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Product name: Eperisone Hydrochloride
Chemical name: 1-(4-Ethylphenyl)-2-methyl-3-(1-piperidyl)propan-1-one hydrochloride
CAS number: 73233-44-4
Molecular formula: C17H23NO·HCl
Manufacturer/Supplier: Refer to local distributor or manufacturer contact information
Intended use: Pharmaceutical raw material, muscle relaxant
Synonyms: Myonal, Eperi, Mydocalm Hydrochloride
Emergency contact: Refer to company safety officer or local poison control center
GHS classification: Not classified as hazardous under GHS criteria
Acute toxicity: May cause moderate irritation to eyes and respiratory tract
Routes of exposure: Inhalation, ingestion, skin or eye contact
Health hazards: Prolonged contact could cause skin sensitization or mild respiratory symptoms
Environmental hazards: Expected to pose minimal risk in small pharmaceutical quantities, but avoid uncontrolled environmental release
Signal word: None required by GHS
Pictograms: None required
Precautionary statements: Avoid breathing dust; wash hands thoroughly after handling; wear suitable personal protective equipment as needed
Chemical name: Eperisone Hydrochloride
Common name/synonyms: Eperisone HCl
CAS number: 73233-44-4
Concentration: 98% or greater as supplied
Impurities: Trace manufacturing and process impurities, less than 2% combined
Additives: None for active pharmaceutical ingredient grade, excipients present in formulations only
Inhalation: Move affected individual to fresh air, monitor for respiratory distress, consult medical help if symptoms persist
Eye contact: Rinse eyes gently with plenty of water for at least 10 minutes, seek medical attention if irritation continues
Skin contact: Remove contaminated clothing, wash skin with soap and water, call medical services if rash or discomfort occurs
Ingestion: Rinse mouth thoroughly with water, seek immediate medical attention; do not induce vomiting unless directed by qualified personnel
Symptoms and effects: Irritation to mucous membranes, coughing, dizziness possible after significant exposure
Special advice to physicians: Provide symptomatic and supportive care following accepted medical standards
Suitable extinguishing media: Dry chemical, carbon dioxide, water spray, or foam
Hazardous combustion products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide
Unsuitable extinguishing media: Direct water jet may spread burning dust
Firefighting instructions: Firefighters should wear self-contained breathing apparatus and protective clothing
Risk in case of fire: Toxic and irritating fumes can be released under fire conditions
Protective equipment: Positive pressure breathing apparatus and full protective suit recommended
Additional precautions: Contain runoff to prevent environmental contamination, avoid inhalation of combustion products
Spill procedure: Evacuate area, provide good ventilation, avoid dust formation
Personal precautions: Wear protective gloves, eyewear, and respiratory protection if needed
Containment: Prevent further spill/leakage if safe to do, keep away from drains, soil, and watercourses
Clean-up methods: Collect with inert absorbent (sawdust, terra cotta clay), transfer to closed waste containers, clean area with water after removal
Environmental precautions: Avoid uncontrolled entry to the environment, follow local disposal regulations
Handling precautions: Avoid creating dust, handle in well-ventilated areas, minimize exposure, do not eat, drink, or smoke while handling
Personal protection: Wear gloves, safety goggles, laboratory coat; use local exhaust if dust generated
Storage conditions: Store in a tightly sealed original container, keep in a cool, dry, well-ventilated area away from incompatible substances
Incompatible materials: Strong oxidizing agents, moisture, acids and bases
Special requirements: Store away from food or feedstuffs, keep out of reach of children, clearly label containers
Occupational exposure limits: No established exposure limits; best handled under strict laboratory practices
Engineering controls: Local exhaust ventilation preferred for handling powders
Personal protective equipment (PPE): Chemical-resistant gloves, protective eyewear, laboratory coat, dust respirator for bulk quantities
Hygiene measures: Wash hands after handling; avoid contact with eyes, skin, or clothing
Environmental controls: Prevent spillage into drains or natural water sources
Form: Crystalline powder
Color: White to off-white
Odor: Odorless or faint characteristic
Molecular weight: 293.8 g/mol (free base); 329.85 g/mol (hydrochloride)
Solubility: Freely soluble in water, moderately soluble in methanol, practically insoluble in ether
Melting range: 132-136°C
pH: 4.5 – 6.5 (1% solution in water)
Boiling point: Not applicable (decomposes)
Density: Approximately 1.2 g/cm³
Vapor pressure: Negligible at room temperature
Partition coefficient: LogP 2.2 (estimated)
Other data: Stable under standard temperature and pressure, hygroscopic
Chemical stability: Stable under recommended storage conditions
Conditions to avoid: Exposure to moisture, high temperatures, open flames
Incompatible materials: Strong oxidizing agents, acids, alkalis
Hazardous decomposition products: Hydrogen chloride, oxides of carbon, nitrogen compounds on thermal decomposition
Polymerization: Not anticipated under normal conditions
Reactivity: No significant reactivity expected in pharmaceutical or laboratory settings
Acute toxicity: LD50 (oral, rat): >2000 mg/kg, considered low hazard
Chronic effects: Not fully evaluated for chronic toxicity in humans; long-term exposure could irritate skin or airways
Skin sensitization: Prolonged or repeated exposure may cause dermatitis or mild allergic reaction
Mutagenicity/carcinogenicity: No conclusive data suggest carcinogenic or mutagenic risk from clinical/pharmaceutical uses
Reproductive toxicity: Animal studies show no developmental toxicity at therapeutic doses
Symptoms of exposure: Nausea, drowsiness, mild dizziness, skin rash possible after substantial exposure
Specific organ toxicity: No known specific effects at reasonable levels encountered in manufacturing or preparation
Ecotoxicity: Data limited; low predicted impact at environmentally relevant concentrations
Persistence and degradability: May not be rapidly biodegradable, but low environmental releases from controlled pharmaceutical environments
Bioaccumulative potential: Not expected to bioaccumulate significantly
Mobility in soil: Mobile in water, but absorption to soil expected to be low
Other adverse effects: Use caution to prevent contamination of groundwater and surface water; comply with waste water guidance
Disposal methods: Send to licensed chemical disposal firm; follow all federal, regional, and local environmental regulations
Contaminated packaging: Dispose of as hazardous waste unless thoroughly cleaned
Precautions: Materials should not enter the environment unchecked; neutralize with suitable agents if permitted by local policies
RCRA status (USA): Not listed as hazardous waste, but conservative disposal is strongly advised
UN number: Not regulated for transport as hazardous material
UN proper shipping name: Not classified as dangerous goods
Transport hazard class: Not classified
Packing group: Not assigned
Special precautions: Ship in secure, clearly labeled, tightly sealed containers; protect from moisture and physical damage
Transport regulations: Comply with IATA, IMDG, ADR guidelines for pharmaceuticals where applicable
Inventory status: Listed or exempt from major chemical inventories (TSCA, EINECS/ELINCS, DSL, etc.) for medicinal use
Supervisory standards: No specific national occupational limits; handle according to good industrial hygiene and safety practices
SDS compliance: Meets requirements of US OSHA Hazard Communication Standard, European REACH, and other major regulatory frameworks
Labeling requirements: Provide clear labeling for identity, hazards, and emergency contact
Other regulations: Subject to pharmaceutical registration and controlled substance regulations in some regions; always use according to local pharmaceutical laws
