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Product Name: Carvedilol Phosphate
Chemical Formula: C24H26N2O4·H3PO4
Synonyms: Carvedilol Phosphate Salt, (±)-Carvedilol Phosphate
CAS Number: 72956-09-3
Recommended Use: Pharmaceutical ingredient, beta-blocker in antihypertensive therapies
Manufacturer/Supplier: Listed on shipping paperwork, typically found via pharmaceutical vendors
Emergency Contact: Local poison control or emergency response number
Contact Number: Manufacturer’s emergency line printed on outer packaging
Classification: Not classified as hazardous under GHS regulations, though careful handling is required
Hazard Statements: May irritate eyes, skin, and respiratory tract. Risk of harm if ingested in large quantities
Pictograms: None required under typical use, though some global markets may use exclamation mark
Signal Word: Warning
Precautionary Statements: Avoid direct contact; prevent dust build-up; use personal protective gear
Other Hazards: May cause allergic reactions in sensitive individuals; not intended for occupational inhalation or dermal exposure
Chemical Name: Carvedilol Phosphate
Concentration: More than 95% by weight
Impurities: Less than 5%, may include trace solvents or residual reactants
Other Constituents: None regarded as hazardous under typical concentrations
General Advice: Remove contaminated clothing and wash before reuse
Inhalation: Move person to fresh air. Seek medical attention if symptoms such as breathlessness or coughing persist
Skin Contact: Wash thoroughly with soap and plenty of water. Get medical attention if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids. Seek medical help if pain or redness lingers
Ingestion: Rinse mouth with water. Do not induce vomiting unless advised. Contact poison control or a doctor
Most Important Symptoms: Nausea, skin rash, airway irritation, eye redness
Suitable Extinguishing Media: Water spray, dry chemical powder, foam, carbon dioxide
Unsuitable Media: Strong water jets
Special Hazards: May evolve toxic fumes such as carbon oxides, nitrogen oxides, and phosphorous oxides
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Advice for Firefighters: Avoid inhalation of combustion products; control runoff to prevent environmental contamination
Personal Precautions: Use gloves, eye protection, and avoid dust generation
Environmental Precautions: Prevent entry into drains, sewers, waterways by containing spill
Methods for Clean-up: Use damp cloth or absorbent material to collect powder. Place in sealed container for disposal. Ventilate area
Decontamination: Wipe contaminated surfaces thoroughly with water and detergent
Emergency Procedures: Restrict access to spill area until clean-up is complete
Safe Handling: Handle in a well-ventilated area. Use personal protection, avoid all direct contact
Storage Conditions: Store in original tightly closed container, below 30°C, in dry, shaded environment, away from incompatible materials
Incompatibilities: Strong oxidizing agents, strong acids or bases, moisture
Other Recommendations: Keep away from food, beverages, and animal feed
Control Parameters: Occupational exposure limits not established for Carvedilol Phosphate specifically
Engineering Controls: Use local exhaust ventilation, minimize air contamination
Personal Protection: Gloves (nitrile), safety goggles, laboratory coat, dust mask or respirator where exposure exceeds nuisance dust limits
Hygiene Measures: Wash hands after handling; avoid eating or drinking in work area
Appearance: White to off-white crystalline powder
Odor: Odorless or very faint medicinal scent
Melting Point: Range: 114-116°C
Boiling Point: Data not available
Solubility: Freely soluble in water and ethanol; practically insoluble in nonpolar solvents
pH (1% solution): Approximately 3.0-5.0
Vapor Pressure: Negligible at ambient conditions
Partition Coefficient (log P): -0.2 (phosphate salt)
Other Properties: Stable under recommended storage, hygroscopic
Chemical Stability: Stable under dry, cool conditions in sealed container
Reactivity: Will not polymerize
Conditions to Avoid: Exposure to excessive heat, light, and moisture
Incompatible Materials: Strong bases, strong acids, oxidizers
Hazardous Decomposition: Produces carbon oxides, nitrogen oxides, phosphorous oxides if burned
Acute Toxicity: Information on LD50 for Carvedilol Phosphate in animals: oral >2,000 mg/kg (rat)
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: May include headache, dizziness, vomiting, bradycardia, hypotension
Chronic Effects: Not identified for low-level occupational exposure
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No data suggesting reproductive harm in occupational settings
Other Effects: Rare allergic skin reactions reported
Ecotoxicity: Data limited; predicted to be low toxicity to aquatic life at typical residual concentrations
Persistence and Degradability: Slowly biodegradable in water and soil environments
Bioaccumulation Potential: Not expected to bioaccumulate due to physical-chemical properties
Mobility in Soil: Moderate mobility, likely to adsorb to soils and sediments
Other Adverse Effects: Contamination of local waterways should be avoided to protect sensitive species
Waste Treatment Method: Dispose by incineration or via authorized chemical waste contractor
Container Disposal: Triple-rinse and puncture containers before landfilling or recycling
Regulatory Disposal: Follow applicable government, state, and municipal guidelines for pharmaceutical waste
Environmental Precautions: Prevent releases to natural waters and sewage systems
UN Number: Not regulated as hazardous for transportation under ADR, IMDG, IATA
Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified
Packing Group: Not assigned
Marine Pollutant: No
Special Precautions for User: Ensure securely packaged to avoid spillage or inhalation of dust during transit
U.S. Regulatory Status: Listed as prescription pharmaceutical ingredient, subject to FDA and DEA handling rules
TSCA Inventory: Not listed
EU Regulation: Listed in EINECS/ELINCS, regulated as API under EMA guidelines
Other Country Regulations: Check local workplace safety regulations and hazardous substance laws
Label Elements: Comply with GHS labeling, include warning for potential irritation
