: Rinse eyes gently but thoroughly with clean water for 15 minutes, occasionally lifting eyelids. Seek immediate medical attention if irritation persists.
Ingestion: Rinse mouth out thoroughly with water. Offer water to drink if consciousness is ensured. Medical evaluation required in all ingestion cases.
Note to Physicians: Treat symptomatically and supportively. Consider monitoring for allergic responses.
Special Medical Attention: Immediate attention is needed if allergic symptoms occur; bring sample of product.
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide.
Unsuitable Extinguishing Media: High-pressure water jets may disperse particles.
Specific Hazards: Organic dusts present potential risk for dust explosions. Toxic thermal decomposition products possible: oxides of carbon, nitrogen, and sulfur.
Special Protective Equipment: Full protective clothing, self-contained breathing apparatus recommended for fire-fighting personnel.
Fire-Fighting Procedures: Isolate site, evacuate unnecessary personnel, avoid producing dust.
Dangerous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, irritating fumes.
Unusual Fire Hazards: Dust accumulation increases risk of flash fire.
Personal Precautions: Evacuate area, keep personnel upwind, avoid breathing dust. Use personal protective equipment such as gloves, goggles, dust masks.
Environmental Precautions: Prevent runoff to drains, surface water, and soil. Prevent spreading by containment and collection.
Cleanup Procedures: Gently sweep up without creating dust. Use damp cloths or HEPA-filter vacuum. Dispose of properly in accordance with local and national regulations.
Decontamination: Wash contact surfaces with detergent and water after clearance.
Disposal: Collected waste needs to be sealed in containers for disposal. Never flush large quantities into sewage or waterways.
Safe Handling: Handle in a well-ventilated space. Avoid generating dust. Do not eat, drink, or smoke during use.
Personal Hygiene: Wash hands and face thoroughly after use.
Storage Conditions: Store tightly sealed in original container, away from direct sunlight, moisture, and sources of ignition. Ambient or cool temperatures improve stability.
Incompatibilities: Avoid strong acids, bases, oxidizing agents.
Storage Class: Pharmaceutical chemical/non-flammable solid
Specific Use Controls: Secure area from unauthorized access, especially children or animals.
Packaging Materials: Polyethylene, polypropylene, or glass
Occupational Exposure Limits: No established ACGIH/TLV or OSHA PEL for erythromycin thiocyanate; maintain exposure as low as reasonably practicable.
Engineering Controls: Local exhaust ventilation, process enclosures, or other controls to keep airborne concentrations below exposure guidelines.
Respiratory Protection: Dust/mist respirator (NIOSH approved type N95 or equivalent) if airborne dust is generated.
Skin Protection: Chemical-resistant gloves (nitrile, latex, neoprene), lab coats or disposable coveralls.
Eye/Face Protection: Safety goggles with side shields or face shields for splash risk.
Workplace Hygiene Measures: Facilities for eye wash and body showers recommended near use areas.
Environmental Exposure Controls: Effective containment to prevent release to environment.
Physical State: Crystalline solid or powder
Color: Off-white to pale yellow
Odor: Faint, medicinal
Odor Threshold: Not determined
pH (1% solution): Slightly acidic to neutral
Melting Point: Decomposes above 165°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not determined
Flammability: Not highly flammable, dust presents risk in some environments
Explosive Properties: Organic dust accumulations may ignite under severe conditions
Solubility (Water): Slightly soluble
Partition Coefficient (log Kow): Data not available
Vapor Pressure: Not significant at room temperature
Relative Density: Approx. 1.25
Viscosity: Not applicable
Auto-ignition Temperature: Not established
Chemical Stability: Stable under normal conditions, degrades over time with intense heat, light, or moisture exposure.
Reactivity: Inert to most typical laboratory chemicals.
Conditions to Avoid: Elevated temperatures, direct sunlight, high humidity, open flames
Materials to Avoid: Strong oxidizing/reducing agents, strong acids, strong bases.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, volatile organic compounds
Polymerization: No hazardous polymerization expected
Acute Toxicity: Low acute oral toxicity; limited human exposure data. Animal LD50 values not well established for this compound.
Skin Irritation: May cause mild to moderate irritation or allergic reaction in sensitive individuals.
Eye Effects: Can cause redness, pain, temporary discomfort.
Respiratory Effects: May cause cough, wheezing, or asthma-like symptoms upon inhalation.
Sensitization: Repeated exposure leads to allergic reactions in sensitized people.
Chronic Exposure: Not sufficiently studied, but macrolides rarely linked with long-term toxicity aside from allergies.
Carcinogenicity: Not listed as carcinogenic by IARC, OSHA, or NTP
Mutagenicity: Limited evidence from laboratory tests; not classified as mutagenic
Reproductive Toxicity: No evidence suggesting reproductive risk identified.
Medical Conditions Aggravated: Asthma, pre-existing allergies, or respiratory diseases.
Ecotoxicity: Data limited; macrolide antibiotics may affect aquatic microorganisms and invertebrates even at low concentrations. Toxic to some aquatic life on prolonged exposure.
Persistence and Degradability: Degrades slowly in aquatic and terrestrial habitats. Persists in sediment.
Bioaccumulative Potential: Potential for bioaccumulation considered low to moderate.
Mobility in Soil: Limited mobility under natural conditions.
Other Harmful Effects: Antibiotic residues may cause development of resistance in aquatic microbiota.
Precautions: Prevent bulk or repeated release to soil, groundwater, or watercourses.
Regeneration Potential: Limited through natural processes in environment.
Disposal Procedures: Material, containers, and contaminated objects must be disposed of in accordance with local, regional, and national regulations.
Incineration: Preferred method of disposal under controlled conditions.
Landfill: Avoid landfill disposal unless allowed by local authority. Prevent contamination of ground and surface waters.
Disposal Containers: Use tightly sealed, labeled hazardous waste containers.
Contaminated Packaging: Destroy, rinse, or otherwise treat as hazardous chemical waste.
UN Number: Not regulated for transportation as dangerous good.
Proper Shipping Name: Erythromycin Thiocyanate
Transport Hazard Class: Not classified
Packing Group: Not assigned
Special Transport Precautions: Avoid release during transit; keep container upright and closed.
Environmental Hazards: Bulk spills during transport must be managed as hazardous waste.
Transport Labels: None specifically required for this substance.
Regulatory Status: Not scheduled under major international conventions, but subject to chemical safety regulations within jurisdictions.
Inventory Listings: Not listed or regulated in the US TSCA, EU EINECS/ELINCS, Australia AICS.
SARA Title III: Not listed under Section 302, 304, or 313.
California Proposition 65: Not listed.
OSHA Requirements: Industrial users must adhere to hazard communication guidelines and chemical hygiene practices.
Other Country-Specific Regulations: May be managed according to specific rules in pharmaceutical or research laboratories.
Risk Phrases: R36/37/38 (Irritating to eyes, respiratory system, and skin)
Safety Phrases: S26, S36/37 (In case of contact with eyes, rinse immediately; wear suitable protective clothing and gloves)
