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Product Name: Baricitinib
Synonyms: INCB028050; LY3009104
Chemical Formula: C16H17N7O2S
Molecular Weight: 371.42 g/mol
Manufacturer: Contact manufacturer or distributor for details
Intended Use: Pharmaceutical active ingredient (JAK inhibitor)
Contact Information: Refer to supplier documentation
Emergency Phone Number: Obtain from supplier SDS or local poison center
Classification (GHS): Not classified as hazardous under GHS criteria for pharmaceutical products in supplied form
Label Elements: No pictograms designated for this material in finished dosage form
Hazards Not Otherwise Classified: May pose health risks to handling staff; risk increases with large-scale or chronic exposure
Potential Health Effects: Eye, skin, and respiratory tract irritation possible with powder form; harmful if absorbed, swallowed, or inhaled in large quantities
Signal Word: None for finished medicinal product
Chemical Name: 2-[1-ethylsulfonyl-3-(4-pyridin-2-yl-1H-pyrazol-1-yl)azetidin-3-yl]pyrrolo[2,3-d]pyrimidin-4-amine
CAS Number: 1187594-09-7
PURITY: 98% or higher for active ingredient
Impurities: Trace manufacturing residuals — details upon request
Formulation Excipients: Not applicable (pure substance); pharmaceutical tablets/capsules contain additional non-hazardous substances
Inhalation: Move person to fresh air; seek medical attention if symptoms persist; monitor for respiratory distress
Skin Contact: Remove contaminated clothing and rinse skin with soap and water; seek medical advice if irritation or rash develops
Eye Contact: Immediately flush eyes with clean water for several minutes; obtain medical aid if irritation continues
Ingestion: Rinse mouth; do not induce vomiting unless directed by medical personnel; seek medical evaluation, especially if large amounts are involved
Most Important Symptoms: Respiratory and dermal irritation; GI upset if ingested
Notes for Physician: Treat symptomatically; monitor for adverse clinical effects associated with JAK inhibition
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Media: High-pressure water streams may spread powder
Hazardous Combustion Products: Sulfur oxides, nitrogen oxides, carbon oxides
Fire Fighting Instructions: Use protective gear and self-contained breathing apparatus; prevent runoff from entering drains; evacuate area as appropriate
Special Hazards: Product may decompose at high temperatures
Personal Precautions: Use personal protective equipment to prevent skin, eye, and respiratory exposure; avoid dust creation
Environmental Precautions: Prevent release into water courses or drains
Clean-up Methods: Sweep up gently or vacuum with HEPA filtration, place in appropriate sealed container for disposal; wash spill area with water and detergent
Emergency Procedures: Restrict access to spill location; ventilate area
Handling: Employ engineering controls to minimize dust; avoid inhalation and direct contact; wash thoroughly after handling
Storage Conditions: Store at controlled room temperature (15–30°C); keep in original tightly closed container
Incompatibilities: Avoid strong oxidizers; store away from food, beverages, and incompatible substances
Storage Area Requirements: Designated for pharmaceuticals; limit access to trained personnel
Exposure Limits: No occupational exposure limits established; use lowest practicable exposure levels
Engineering Controls: Employ local exhaust ventilation, containment systems, and closed processes when handling bulk material
Personal Protective Equipment: Gloves (nitrile recommended), safety goggles, lab coat, dust mask or respirator for powder
Hygiene Measures: Do not eat, drink, or smoke in handling area; change contaminated clothing immediately
Special Precautions: Use caution with powders and large-scale material transfer
Appearance: White to off-white crystalline powder
Odor: Not significant
Odor Threshold: Not determined
pH: Not applicable (in water, neutral)
Melting Point: ~214–218°C
Boiling Point: Not available
Flash Point: Not determined
Flammability: Not classed as flammable solid
Vapor Pressure: Negligible at room temperature
Solubility: Soluble in DMSO, slightly soluble in water
Partition coefficient (log Kow): ~0.5
Autoignition Temperature: Not established
Decomposition Temperature: >200°C
Evaporation Rate: Not determined
Reactivity: Chemically stable under normal conditions
Chemical Stability: Stable if stored as instructed
Hazardous Reactions: None under recommended use
Conditions to Avoid: High heat, ignition sources, and humidity
Incompatible Materials: Strong oxidizing agents
Hazardous Decomposition Products: Potential release of toxic fumes if heated to decomposition
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Animal studies at high levels have shown GI and hematologic effects
Chronic Toxicity: Long-term exposure may cause immunological, hematological, or hepatic effects
Carcinogenicity: Not classified by IARC/NTP/OSHA
Mutagenicity: Negative in standard tests
Reproductive Toxicity: Data suggest embryo-fetal risk at high dosages
Sensitization: Not expected, but possible with repeated skin contact
Interactive Effects: Additive effects with other JAK inhibitors
Human Health Experience: Adverse effects in clinical trials include infections, thrombosis, changes in blood counts
Ecotoxicity: Information limited; anticipated low to moderate aquatic toxicity based on structure
Persistence and Degradability: Not readily biodegradable; may persist in environment
Bioaccumulative Potential: Low, due to low log Kow
Mobility in Soil: Mobile in aqueous phase; potential for leaching
Other Adverse Effects: Use appropriate procedures to prevent environmental contamination
Product Disposal: Collect waste material in suitable, labelled container; incinerate at approved facility; comply with national and regional regulations
Contaminated Packaging: Dispose as hazardous waste; follow local, state, and federal guidelines
Sewage Disposal: Do not flush to drain or waterway
Disposal Methods: Controlled landfill or incineration preferred for bulk quantities
UN Number: Not regulated under UN Model Regulations for transport
Proper Shipping Name: Not regulated as dangerous good
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Special Precautions for User: Avoid release of dust; keep containers tightly closed during transit
Environmental Hazards: Not an environmentally hazardous substance in transport
Safety, health, and environmental regulations: Complies with FDA, EMA, and other regional pharmaceutical ingredient standards
Inventory Listings: Not listed in TSCA (USA) as pharmaceutical; check national inventories for listing status
Labeling Requirements: Finished products must be labeled per national health authority regulations; bulk substance labeling includes hazard and organization details
REACH Status (Europe): Exempt as medicinal ingredient
WHMIS (Canada): Not controlled as pharmaceutical
OSHA Status (USA): Not hazardous chemical in finished dosage form; bulk material subject to Hazard Communication Standard
