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Product Name: Analgin Monohydrate
Chemical Name: 4-(Methylamino)antipyrine monohydrate
CAS Number: 5907-38-0
Synonyms: Metamizole Monohydrate, Dipyrone Monohydrate
Molecular Formula: C13H17N3O4S
Recommended Use: Pharmaceutical intermediate, laboratory reagent
Supplier Details: Available from chemical suppliers, information varies by distributor
Emergency Contact: Reference local supplier information for emergency numbers relevant to the region
Classification: Harmful if swallowed, contact with skin or eyes may cause irritation
GHS Pictogram: Exclamation mark (irritant)
Signal Word: Warning
Hazard Statements: Causes mild to moderate eye and skin irritation; harmful to aquatic life with long-lasting effects; inhalation may cause respiratory tract irritation; may cause adverse effects on blood cells when ingested
Precautionary Statements: Avoid breathing dust; wash hands thoroughly after handling; avoid release to the environment; wear protective gloves, clothing, and eye protection; if in eyes, rinse cautiously for several minutes
Chemical Identity: 4-(Methylamino)antipyrine monohydrate
Content: >98% Analgin Monohydrate
Impurities: Trace amounts of related substances; detailed analysis available per batch
Additives: None indicated
Stabilizers: None stated
Molecular Weight: 311.36 g/mol
General Advice: Move affected person away from exposure area; seek medical attention if symptoms persist
Ingestion: Rinse mouth with water, do not induce vomiting; seek immediate medical help
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing; consult medical personnel for persistent irritation
Eye Contact: Rinse with plenty of water for several minutes; remove contact lenses if present; seek medical attention if redness or pain continues
Inhalation: Move to fresh air immediately; keep at rest in position comfortable for breathing; get medical attention for lingering respiratory symptoms
Extinguishing Media: Use water spray, foam, dry powder, or carbon dioxide; avoid high-pressure water jet
Specific Hazards: May produce toxic fumes of nitrogen, carbon oxides, and sulfur during combustion
Protective Equipment: Firefighters should wear full protective gear, including self-contained breathing apparatus
Special Precautions: Shut off source if safe to do so; prevent run-off from entering drains and watercourses; keep unaffected containers cool with water spray
Personal Precautions: Wear chemical-resistant gloves, safety goggles, lab coat, and NIOSH-approved respirator in dusty conditions
Environmental Precautions: Prevent from entering drains, surface water, or soil
Containment: Sweep up avoiding dust formation and place in a suitable, labeled waste container
Clean-up Methods: Use damp cloth or vacuum with HEPA filter for fine particles; ventilate area thoroughly after cleanup; dispose of in accordance with local regulations
Handling: Avoid contact with skin, eyes, and clothing; do not breathe dust; only handle in well-ventilated areas; do not consume food or drink near work area
Storage: Store in tightly sealed original container; keep in a dry, cool, well-ventilated place away from incompatible substances such as strong oxidizers and acids; protect from moisture, heat, and direct sunlight
Exposure Limits: No established occupational exposure limits; minimize exposure as a general laboratory chemical
Engineering Controls: Use local exhaust ventilation or process enclosure to control airborne dust levels
Personal Protective Equipment: Chemical-resistant gloves; laboratory coat; tightly fitting safety goggles; respiratory protection where ventilation is insufficient or exposure risk exists
Hygiene Measures: Wash hands thoroughly after handling and before eating; remove contaminated clothing immediately
Appearance: White or faintly yellow fine crystalline powder
Odor: Odorless or faint characteristic
Melting Point: 198–200°C
Solubility: Freely soluble in water; slightly soluble in alcohol
pH (1% solution): Approximately 7
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not easily flammable
Vapor Pressure: Negligible at ambient temperature
Density: 1.2–1.4 g/cm³ (approximate)
Partition Coefficient: logP ≈ –0.2 (estimated)
Chemical Stability: Stable under ordinary laboratory conditions and in original packaging
Conditions to Avoid: Avoid elevated temperature, moisture, and direct sunlight
Materials to Avoid: Strong oxidizing agents, strong acids
Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide, methylamine under fire conditions
Polymerization: Not known to occur
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 (rat): 3,150 mg/kg; higher exposures linked to blood dyscrasias
Skin Irritation: Mild; repeated exposure may lead to redness
Eye Irritation: May cause stinging, redness
Sensitization: Skin sensitization reported in rare cases; allergic reactions possible in sensitive individuals
Chronic Effects: Prolonged or repeated exposure may damage blood cells, suppress bone marrow function, or trigger allergic responses
Symptoms: Rash, fever, gastrointestinal upset, sore throat, headache, reduction in white blood cell count possible
Carcinogenicity: No sufficient data to classify; not on IARC, NTP, or OSHA lists
Mutagenicity / Teratogenicity: Data limited; routine precautions advised
Aquatic Toxicity: Toxic to aquatic organisms; causes long-lasting adverse effects in aquatic environments
Persistence and Degradability: Not readily biodegradable; persists in soil and water
Bioaccumulation: Likely low potential for bioaccumulation based on structure and estimated logP
Mobility: Moderately mobile in soil; can enter waterways after spillage
Additional Hazards: Avoid unintentional release to environment to reduce harm to aquatic life
Waste Treatment Methods: Dispose in accordance with local, regional, and national regulations for hazardous chemical waste
Contaminated Packaging: Triple-rinse and dispose of as hazardous waste or incinerate
Special Precautions: Do not discharge into drains or natural waters; use licensed professional waste disposal contractors for larger quantities
Regulatory Compliance: Track and document waste properly to comply with health, safety, and environmental laws
UN Number: Not classified as dangerous for transport under current international regulations
Proper Shipping Name: Not regulated as a hazardous material
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions for Transport: Store upright, sealed, and clearly labeled; protect from moisture and strong impact during shipment; comply with laboratory chemical handling guidelines during internal transport
Label Elements: Required: warning symbol and hazard statement for laboratory and manufacturing use
Risk Phrases: Harmful if swallowed, risk of serious damage to health by prolonged exposure
Safety Phrases: Avoid contact with skin and eyes, keep away from food and drink
Regulatory Status: Not regulated under U.S. TSCA; may be controlled as a pharmaceutical intermediate depending on jurisdiction
Other Applicable Laws: Subject to workplace safety regulations (OSHA, EU REACH, GHS), environmental controls
Restrictions: Use and sale may be restricted in some countries due to pharmaceutical properties
Compliance Measures: Maintain appropriate workplace documentation, training, and labeling as per local and international standards
