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Product Name: Cinnarizine
Chemical Name: 1-benzhydryl-4-(3-phenylprop-2-enyl)piperazine
CAS Number: 298-57-7
Molecular Formula: C26H28N2
Molecular Weight: 368.5 g/mol
Recommended Use: Antihistamine, treatment of vertigo and motion sickness
Supplier Information: Pharmaceutical supplier or distributor, refer to packaging for specific contacts
Emergency Phone: Refer to local poison control and the packaging label for the most current number
Hazard Classification: Not classified as hazardous according to GHS standards, but can cause irritation to eyes, skin, and respiratory tract
Signal Word: Warning
Potential Health Effects: Swallowing may result in drowsiness, dizziness, dry mouth, gastrointestinal upset, and in severe cases, neurotoxicity; inhalation of dust could cause coughing or respiratory discomfort; prolonged skin contact might lead to irritation; eye exposure may produce redness and discomfort
Label Elements: Avoid inhalation, wear protective gear, wash exposed skin thoroughly after handling
Emergency Overview: Stay away from dust, use adequate ventilation, store safely to avoid accidental exposure
Cinnarizine Content: ≥98% by weight as active pharmaceutical ingredient
Impurities: May contain trace synthetic byproducts and residual solvents, levels within regulatory thresholds for pharmaceutical use
Additives/Excipients: None unless part of a formulated product; check finished product MSDS for additional compounds such as fillers or binders
Other Names: Stugeron, Stunarone
Inhalation: Move to fresh air, ensure breathing is comfortable, seek medical attention if symptoms like dizziness or shortness of breath persist
Skin Contact: Remove contaminated clothing, rinse thoroughly with water and soap, consult a healthcare provider for any persistent irritation
Eye Contact: Rinse immediately with running water for fifteen minutes, avoid rubbing, seek medical examination if discomfort continues
Ingestion: Do not induce vomiting, rinse mouth with water, give water to drink if alert; contact medical help immediately, especially if large quantity ingested or unusual symptoms appear
Notes for Physicians: Symptomatic and supportive treatment, monitor for CNS effects
Suitable Extinguishing Media: Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam
Unsuitable Extinguishing Media: Strong water jet may spread powder
Hazards from Combustion: Thermal decomposition can release toxic fumes of nitrogen oxides and carbon oxides
Advice for Firefighters: Wear full protective equipment with self-contained breathing apparatus, avoid inhalation of fumes
Special Procedures: Remove containers from danger zone if safe, cool containers with water mist, prevent firefighter runoff from entering drains
Personal Precautions: Wear gloves, safety goggles, and dust mask; prevent dust formation in enclosed areas, ventilate spillage zone
Environmental Precautions: Keep spills out of waterways, sewage, and soil
Cleanup Methods: Sweep up spilled material carefully to avoid dust, collect in leak-proof container for disposal, wash spill area with water and detergent
Emergency Procedures: Restrict access to area, notify safety personnel if large spill occurs, handle as per facility protocol
Handling: Use in a well-ventilated location, handle with care to reduce dust dispersion, use personal protective equipment as specified
Avoid: Ingestion, inhalation, and contact with eyes or skin
Storage Conditions: Keep container tightly closed, store in cool, dry, well-ventilated area away from direct sunlight, segregate from incompatible chemicals like strong oxidizers or acids
Safe Packaging: Store in original, intact, clearly labeled containers, avoid reuse of container for other purposes
Storage Temperature: Room temperature (15–25°C) or as specified by manufacturer
Exposure Limits: No established occupational exposure limits; minimize exposure as much as practical
Engineering Controls: Use local exhaust ventilation to reduce airborne dust
Eye Protection: Chemical safety goggles or face shield
Hand Protection: Chemical-resistant gloves (nitrile or latex)
Respiratory Protection: NIOSH-approved dust mask or respirator in dust-generating operations
Other Protection: Lab coat or protective clothing, wash hands before eating, avoid eating or drinking in work area
Appearance: White to off-white crystalline powder
Odor: Odorless or faintly aromatic
pH: 5–7 (in solution)
Melting Point: 119–122°C
Boiling Point: Decomposes before boiling
Density: Approx. 1.2 g/cm³
Solubility: Poorly soluble in water; soluble in alcohol, chloroform, methanol, acetone
Partition Coefficient (log Pow): 5.6 (estimation; high lipid solubility)
Vapor Pressure: Not applicable at room temperature
Evaporation Rate: Non-volatile, not applicable
Flash Point: Not readily flammable
Auto-Ignition Temperature: Not readily auto-igniting
Chemical Stability: Stable under normal conditions and recommended storage
Decomposition Products: On burning or prolonged heating, forms carbon oxides, nitrogen oxides, and other toxic fumes
Incompatible Materials: Strong acids, strong oxidizers, alkali metals
Conditions to Avoid: Exposure to excessive heat, moisture, light, open flame sources
Polymerization: Will not occur under standard handling conditions
Routes of Exposure: Oral, inhalation, skin, eye
Acute Toxicity (LD50): Approx. 420 mg/kg (rat, oral)
Chronic Effects: Long-term or high exposure can affect nervous system, liver, and may impair coordination
Allergic Effects: Rare; skin and respiratory sensitivity cases occasionally reported after excessive exposure
Reproductive Toxicity: Not classed as teratogenic but lacks extensive study in pregnant populations
Carcinogenicity: Not listed as carcinogen by IARC, ACGIH, NTP, OSHA
Symptoms of Exposure: Dizziness, drowsiness, dry mouth, nausea, skin/eye redness
Ecotoxicity: Data limited, but pharmaceuticals in general can affect aquatic organisms at low concentrations, actual risk depends on dilution and persistence
Persistence and Degradability: Slow biodegradation in typical wastewater; may remain in the environment without immediate breakdown
Mobility: Limited solubility in water limits groundwater mobility; high partition coefficient suggests bioaccumulation potential
Bioaccumulation Potential: Moderate to high (log Pow >3)
Other Effects: Avoid discharging large amounts to environment to reduce risk to aquatic life
Disposal Methods: Collect in sealed container and deliver to licensed chemical disposal contractor
Do Not: Dispose via sewage, stormwater, or landfill without special permission from authorities
Contaminated Packaging: Use specialist waste management for disposal; do not recycle packaging for food or drink
Waste Codes: Consult local hazardous waste listings and comply with country-specific regulations
UN Number: Not regulated as hazardous for transport
Proper Shipping Name: Cinnarizine
Transport Hazard Class: Not classified as dangerous goods
Packing Group: Not assigned
Special Precautions: Keep container closed, protect from moisture during transit, transport as per local inventory and handling recommendations
Marine Pollutant: Not classified as marine pollutant, avoid large bulk spillages into environment
GHS Classification: Not hazardous under GHS for normal pharmaceutical use
Labeled Uses: Prescription-only pharmaceutical ingredient in many countries
Inventory Listings: Listed or exempted by major chemical inventories including EINECS and TSCA
OSHA Hazard Communication: Not specifically listed, standard laboratory precautions recommended
Additional Standards: Finished dosage forms must also follow relevant national pharmaceutical regulations; reference country-specific listings for updates
