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Product Name: Atomoxetine Hydrochloride
Synonyms: (R)-N-Methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride
CAS Number: 82248-59-7
Molecular Formula: C17H21NO • HCl
Molecular Weight: 291.82 g/mol
Manufacturer: Refer to current supplier documentation
Emergency Contact: Provided by supplier or local poison control
Intended Use: Pharmaceutical intermediate/research chemical
Recommended Restrictions: For laboratory research only, not for drug, household, or other uses
GHS Classification: Acute Toxicity (Oral), Category 4; Eye Irritation, Category 2A; Specific Target Organ Toxicity - Single Exposure, Category 3
Pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes serious eye irritation; May cause respiratory irritation
Precautionary Statements: Avoid breathing dust/fume/gas/mist/vapors; Wash hands thoroughly after handling; Do not eat, drink or smoke while using the product
Potential Health Effects: Inhalation may cause irritation of mucous membranes and upper respiratory tract; Skin contact may cause mild irritation; Eye exposure results in moderate to severe irritation; Ingestion may lead to gastrointestinal disturbances and systemic toxicity
Environmental Hazards: Not classified as hazardous for the environment, potential aquatic toxicity not fully investigated
Substance: Atomoxetine Hydrochloride
Active Ingredient: Atomoxetine Hydrochloride
Purity: Greater than 98% (typical commercial sample)
Impurities/Additives: Trace process solvents and byproducts (less than 2% total); water content usually low
CAS Number: 82248-59-7
EC Number: 279-227-2
Inhalation: Move affected person to fresh air promptly; seek medical attention if symptoms develop or persist; provide support for breathing if effects appear severe
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; consult a doctor if irritation appears
Eye Contact: Rinse cautiously with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally; seek medical evaluation if burning or redness continues
Ingestion: Rinse mouth with water if conscious; do not induce vomiting; seek immediate medical assistance; provide the substance label or MSDS to healthcare professionals
Antidotes/Notes for Doctors: Symptomatic and supportive treatment; observe for delayed respiratory symptoms or neuropathic effects
Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide for small fires; water mist only for large volumes to avoid spreading powders
Fire Hazards: Emits toxic fumes when heated or exposed to flames—hydrogen chloride, nitrogen oxides, and carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear; keep containers cool with water spray if exposed to heat
Special Procedures: Prevent fire-fighting runoff from entering watercourses or drains; avoid stirring powder clouds into flames
Personal Precautions: Wear protective clothing, gloves, eye and respiratory protection; avoid creating and inhaling dust; ventilate the area
Environmental Precautions: Contain spill to prevent entry into drains, water supply, or soil; notify relevant authorities as required by law
Methods for Cleanup: Scoop or vacuum up the solid spill, place in appropriate labelled containers for disposal; wipe up residues using wet absorbent material; clean surfaces with detergent and water
Safe Handling: Avoid all unnecessary exposure; use with adequate ventilation or local exhaust; prevent skin and eye contact; practice good personal hygiene; prohibit eating, drinking, and smoking in handling areas
Storage Conditions: Store in tightly closed original container; keep in a cool, dry, and well-ventilated area, away from incompatible materials such as strong acids and oxidizers; protect from light and moisture
Incompatible Materials: Strong oxidizing agents, acids, and bases may cause decomposition or hazardous reactions
Storage Class: Chemical storage, pharmaceutical/clinical substances
Exposure Limits: No established occupational exposure limits; minimize exposure as much as possible
Engineering Controls: Use local exhaust or general laboratory ventilation to keep airborne levels as low as practical
Protective Equipment: Wear chemical-resistant gloves, lab coat, and safety goggles; use approved respiratory protection if dust forms or if exposure limits could be exceeded
Hygiene Measures: Wash hands after handling and before eating; avoid breathing dust or vapors; promptly remove contaminated clothing and wash before reuse
Appearance: White to off-white crystalline powder
Odor: Odorless or faint amine-like odor
pH (in water): Neutral (5-7 typical for aqueous solutions)
Melting Point: 166°C to 170°C
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water; soluble in methanol, ethanol, slightly soluble in acetone and ether
Flash Point: Not determined for solid form
Vapor Pressure: Not significant at ambient conditions
Relative Density: ~1.2 g/cm³
Partition Coefficient (log Pow): Not available
Decomposition Temperature: Noted above 180°C; releases hazardous vapors
Other Properties: Stable under normal laboratory conditions
Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Exposing to high heat, flames, or strong UV light accelerates decomposition; avoid humid environments
Incompatible Materials: Strong acids, strong alkalis, and oxidizing agents cause hazardous reactions
Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide, nitrogen oxides
Hazardous Reactions: Not prone to violent polymerization or decomposition at room temperature
Acute Toxicity: LD50 (oral, rat) approximately 500 mg/kg
Routes of Exposure: Inhalation, skin, eyes, ingestion
Symptoms of Overexposure: Headache, dizziness, nausea, vomiting, difficulty breathing, central nervous system effects, skin or eye redness
Chronic Effects: Prolonged or repeated exposure may cause liver or kidney effects in experimental animals
Carcinogenicity: No evidence from current available studies
Mutagenicity: Not observed to be mutagenic in standard assays
Reproductive Toxicity: No definitive data in humans; animal data indicate possible developmental toxicity at high doses
Target Organs: Central nervous system, liver
Aquatic Toxicity: Limited data; expected to have low to moderate toxicity to aquatic organisms based on structure
Persistence and Degradability: Not rapidly biodegradable; degrades slowly in soil and water; hydrolysis and photolysis possible
Bioaccumulation Potential: Low, based on predicted log Pow and water solubility
Mobility in Soil: Expected to be moderately mobile, does not strongly bind to soil
Additional Ecological Hazards: Avoid uncontrolled release to the environment; local regulations may require containment or reporting of spills
Product Disposal: Dispose of contents and container in accordance with local, regional, and national regulations; incineration in a chemical waste facility preferred
Contaminated Packaging: Rinse well before disposal or recycle as per chemical waste guidelines
Special Instructions: Do not discharge to surface waters or sewers; consult waste management professionals if bulk disposal is required
UN Number: Not regulated as dangerous for transport under most international guidelines
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Proper Shipping Name: Atomoxetine Hydrochloride or laboratory chemical, solid, n.o.s.
Environmental Hazards: Not considered environmentally hazardous for transport purposes
Transport Precautions: Keep container tightly sealed and protected from moisture; label clearly for shipping; avoid exposure to direct sunlight during transit
EU Regulations: Not listed as a dangerous substance under current regulations; Safety phrases: S22, S24/25
US EPA TSCA Status: Not listed
SARA Title III: Not subject to specific reporting requirements
Canada WHMIS Classification: D2B (Toxic Material Causing Other Toxic Effects)
Other Relevant Laws: Subject to occupational health and chemical safety requirements by OSHA, REACH, CLP; observance of national/local workplace health and safety guidance recommended
Labelling Requirements: Appropriate hazard and precautionary statements, pictograms, emergency contact details
