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Product Name: Dihydroxypropyltheophylline
Synonyms: 7-(2,3-dihydroxypropyl) theophylline, Hydrated theophylline propyl derivative
Chemical Formula: C10H14N4O4
CAS Number: 155-10-2
Intended Use: Pharmaceutical intermediate, research chemical, possible bronchodilator
Manufacturer: Contact listed supplier or laboratory where product was sourced
Telephone Number for Emergency: Local poison control, emergency services, or supplier's emergency hotline
GHS Classification: Skin and eye irritant, mild acute toxicity via ingestion, suspected respiratory irritant
Signal Word: Warning
Hazard Statements: Causes skin irritation, causes eye irritation, harmful if swallowed, may cause respiratory irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, wash skin thoroughly after handling, wear protective gloves/eye protection, do not eat/drink while using product
Potential Health Effects: Dermal contact may trigger dermatitis or redness, ingestion can result in nausea, vomiting, abdominal discomfort, inhalation of dust may cause coughing or shortness of breath
Chemical Identity: Dihydroxypropyltheophylline
Concentration: ≥ 98% by weight
Impurities: Water (<1%), theophylline derivative residuals (trace), solvents (<0.1%)
Other Ingredients: No hazardous additives intentionally present
Inhalation: Move individual to fresh air, provide oxygen if breathing becomes difficult, consult physician if symptoms continue
Skin Contact: Rinse thoroughly with soap and water, take off contaminated clothing, consult medical advice if irritation develops or persists
Eye Contact: Rinse with clean water for at least 15 minutes, hold eyelids open, remove contact lenses if present, obtain medical attention
Ingestion: Rinse mouth, do not induce vomiting, contact poison control, seek medical attention if unwell
Emergency Notes: Provide medical personnel with the product label or data sheet, treat symptomatically
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Media: Strong water jets
Special Hazards: Combustion can produce carbon oxides, nitrogen oxides, toxic fumes, and hydrogen cyanide under certain conditions
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Other Advice: Remove containers from fire area if it can be done safely, prevent run-off from entering drain or water bodies
Personal Precautions: Evacuate unnecessary people, ventilate area, use personal protective equipment such as gloves and safety goggles
Environmental Precautions: Prevent spillage from entering drains, sewers, or the environment, notify authorities in case of large spill
Cleanup Methods: Collect spilled powder with inert absorbent, sweep up gently to avoid dust, dispose in accordance with local regulations, wash area with water and detergent
Preventative Measures: Stop leak if safe to do, avoid contact with skin or eyes throughout process
Handling: Wear suitable protective clothing, avoid creating dust, keep container tightly closed, avoid prolonged or repeated exposure
Hygiene Practices: Wash hands thoroughly after handling, avoid eating, drinking, or smoking in areas where material is handled
Storage Conditions: Store in a cool, dry, well-ventilated place, keep away from incompatible substances such as strong acids, strong bases, oxidizing agents
Container Information: Use only original or approved containers, ensure containers are labelled and sealed properly
Exposure Limits: No established TLV or PEL for this compound, general nuisance particulate limits may apply (typically 10 mg/m3 for inhalable dust)
Engineering Controls: Use local exhaust ventilation, work inside a chemical fume hood when dust is generated, minimize exposure through closed systems
Personal Protective Equipment: Safety goggles or face shield, nitrile or neoprene gloves, lab coat, dust mask (N95 or P3 recommended in powder form)
Other Protection: Eye-wash station and safety shower recommended nearby
Appearance: White or off-white crystalline powder
Odor: Odorless or very slight, indistinct chemical scent
Melting Point: 140–148°C
Boiling Point: Decomposes before boiling
pH in Solution: 6.8–7.4 (20°C, water dispersion)
Solubility in Water: Moderately soluble
Relative Density: About 1.44 g/cm3
Vapor Pressure: Not measurable at ambient temperature, negligible
Partition Coefficient (log Kow): Estimated between -1.0 to 0.5
Flash Point: Not applicable
Evaporation Rate: Not applicable
Viscosity: Not applicable in solid state
Chemical Stability: Stable under recommended conditions, may degrade if heated strongly or exposed to light
Reactivity: Not reactive under normal handling and storage
Incompatible Materials: Strong bases, acids, oxidizing agents, reducing agents
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, potentially toxic gases during fire
Polymerization: No known hazardous polymerization
Acute Toxicity: Oral LD50 (rat): Not established, predicted to be > 500 mg/kg
Inhalation: Irritation to upper respiratory tract, coughing or discomfort if dust inhaled
Eye Contact: Irritant, may cause redness, pain, or watering
Skin Contact: Mild irritant, prolonged skin contact can result in redness, itching
Sensitization: No evidence of sensitization in standard tests
Chronic Effects: Repeated exposure may affect kidney or liver function; insufficient long-term data
Carcinogenicity: Not listed in IARC, NTP, OSHA lists
Mutagenicity: No genotoxicity data available
Reproductive Toxicity: No evidence from available studies
Aquatic Toxicity: Data not available, predicted low hazard at standard laboratory concentrations, degradation over time
Persistence and Degradability: Expected to degrade slowly, final products are common organic acids and nitrogenous compounds
Bioaccumulation: Low potential due to water solubility and log Kow
Mobility in Soil: Will dissolve and migrate through soil to water systems, no expected extreme persistence
Other Adverse Effects: No known effects on ozone, greenhouse gases, or photochemical smog
Waste Disposal: Collect residues in clearly labelled chemical waste containers, avoid release to sewage systems, incinerate in accordance with local regulations
Container Disposal: Rinse empty containers three times and dispose as chemical waste, do not reuse containers
Precautions: Avoid unintentional mixing with incompatible materials, always use personal protective equipment during disposal processes
UN Number: Not classified as dangerous goods for transport
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: Not classified as marine pollutant, avoid direct release into environment in case of accidental damage
Special Precautions: Protect packages from physical damage and environmental extremes, conveyance in sealed containers
EU Regulations: Not classified as hazardous substance under current EU directives, not included in REACH candidate list
US Regulations: Not listed in TSCA Inventory, no California Proposition 65 warning required
Other International Regulations: Consult national regulations for pharmaceuticals or laboratory chemicals, may require specific permits for import or use in certain countries
Label Elements: GHS hazard statements and cautionary pictogram required on all containers
