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Product Name: Antipyrine
Chemical Name: 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one
Synonyms: Phenazone, Analgine
CAS Number: 60-80-0
Recommended Use: Laboratory reagent, pharmaceutical ingredient (under regulated conditions)
Supplier: Refer to manufacturer or distributor details provided on shipment packaging labels
Emergency Contact: Refer to local emergency poison control centers or supplier emergency number
Hazard Classification: Not classified as hazardous under GHS for general laboratory use, but can pose a risk to health upon ingestion, inhalation, or prolonged skin contact
Hazard Statements: May cause irritation to eyes, skin, and respiratory tract; harmful if swallowed
Pictograms: Exclamation mark (Health hazard)
Signal Word: Warning
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, and wear protective gloves/eye protection
Chemical Identity: Antipyrine
Concentration: 100% (for pure substance)
Molecular Formula: C11H12N2O
Molecular Weight: 188.23 g/mol
Impurities: Trace moisture and other pyrazolone derivatives may be present depending on production quality controls
Inhalation: Move to fresh air, seek medical attention if symptoms like coughing or shortness of breath develop
Skin Contact: Remove contaminated clothing, wash exposed area thoroughly with soap and water
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, consult a physician if irritation persists
Ingestion: Rinse mouth, do not induce vomiting, consult a physician or poison center promptly
Acute Symptoms: Headache, dizziness, allergic reactions possible in sensitive individuals
Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam, or water spray
Unsuitable Media: High pressure water streams may spread powder
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, toxic fumes
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear to prevent inhalation of combustion products
Specific Hazards: Dust can form explosive mixtures in air under certain conditions
Personal Precautions: Avoid dust formation, provide adequate ventilation, wear respiratory protection if dust exposure risk exists
Spill Response: Sweep up carefully, minimizing dust, place in suitable, labeled container for disposal
Environmental Precautions: Do not let chemical enter drainage systems or water bodies
Cleaning Methods: Wash spill site after material pickup is complete, use damp cloth or mop for residue
Handling: Use in well-ventilated areas, avoid contact with skin, eyes, and clothing, do not breathe dust
Storage Conditions: Keep container tightly closed, store in a cool, dry, and well-ventilated place, separate from oxidizers and strong acids
Incompatible Materials: Strong oxidizing agents, strong acids
General Hygiene: Wash hands after handling, keep away from food and beverages
Engineering Controls: Use local exhaust or general room ventilation; fume hood preferred for research quantities
Eye Protection: Safety goggles that meet EN166 standards
Skin Protection: Nitrile or neoprene gloves, lab coat, closed-toe shoes
Respiratory Protection: NIOSH/MSHA-approved dust respirator if exposure threshold likely to be exceeded
Environmental Controls: Prevent release to the environment through containment
Appearance: White or slightly yellow crystalline powder
Odor: Odorless
pH: Neutral in water
Boiling Point: Decomposes before boiling
Melting Point: 113–116°C
Solubility: Readily soluble in water, alcohol, ether, and chloroform
Vapor Pressure: Negligible at room temperature
Density: 1.12 g/cm³
Partition Coefficient (log Pow): 0.38 (estimated)
Flash Point: Not highly flammable but dust can be combustible
Auto-ignition Temperature: Data not reliably available
Chemical Stability: Stable under recommended storage conditions
Reactivity: Inert with most materials at ambient temperatures
Hazardous Reactions: May react with strong oxidizing substances, generating heat or gases
Conditions to Avoid: Strong heat, moisture, incompatible substances
Hazardous Decomposition Products: Oxides of carbon and nitrogen upon combustion or thermal decomposition
Potential Health Effects: Irritation to eyes, skin, respiratory tract reported in direct exposure cases
Acute Toxicity: Oral LD50 in rats: 1,020 mg/kg
Chronic Toxicity: Reports of anemia and hematological changes at high or prolonged exposures
Sensitization: Possible allergic reactions with repeated skin contact
Carcinogenicity: No definitive evidence of cancer risk in humans according to major regulatory agencies
Mutagenicity/Teratogenicity: No reports of genetic or reproductive toxicity at standard occupational exposure levels
Ecotoxicity: Not acutely toxic to aquatic life in standard laboratory tests, but can cause oxygen depletion if released in large amounts
Persistence and Degradability: Moderately persistent, may biodegrade over time but remains for weeks in surface waters
Bioaccumulation: Low potential based on molecular structure and water solubility
Mobility in Soil: Soluble, may leach into groundwater if large spills are uncontained
Other Adverse Effects: Avoid release into environment, no evidence of long-term ecosystem disruption with regulated lab-scale use
Waste Disposal: Dispose through permitted chemical waste contractor in accordance with federal, state, and local regulations
Special Precautions: Avoid disposal directly to drains or waterway, all containers and residues require secondary containment in non-leaching vessels
Contaminated Packaging: Treat as chemical waste, triple rinse and manage by professional disposal services if permitted under jurisdiction
UN Number: Not classified as hazardous for transport purposes
Proper Shipping Name: Antipyrine
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Special Transport Precautions: Protect from physical damage, secure container tightly
Environmental Hazards: Not known to pose marine pollution or overland transport risk in properly contained quantities
OSHA: Not hazardous according to OSHA Hazard Communication Standard
TSCA Status: Listed in the U.S. Toxic Substances Control Act inventory
EINECS: Listed under European Inventory of Existing Commercial Chemical Substances, EC No. 200-486-6
SARA Title III: Not subject to SARA Section 313 reporting requirements
Other Regulations: Subject to routine workplace safety controls; medical use falls under FDA or EMA regulations depending on jurisdiction
