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Product Name: Cefoperazone Sodium
Synonyms: Cefoperazone sodium salt, Cefobid
Chemical Family: Cephalosporin antibiotic
Recommended Use: Pharmaceutical raw material, antibiotic agent
Manufacturer: [Manufacturer name and contact number]
Emergency Phone: [Emergency contact number]
CAS Number: 62893-20-3
UN Number: Not regulated for transport
Product Code: [Product code is assigned by manufacturer]
GHS Classification: Not classified as hazardous under current regulations, but may cause respiratory or skin sensitization in sensitive individuals
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction, may cause irritation to eyes, skin, and respiratory tract, prolonged exposure can cause adverse effects in those with allergies to beta-lactam antibiotics
Precautionary Statements: Avoid inhalation of dust, avoid skin and eye contact, use personal protective equipment, wash hands thoroughly after handling
Potential Health Effects: Inhalation may cause coughing, sore throat; skin exposure may cause redness or rash; ingestion may upset stomach or cause nausea
Environmental Hazards: Toxic to aquatic life in high concentrations
Cefoperazone Sodium: 98-100% by weight
CAS Number: 62893-20-3
Impurities: Trace levels of related cephalosporin compounds may remain after manufacture, typically below regulatory concern limits
Formulation Additives: None for pure active ingredient; finished pharmaceutical products may include stabilizers, solvents, or excipients depending on manufacturers and formulation requirements
Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash affected area with soap and plenty of water, seek medical advice if irritation develops or rash persists
Eye Contact: Rinse eyes with plenty of water for several minutes, lift eyelids occasionally, seek prompt medical care if irritation continues
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, seek immediate medical attention; inform healthcare provider of material ingested
Special Notes to Healthcare Providers: Treat symptoms, pay special attention to allergies or history of hypersensitivity to beta-lactam antibiotics
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or foam
Unsuitable Extinguishing Media: Strong water jet (may spread powder)
Specific Hazards: May generate toxic fumes such as oxides of nitrogen, sulfur and carbon under fire conditions, powder may create dust explosion hazard if dispersed in air
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing to prevent contact with skin and eyes
Precautions: Remove containers from fire area if safe to do so, cool adjacent areas with water spray, avoid inhaling combustion products
Personal Precautions: Wear suitable protective clothing, gloves, and safety goggles, avoid breathing dust, ensure adequate ventilation
Environmental Precautions: Prevent large quantities from entering drains, surface water or groundwater, notify authorities in case of significant environmental contamination
Cleanup Methods: Collect spilled powder by sweeping or vacuuming with a HEPA filter, place in a sealed container for disposal, wash spill site after removal, avoid creating airborne dust
Safe Handling: Minimize dust generation and accumulation, avoid contact with skin, eyes, and clothing, handle in well-ventilated area, use local exhaust to control airborne dust
Storage Conditions: Store in tightly closed containers, away from direct sunlight, heat sources, oxidizing materials and moisture, recommended storage temperature is between 2°C and 8°C for stability
Incompatibilities: Keep away from acids, alkalis, reducing agents, and strong oxidizing agents
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke in work areas
Occupational Exposure Limits: No specific limits set for Cefoperazone Sodium, general dust exposure levels apply (10 mg/m3 for total dust, 5 mg/m3 for respirable dust as recommended by regulatory bodies)
Engineering Controls: Use fume hood, local exhaust ventilation or process enclosure to avoid airborne exposure
Respiratory Protection: Wear NIOSH-approved particulate respirator in absence of adequate ventilation or during cleanup of spills
Hand Protection: Nitrile or latex gloves that provide chemical resistance
Eye/Face Protection: Chemical safety goggles or face shield during operations likely to produce dust
Skin and Body Protection: Lab coat or disposable coveralls, closed-toe shoes
Environmental Controls: Prevent release to environment using containment and disposal procedures
Appearance: White to off-white crystalline powder
Odor: Odorless
pH (1% solution): 4.0 - 6.5
Boiling Point: Information not established due to decomposition
Melting Point: Decomposes before melting
Solubility: Freely soluble in water
Partition Coefficient (n-octanol/water): Not available
Vapor Pressure: Not applicable (non-volatile solid)
Flash Point: Not applicable
Density: About 1.2 g/cm3
Other Properties: May become light sensitive, maintain in original packaging
Chemical Stability: Stable under recommended storage conditions and handling procedures, decomposes in the presence of strong acids, bases, heat or light
Reactivity: Avoid contact with strong oxidizers and reducing agents, breaks down into biologically inactive compounds under extreme pH or high temperature
Conditions to Avoid: High temperature, moisture, incompatible chemicals, exposure to light
Hazardous Decomposition Products: Produces oxides of carbon, sulfur, nitrogen under decomposition or fire conditions
Polymerization: Not known to undergo hazardous polymerization
Acute Toxicity: LD50 not precisely defined in animal studies, estimated low toxicity by oral and dermal routes for humans due to typical dosage as antibiotic
Potential Health Effects: Can cause hypersensitivity reactions in susceptible individuals, including rash, urticaria, itching or, rarely, anaphylaxis; repeated or prolonged exposure may sensitize some people
Skin and Eye Contact: Irritation, redness, possible allergic reaction
Inhalation: May cause respiratory irritation or allergic symptoms including wheezing
Ingestion: Nausea, vomiting, diarrhea, possible hypersensitivity symptoms
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA or EU
Mutagenicity: No confirmed mutagenic effects in standard tests
Reproductive Toxicity: Not considered a reproductive hazard at therapeutic levels
Medical Conditions Aggravated by Exposure: Individuals with penicillin or cephalosporin allergy, asthma, or chronic skin conditions should avoid exposure
Ecotoxicity: May cause adverse effects to aquatic organisms in high concentrations, potential for bioaccumulation considered low based on water solubility
Mobility in Soil: Freely soluble in water, likely to move through soil to groundwater if released in significant quantities
Persistence and Degradability: Degrades slowly in environment, sunlight and microbial action enhance breakdown, not considered persistent under normal environmental conditions
Bioaccumulative Potential: Low due to rapid breakdown and low partition coefficient
Other Adverse Effects: Use of antibiotics in the environment may contribute to antimicrobial resistance, proper disposal required to prevent contamination
Waste Treatment: Dispose as hazardous pharmaceutical waste according to local, regional, or national regulations; do not discharge to sewer, groundwater or surface waters
Incineration: High-temperature incineration preferred for bulk quantities, maintain compliance with local requirements for emissions and residues
Container Disposal: Triple rinse containers before disposal, follow protocols for pharmaceutical packaging
Special Precautions: Prevent release to the environment, inform disposal personnel of the presence of cephalosporin compound
UN Number: Not classified as hazardous for transportation
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Special Precautions for Transport: Use leak-proof packaging, keep away from moisture and heat during transit, transport under controlled temperature if applicable
Shipping Name: Cefoperazone Sodium
Labeling Requirements: Must display appropriate hazard warnings and identification as a pharmaceutical substance
EU Regulations: Not classified as dangerous under Regulation (EC) No 1272/2008 (CLP)
US Regulations: Not listed on SARA Title III, Section 302 or 313; not on CERCLA hazardous substances list
Controlled Substance: Not a controlled substance under US DEA regulations
OSHA: Not classified as hazardous chemical under Hazard Communication Standard, but good laboratory practices apply
Other National Regulations: Follow national and local pharmaceutical and chemical handling guidelines
International Inventories: Requirements for ingredient declaration and hazard communication may vary by country
