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Product Name: Diosgenin
Chemical Name: Diosgenin
CAS Number: 512-04-9
Molecular Formula: C27H42O3
Molecular Weight: 414.62 g/mol
Synonyms: 3β-Hydroxy-5-spirostene
Recommended Use: Pharmaceutical intermediate, natural steroid source
Manufacturer: Information available from supplier’s records
Emergency Phone Number: Local medical emergency contacts required
Classification: Eye irritant, skin irritant, may cause respiratory irritation upon prolonged exposure
GHS Label Elements: Warning symbol (exclamation mark), Signal word: Warning
Hazard Statements: Causes mild skin and eye irritation, possible respiratory tract irritation
Precautionary Statements: Wear protective gloves, avoid breathing dust, wash hands thoroughly after handling, use only outdoors or in a well-ventilated area
Potential Health Effects: Irritation to eyes, skin, or respiratory system from dust contact
Chemical: Diosgenin
Concentration: Pure compound (≥99%)
Impurities: Traces of other steroidal saponins possible
Additives: None reported for pure laboratory or industry grade
General Advice: Seek medical attention for all exposures if symptoms persist
Inhalation: Move person to fresh air, provide oxygen if breathing becomes difficult, consult physician
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, seek medical advice if irritation occurs
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, keep rinsing, call for medical help if redness remains
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person, get medical attention if large amounts ingested
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray
Specific Hazards from Fire: May emit toxic fumes of carbon oxides when heated or burned
Protective Equipment: Firefighters need full protective clothing and self-contained breathing apparatus
Advice for Firefighters: Evacuate surroundings, control run-off to prevent environmental contamination
Personal Precautions: Avoid contact with skin and eyes, wear respiratory protection if dust is present, ventilate area
Cleanup Methods: Collect spill with an industrial vacuum or damp cloth, avoid dry sweeping
Environmental Precautions: Keep Diosgenin out of waterways, use barriers to block entry to drains, notify local authorities in case of large spills
Handling: Use only in areas with good ventilation, minimize dust formation, handle with chemically resistant gloves and safety goggles, do not eat or smoke when using this chemical
Storage: Store in a cool, dry, ventilated location, keep container tightly closed, segregate away from incompatible materials such as strong oxidizers, store in labeled, compatible containers
Incompatibilities: Strong oxidizing agents or acids
Exposure Limits: No established occupational exposure limits for Diosgenin
Engineering Controls: Use local exhaust or general dilution ventilation to control airborne dust levels
Personal Protective Equipment: Chemically resistant gloves, long-sleeve clothing, safety goggles, dust mask or particulate respirator when airborne levels may arise
Hygiene Measures: Wash hands after handling, do not bring contaminated PPE home, launder clothing before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless
Melting Point: 204–207 °C
Boiling Point: Not determined
Solubility: Insoluble in water, soluble in alcohol, chloroform, ether
pH: Not applicable
Vapor Density: Not available
Flash Point: Not available
Partition Coefficient (log Kow): 4.6 (estimated)
Auto-Ignition Temperature: Not available
Chemical Stability: Stable under normal conditions of use and storage
Reactivity: Not highly reactive but keep away from oxidists or strong acids
Conditions to Avoid: Excessive heat, open flames, moisture
Hazardous Decomposition Products: Possible formation of carbon oxides during burning
Polymerization: Does not polymerize
Acute Toxicity: Not acutely toxic based on available data, LD50 (oral, rat) reported above 3000 mg/kg
Skin Corrosion/Irritation: May cause mild irritation
Eye Damage/Irritation: Mild irritant in rabbit eye tests
Respiratory or Skin Sensitization: No significant evidence for sensitization
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No data suggestive of reprotoxicity in humans at occupational levels
Target Organ Effects: No specific organ targets identified in the literature
Ecotoxicity: No data available indicating acute environmental hazard, poorly soluble in water so unlikely to mobilize rapidly
Persistence and Degradability: Not readily biodegradable, breakdown expected over prolonged periods in natural environments
Bioaccumulative Potential: Possible bioaccumulation indicated by log Kow value above 4.5
Mobility in Soil: Strong binding to organic matter in soil, limited mobility in aqueous environments
Other Adverse Effects: No known long-term effects at expected use levels
Waste Treatment Methods: Dispose of as chemical waste in accordance with local, regional, national, and international regulations
Disposal of Containers: Rinse containers, puncture and dispose with hazardous chemical waste, prevent product release to environment
Other Advice: Consult local waste authorities for chemical disposal guidance, segregate Diosgenin waste from municipal trash
UN Number: Not classified as a hazardous material for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: None assigned
Packing Group: None assigned
Environmental Hazards: Not considered marine pollutant
Special Precautions: Avoid excessive shaking and keep packaging secure during transport
Federal Regulations: Diosgenin is not listed as a hazardous substance by US OSHA, not subject to SARA Title III section 313 reporting, not on the TSCA list as restricted
International Regulations: Not controlled under EU REACH Annex XVII, not listed by IARC, not recognized as a controlled precursor or chemical
Local Regulations: Site-specific air, water, or chemical storage rules may apply, refer to local governmental publications for details
Other Regulatory Listings: Not included in GHS Annex VI harmonized classification and labeling tables, complies with typical food and pharmaceutical grades for precursor control
